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Michael E. Greenberg
Michael Greenberg (born May 25, 1954 in Miami Beach, Florida) is an American neuroscientist who specializes in molecular neurobiology. He served as the Chair of the Department of Neurobiology at Harvard Medical School from 2008 to 2022. Biography Michael Greenberg grew up in Brooklyn, New York and graduated from Wesleyan University (magna cum laude) in 1976 with a degree in chemistry. He conducted his Ph.D. research and began his post-doctoral research at Rockefeller University in New York City in the laboratory of Nobel Laureate Gerald Edelman. He later completed his postdoctoral research with Edward Ziff at New York University Medical Center. During his time in Ziff's lab, Greenberg observed that the transcription of c-fos, a cellular proto-oncogene, is induced within minutes of activation by neurotrophic factors, one of the first mechanistic descriptions of how cells respond to external signals. This finding in cell culture led to the observation that neuronal activity an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miami Beach, FL
Miami Beach is a coastal resort city in Miami-Dade County, Florida. It was incorporated on March 26, 1915. The municipality is located on natural and man-made barrier islands between the Atlantic Ocean and Biscayne Bay, the latter of which separates the Beach from the mainland city of Miami. The neighborhood of South Beach, comprising the southernmost of Miami Beach, along with Downtown Miami and the PortMiami, collectively form the commercial center of South Florida. Miami Beach's population is 82,890 according to the 2020 census. Miami Beach is the 26th largest city in Florida based on official 2019 estimates from the U.S. Census Bureau. It has been one of America's pre-eminent beach resorts since the early 20th century. In 1979, Miami Beach's Art Deco Historic District was listed on the National Register of Historic Places. The Art Deco District is the largest collection of Art Deco architecture in the world and comprises hundreds of hotels, apartments and other structur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston
Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- most populous city in the country. The city boundaries encompass an area of about and a population of 675,647 as of 2020. It is the seat of Suffolk County (although the county government was disbanded on July 1, 1999). The city is the economic and cultural anchor of a substantially larger metropolitan area known as Greater Boston, a metropolitan statistical area (MSA) home to a census-estimated 4.8 million people in 2016 and ranking as the tenth-largest MSA in the country. A broader combined statistical area (CSA), generally corresponding to the commuting area and including Providence, Rhode Island, is home to approximately 8.2 million people, making it the sixth most populous in the United States. Boston is one of the oldest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular & Cellular Neuroscience
''Molecular and Cellular Neuroscience'' publishes original research of high significance covering all aspects of neurosciences indicated by the broadest interpretation of the journal's title. In particular, the journal focuses on synaptic maintenance, de- and re-organization, neuron-glia communication, and de-/regenerative neurobiology. In addition, studies using animal models of disease with translational prospects and experimental approaches with backward validation of disease signatures from human patients are welcome.The Editors are Mathias Bähr (University of Göttingen, Alain Chédotal (Sorbonne University), Henrik Zetterberg (University of Gothenburg and Noam E. Ziv (Technion). References External links * Neuroscience journals Elsevier academic journals Bimonthly journals English-language journals Publications established in 1990 {{neuroscience-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuron (journal)
''Neuron'' is a biweekly peer-reviewed scientific journal published by Cell Press, and imprint of Elsevier. It was established in 1988, and covers neuroscience and related biological processes. The current editor in chief is Mariela Zirlinger. The founding editors were Lily Jan, A. James Hudspeth, Louis Reichardt Louis French Reichardt (born June 4, 1942) is a noted American neuroscientist and mountaineering, mountaineer, the first American to summit both Everest and K2. He was also director of the Simons Foundation Autism Research Initiative, the largest ..., Roger Nicoll, and Zach Hall. A past Editor in Chief was Katja Brose. Transcript and video available. Click on "Transcript" for text. * See alsoA Career in Science Editing: Katja BroseEditor in Chief, Neuron References External links * Neuroscience journals Cell Press academic journals Publications established in 1988 English-language journals Biweekly journals {{neuroscience-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Learning & Memory
''Learning & Memory'' is a monthly peer-reviewed scientific journal covering the neurobiology of learning and memory. It was established in 1994 and is published by Cold Spring Harbor Laboratory Press. The editor-in-chief is John H. Byrne (University of Texas Health Science Center at Houston). Abstracting and indexing The journal is abstracted and indexed in the Science Citation Index, Current Contents/Life Sciences, The Zoological Record, BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of ''Clarivate Analytics Web of Science'' suite. BIOSIS Previews indexes data from 1926 to the present. BIOSIS Previews i ..., PsycINFO, Scopus, and Index Medicus/MEDLINE/PubMed. According to the ''Journal Citation Reports'', the journal has a 2012 impact factor of 4.057. References External links * {{DEFAULTSORT:Learning and Memory Neuroscience journals Monthly journals Cold Spring Harbor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Neuroscience
