Neuronal PAS domain protein 4 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

that in humans is encoded by the NPAS4

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.

Function

NXF is a member of the

basic helix-loop-helix BASIC (Beginners' All-purpose Symbolic Instruction Code) is a family of general-purpose, high-level programming languages designed for ease of use. The original version was created by John G. Kemeny and Thomas E. Kurtz at Dartmouth College ...

PER Per is a Latin preposition which means "through" or "for each", as in per capita. Per or PER may also refer to: Places * IOC country code for Peru * Pér, a village in Hungary * Chapman code for Perthshire, historic county in Scotland Math ...

- ARNT- SIM (bHLH- PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 ubMed 14701734. upplied by OMIM, Mar 2008 Npas4 has been shown by Dr. Brenda Bloodgood to play critical roles in regulating the plasticity of inhibitory neurons. She found that Npas4 helps to regulate plasticity by orchestrating a redistribution of synaptic inputs, biasing them towards dendrites over neuronal cell bodies which increases dendritic plasticity.

Function

References

Further reading