Anirvan Ghosh ( bn, অনির্বাণ ঘোষ) is an American neuroscientist and Biotech executive. He served as the Global Head of Neuroscience Discovery at F. Hoffmann-La Roche from 2011 to 2016 and as founding CSO of E-Scape Bio from 2016 to 2017. He was the Head of Research and Early Development at

Biogen Biogen Inc. is an American multinational biotechnology company based in Cambridge, Massachusetts, specializing in the discovery, development, and delivery of therapies for the treatment of neurological diseases to patients worldwide. History ...

from 2017 to 2020 and is currently the CEO of

Unity Biotechnology Unity Biotechnology is a publicly traded American biotechnology company that develops drugs that target senescent cells. The company's products in development include UBX 1325, which targets Bcl-xL, a mechanism to eliminate senescent cells in a ...

Biography

Anirvan Ghosh was born in 1964 in

Bloomington, Indiana Bloomington is a city in and the county seat of Monroe County in the central region of the U.S. state of Indiana. It is the seventh-largest city in Indiana and the fourth-largest outside the Indianapolis metropolitan area. According to the Mo ...

and grew up in Kanpur, India. After completing high school at Central School (

Kendriya Vidyalaya The Kendriya Vidyalaya Sangathan () is a system of central government schools in India that are instituted under the aegis of the Ministry of Education, Government of India. , it has a total of 1,248 schools in India, and three abroad in Moscow ...

)

IIT Kanpur The Indian Institute of Technology Kanpur (IIT Kanpur) Hindi: भारतीय प्रौद्योगिकी संस्थान कानपुर) is a public institute of technology located in Kanpur, Uttar Pradesh, India. It was ...

, he moved to the U.S. to pursue his undergraduate education at the

California Institute of Technology The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...

. He graduated with a

B.S. A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University ...

with honors in

Physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which r ...

from

Caltech The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...

in 1985. From 1985 to 1990 he was a graduate student in the Stanford University Neurosciences Graduate Program, where he worked on the role of subplate neurons in establishing cortical connections in the laboratory of Carla J. Shatz. He received his

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...

Neurobiology Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developme ...

from Stanford University in 1991. His postdoctoral training was with Michael E. Greenberg at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

where he worked on regulation of differentiation by extracellular signals and calcium regulation of

BDNF Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein found in the and the periphery. that, in humans, is encoded by the ''BDNF'' gene. BDNF is a member of the neurotrophin family of growth factors, which are related to the canon ...

expression. From 1995 to 2003 he was on the faculty in the Department of Neuroscience at the

Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...

. While at Johns Hopkins he cloned CREST as a calcium-regulated transcription factor and showed that it plays a critical role in brain development. In 2003 he moved to

UCSD The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is t ...

as the

Stephen Kuffler Stephen William Kuffler (August 24 Táp, Austria-Hungary, 1913 – October 11, 1980) was a pre-eminent Hungarian-American neurophysiologist. He is often referred to as the "Father of Modern Neuroscience". Kuffler, alongside noted Nobel La ...

Professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professors ...

and served as Chair of Neurobiology in the Division of Biological Sciences. Ghosh served as the Global Head of Neuroscience Discovery at

Roche F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX ...

from 2011 to 2016 and as the Head of Research and Early Development at Biogen from 2017 to 2020. Since 2020 he has served as CEO of UNITY Biotechnology, a company focused on developing therapies to slow, halt, or reverse diseases of aging.

Publications

*Ghosh, A., A. Antonini, S.K. McConnell and C.J. Shatz (1990). Requirement for subplate neurons in the formation of thalamocortical connections. ''Nature'' 347: 179-181 *Ghosh, A. and C.J. Shatz (1992). Involvement of subplate neurons in the formation of ocular dominance columns. ''Science'' 255:1441-1443. *Ghosh, A., J. Carnahan and M.E. Greenberg (1994). Requirement for BDNF in activity-dependent survival of cortical neurons. ''Science'' 263:1618-1623. *Ghosh, A. and M.E. Greenberg (1995). Distinct roles for bFGF and NT3 in the regulation of cortical neurogenesis. ''Neuron'' 15:89-103. *Polleux, F., R.J. Giger, D.D. Ginty, A.L. Kolodkin, and A. Ghosh (1998). Patterning of cortical efferent projections by semaphorin-neuropilin interactions. ''Science'' 282:1904-1906. *Polleux, F., T. Morrow and A. Ghosh (2000). Semaphorin 3A is a chemoattractant for developing cortical dendrites. ''Nature'' 404:567-573. *Aizawa, H., Hu, S-C, Bobb, K., Balakrishnan, K., Ince, G., Gurevich, I., Cowan, M., and A. Ghosh (2004). Dendrite development regulated by CREST, a calcium-regulated transcription activator. ''Science'' 303:197-202. *Qiu, Z. and A. Ghosh (2008) A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. ''Neuron'' 60:775-787. *Sylwestrak, E and A. Ghosh (2012) Elfn1 regulates target-specific release probability at CA1-interneuron synapses. ''Science'' 338:536-540.

References

External links

Official page: Anirvan Ghosh, Professor of Biology, UCSDThe Ghosh Lab
*''

Science Daily ''Science Daily'' is an American website launched in 1995 that aggregates press releases and publishes lightly edited press releases (a practice called churnalism) about science, similar to Phys.org and EurekAlert!. The site was founded by ma ...

''
Gene Essential For Development Of Normal Brain Connections Resulting From Sensory Input Discovered''Science'': Dendrite Development Regulated by CREST, a Calcium-Regulated Transcriptional Activator
* ttps://web.archive.org/web/20080928210513/http://www.elsevier.com/wps/find/bookdescription.cws_home/713893/description#description Fundamental Neuroscience, Elsevierbr>Directory of Pew ScholarsBIOGEN press releaseUNITY BIOTECHNOLOGY press release
{{DEFAULTSORT:Ghosh, Anirvan 1964 births Bengali scientists American people of Bengali descent American neuroscientists People from Kanpur California Institute of Technology alumni Stanford University alumni Harvard Medical School alumni Johns Hopkins University faculty University of California, San Diego faculty Living people Kendriya Vidyalaya alumni Bengali people American academics of Indian descent Scientists from California Indian American American people of Indian descent Indian scholars