Anne Dell (born 11 September 1950) is an Australian
biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...
specialising in the study of
glycomics Glycomics is the comprehensive study of glycomes (the entire complement of sugars, whether free or present in more complex molecules of an organism), including genetic, physiologic, pathologic, and other aspects. Glycomics "is the systematic study o ...
and the
carbohydrate
In organic chemistry, a carbohydrate () is a biomolecule consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with a hydrogen–oxygen atom ratio of 2:1 (as in water) and thus with the empirical formula (where ''m'' may or ma ...
structures that modify
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
s.
Anne's work could be used to figure out how pathogens such as
HIV
The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...
are able to evade termination by the immune system which could be applied toward understanding how this occurs in fetuses. Her research has also led to the development of higher sensitivity
mass spectroscopy
Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is use ...
techniques which have allowed for the better studying of the structure of
carbohydrate
In organic chemistry, a carbohydrate () is a biomolecule consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with a hydrogen–oxygen atom ratio of 2:1 (as in water) and thus with the empirical formula (where ''m'' may or ma ...
s. Anne also established GlycoTRIC at Imperial College London, a research center that allows for glycobiology to be better understood in biomedical applications. She is currently Professor of Carbohydrate Biochemistry and Head of the Department of Life Sciences at
Imperial College London
Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cu ...
.
Dell's other contributions to the study of Glycobiology are the additions she has made to the textbook "Essentials of Glycobiology"
Dell was appointed
Commander of the Order of the British Empire
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations,
and public service outside the civil service. It was established o ...
(CBE) in the 2009 Birthday Honours.
Early life
Anne Dell was the youngest of seven children and grew up on a farm in the
Australian outback
The Outback is a remote, vast, sparsely populated area of Australia. The Outback is more remote than the bush. While often envisaged as being arid, the Outback regions extend from the northern to southern Australian coastlines and encompass a n ...
, where she was educated at home by her mother using Correspondence School lessons until the age of eleven. She earned a First Class Honors degree in
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...
from the
University of Western Australia
The University of Western Australia (UWA) is a public research university in the Australian state of Western Australia. The university's main campus is in Perth, the state capital, with a secondary campus in Albany, Western Australia, Albany an ...
, and came to the UK to carry out her PhD at the
University of Cambridge
, mottoeng = Literal: From here, light and sacred draughts.
Non literal: From this place, we gain enlightenment and precious knowledge.
, established =
, other_name = The Chancellor, Masters and Schola ...
, before joining Imperial College where she is currently employed. She also has a daughter, who was born in 1984.
Education and research
After gaining a First Class Honors degree (equivalent to B.S) in Organic Chemistry from the
University of Western Australia
The University of Western Australia (UWA) is a public research university in the Australian state of Western Australia. The university's main campus is in Perth, the state capital, with a secondary campus in Albany, Western Australia, Albany an ...
, Dell was awarded an 1851 Exhibition Scholarship to study for a PhD at the
University of Cambridge
, mottoeng = Literal: From here, light and sacred draughts.
Non literal: From this place, we gain enlightenment and precious knowledge.
, established =
, other_name = The Chancellor, Masters and Schola ...
.
After she was awarded her PhD in 1975 her doctoral supervisor,
Howard R. Morris, moved to
Imperial College London
Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cu ...
as a lecturer in biochemistry and brought Dell with him.
She would remain at Imperial for the rest of her career.
Anne was elected to the Fellowship of the
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
in 2002 and was appointed a
CBE
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations,
and public service outside the civil service. It was established o ...
in recognition of her services to science in 2009. Other honors include election to Fellowship of the
Academy of Medical Sciences
The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society.
Its mission is to adv ...
and Membership of the European Academy of Science. She has Honorary Doctorates from the
University of Western Australia
The University of Western Australia (UWA) is a public research university in the Australian state of Western Australia. The university's main campus is in Perth, the state capital, with a secondary campus in Albany, Western Australia, Albany an ...
and the
University of Waterloo
The University of Waterloo (UWaterloo, UW, or Waterloo) is a public research university with a main campus in Waterloo, Ontario
Waterloo is a city in the Canadian province of Ontario. It is one of three cities in the Regional Municipality ...
in Canada. In 2017 Dell and her colleagues determined in their experiment that O-linked
glycosylation
Glycosylation is the reaction in which a carbohydrate (or ' glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in order to form a glycoconjugate. In biology (but not al ...
is not necessary for the natural replication cycle of HIV. They also determined that the diversity of the many
GalNAc transferase enzymes that initiate O-linked carbohydrate attachment and the theoretical possibility that natural target cells for HIV ''in vivo'' could potentially complete such O-linked carbohydrate attachment to increase infectivity further.
Dell's other contributions to the study of
Glycobiology
Defined in the narrowest sense, glycobiology is the study of the structure, biosynthesis, and biology of saccharides (sugar chains or glycans) that are widely distributed in nature. Sugars or saccharides are essential components of all living thing ...
are the additions she has made to chapter 50 of the textbook "Essentials of Glycobiology" this chapter gave methods for the characterization of
glycan
The terms glycans and polysaccharides are defined by IUPAC as synonyms meaning "compounds consisting of a large number of monosaccharides linked glycosidically". However, in practice the term glycan may also be used to refer to the carbohydrate p ...
structure, including residue composition, linkage types, and attachment to
aglycone An aglycone (aglycon or genin) is the compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom. For example, the aglycone of a cardiac glycoside would be a steroid molecule.
Detection
A way to identify aglycone ...
s. It covered methods for detection of specific glycan sequences on
glycoprotein
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycos ...
s and it covers methods for characterizing structures in three dimensions. The methods varied widely and included
nuclear magnetic resonance (NMR) spectroscopy
Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique to observe local magnetic fields around atomic nuclei. The sample is placed in a magnetic fie ...
and
mass spectrometry (MS) techniques that allow more detailed structures to be observed in the study of
Glycobiology
Defined in the narrowest sense, glycobiology is the study of the structure, biosynthesis, and biology of saccharides (sugar chains or glycans) that are widely distributed in nature. Sugars or saccharides are essential components of all living thing ...
.
Honors and awards
* Tate and Lyle Medal,
Royal Society of Chemistry
The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Ro ...
(1986)
* Whistler Award, International Carbohydrate Organisation (2000)
*
FRS (2002)
* Haworth Memorial Lectureship,
Royal Society of Chemistry
The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Ro ...
(2003)
* International
Glycoconjugate
Glycoconjugates are the classification family for carbohydrates – referred to as glycans – which are covalently linked with chemical species such as proteins, peptides, lipids, and other compounds. Glycoconjugates are formed in processes ter ...
Organization Award (2005)
*
Fellow of the Academy of Medical Sciences
Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of th ...
(2008)
*
Commander of the Order of the British Empire
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations,
and public service outside the civil service. It was established o ...
(2009)
References
*
Bibliography
*
*
*
*
External links
Dell's profileon the Royal Society website.
{{DEFAULTSORT:Dell, Anne
Female Fellows of the Royal Society
Living people
1950 births
Place of birth missing (living people)
Australian biochemists
Commanders of the Order of the British Empire
British women scientists
Women biochemists
Australian women chemists
Academics of Imperial College London
Fellows of the Royal Society
Fellows of the Academy of Medical Sciences (United Kingdom)