A journal, from the Old French ''journal'' (meaning "daily"), may refer to: *Bullet journal, a method of personal organization *Diary, a record of what happened over the course of a day or other period *Daybook, also known as a general journal, a daily record of financial transactions *Logbook, a record of events important to the operation of a vehicle, facility, or otherwise *Record (other) *Transaction log, a chronological record of data processing *Travel journal In publishing, ''journal'' can refer to various periodicals or serials: *Academic journal, an academic or scholarly periodical **Scientific journal, an academic journal focusing on science **Medical journal, an academic journal focusing on medicine **Law review, a professional journal focusing on legal interpretation *Magazine, non-academic or scholarly periodicals in general **Trade magazine, a magazine of interest to those of a particular profession or trade **Literary magazine, a magazine devoted to literat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mef2
In the field of molecular biology, myocyte enhancer factor-2 (Mef2) proteins are a family of transcription factors which through control of gene expression are important regulators of cellular differentiation and consequently play a critical role in embryonic development. In adult organisms, Mef2 proteins mediate the stress response in some tissues. Mef2 proteins contain both MADS-box and Mef2 DNA-binding domains. Discovery Mef2 was originally identified as a transcription factor complex through promoter analysis of the muscle creatine kinase (mck) gene to identify nuclear factors interacting with the mck enhancer region during muscle differentiation. Three human mRNA coding sequences designated RSRF (Related to Serum Response Factor) were cloned and shown to dimerize, bind a consensus sequence similar to the one present in the MCK enhancer region, and drive transcription. RSRFs were subsequently demonstrated to encode human genes now named Mef2A, Mef2B and Mef2D. Specie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MECP2
''MECP2'' (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. MECP2 appears to be essential for the normal function of nerve cells. The protein seems to be particularly important for mature nerve cells, where it is present in high levels. The MECP2 protein is likely to be involved in turning off ("repressing" or " silencing") several other genes. This prevents the genes from making proteins when they are not needed. Recent work has shown that MECP2 can also activate other genes. The MECP2 gene is located on the long (q) arm of the X chromosome in band 28 ("Xq28"), from base pair 152,808,110 to base pair 152,878,611. MECP2 is an important reader of DNA methylation. Its methyl-CpG-binding (MBD) domain recognizes and binds 5-mC regions. MECP2 is X-linked and subject to X inactivation. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in fem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autism Spectrum Disorders
The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental disorder, neurodevelopmental condition (or conditions) characterized by difficulties in Social relation, social interaction, verbal and nonverbal communication, and the presence of repetitive behavior and restricted interests. Other common signs include unusual responses to Multisensory integration, sensory stimuli. Autism is generally understood as a ''spectrum disorder'', which means that it can manifest differently in each person: any given autistic individual is likely to show some, but not all, of the characteristics associated with it, and the person may exhibit them to varying degrees. Some autistic people remain nonverbal autism, nonspeaking over the course of their lifespan, while others have relatively unimpaired spoken language. There is large variation in the level of support peop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enhancer RNAs
Enhancer RNAs (eRNAs) represent a class of relatively long non-coding RNA molecules (50-2000 nucleotides) transcribed from the DNA sequence of enhancer regions. They were first detected in 2010 through the use of genome-wide techniques such as RNA-seq and ChIP-seq. eRNAs can be subdivided into two main classes: 1D eRNAs and 2D eRNAs, which differ primarily in terms of their size, polyadenylation state, and transcriptional directionality. The expression of a given eRNA correlates with the activity of its corresponding enhancer in target genes. Increasing evidence suggests that eRNAs actively play a role in transcriptional regulation in cis and in trans, and while their mechanisms of action remain unclear, a few models have been proposed. Discovery Enhancers as sites of extragenic transcription were initially discovered in genome-wide studies that identified enhancers as common regions of RNA polymerase II (RNA pol II) binding and non-coding RNA transcription. The level of RNA po ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NPAS4
Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene. The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior. Function NXF is a member of the basic helix-loop-helix-PER Per is a Latin preposition which means "through" or "for each", as in per capita. Per or PER may also refer to: Places * IOC country code for Peru * Pér, a village in Hungary * Chapman code for Perthshire, historic county in Scotland Math ...- ARNT- SIM (bHLH- PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 ubMed 14701734. upplied by OMIM, Mar 2008 Npas4 has been shown by Dr. Brenda Bloodgood to play critical roles in regulating the plasticity of inhibitory neuro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bdnf
Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein found in the and the periphery. that, in humans, is encoded by the ''BDNF'' gene. BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5. Neurotrophic factors are found in the brain and the periphery. BDNF was first isolated from a pig brain in 1982 by Yves-Alain Barde and Hans Thoenen. BDNF activates the TrkB tyrosine kinase receptor. Function BDNF acts on certain neurons of the central nervous system and the peripheral nervous system expressing TrkB, helping to support survival of existing neurons, and encouraging growth and differentiation of new neurons and synapses. In the brain it is active in the hippocampus, cortex, and basal forebrain—areas vital to learning, memory, and higher thinking. BDNF is also expressed in the retina, kidneys, prostate, motor neurons, and skeletal m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
