An anaphrodisiac (also antaphrodisiac or antiaphrodisiac) is a substance that quells or blunts the
libido
Libido (; colloquial: sex drive) is a person's overall sexual drive or desire for sexual activity. Libido is influenced by biological, psychological, and social factors. Biologically, the sex hormones and associated neurotransmitters that act u ...
. It is the opposite of an
aphrodisiac
An aphrodisiac is a substance that increases sexual desire, sexual attraction, sexual pleasure, or sexual behavior. Substances range from a variety of plants, spices, foods, and synthetic chemicals. Natural aphrodisiacs like cannabis or cocai ...
, something that enhances sexual appetite. The word ''anaphrodisiac'' comes from the
Greek
Greek may refer to:
Greece
Anything of, from, or related to Greece, a country in Southern Europe:
*Greeks, an ethnic group.
*Greek language, a branch of the Indo-European language family.
**Proto-Greek language, the assumed last common ancestor ...
privative
A privative, named from Latin '' privare'', "to deprive", is a particle that negates or inverts the value of the stem of the word. In Indo-European languages many privatives are prefixes; but they can also be suffixes, or more independent elements. ...
prefix ἀν-, denoting negation, and ''aphrodisiac'', from the Greek goddess of love,
Aphrodite
Aphrodite ( ; grc-gre, Ἀφροδίτη, Aphrodítē; , , ) is an ancient Greek goddess associated with love, lust, beauty, pleasure, passion, and procreation. She was syncretized with the Roman goddess . Aphrodite's major symbols inclu ...
. Some people use anaphrodisiacs in order to curb a very high libido or due to
hypersexuality
Hypersexuality is extremely frequent or suddenly increased libido. It is controversial whether it should be included as a clinical diagnosis used by mental healthcare professionals. Nymphomania and satyriasis were terms previously used for the c ...
. However anaphrodisiacs are also used by those with an average libido, at times due to having incessant schedules.
Available anaphrodisiacs classes of substances
Some common anaphrodisiacs are
ethanol
Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a ...
(alcohol) and
tobacco
Tobacco is the common name of several plants in the genus '' Nicotiana'' of the family Solanaceae, and the general term for any product prepared from the cured leaves of these plants. More than 70 species of tobacco are known, but the ...
, but this is typically an unintended consequence and not often the main reason for use. While alcohol is used socially because it initially reduces mental inhibitions, studies have shown that over time alcohol physically decreases arousal and makes achieving climax more difficult. For this reason alcohol is considered an anaphrodisiac.
Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid use ...
s, a class of pain-reducing substances which include
morphine
Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a pain medication, and is also commonly used recreationally, or to make other illicit opioids. T ...
,
heroin, and
hydrocodone
Hydrocodone, also known as dihydrocodeinone, is an opioid used to treat pain and as a cough suppressant. It is taken by mouth. Typically it is dispensed as the combination acetaminophen/hydrocodone or ibuprofen/hydrocodone for pain severe eno ...
, are anaphrodisiacs.
Side effects
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequence ...
of certain
antidepressant medication
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy ( pharmacotherapy) is an important part of the medical field and ...
s commonly include those taking anaphrodisiac form (there is even a term for the phenomenon among one particularly notorious group—
SSRI
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
SSRIs increase the extracellul ...
-induced
sexual dysfunction
Sexual dysfunction is difficulty experienced by an individual or partners during any stage of normal sexual activity, including physical pleasure, desire, preference, arousal, or orgasm. The World Health Organization defines sexual dysfunction a ...
); however, psychotropic drugs are not currently prescribed for reliable anaphroditic effects.
Antiandrogen
Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. They act by blocking the ...
s such as
cyproterone acetate
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent condition ...
and
medroxyprogesterone acetate are sometimes prescribed to convicted male sex offenders who are released on parole in an effort to stop them reoffending, however the high doses required often cause a range of side effects which may limit
compliance. Other antiandrogens such as
spironolactone
Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood press ...
may also lower sex drive.
Estrogen
Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal ac ...
s can act as anaphrodisiacs in men by suppressing
testosterone
Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristi ...
production by the
testicle
A testicle or testis (plural testes) is the male reproductive gland or gonad in all bilaterians, including humans. It is homologous to the female ovary. The functions of the testes are to produce both sperm and androgens, primarily testoste ...
s. A 2004 study shows Licorice reduces serum testosterone in healthy women (Steroids 69: 763–766
ubMed. A 1999 study shows Licorice also reduces testosterone in healthy men but these results were not confirmed in another study.
History
Herbal anaphrodisiacs have been employed by various religious sects and orders throughout history. Barrister Sir
Edward Marshall Hall
Sir Edward Marshall Hall, (16 September 1858 – 24 February 1927) was an English barrister who had a formidable reputation as an orator. He successfully defended many people accused of notorious murders and became known as "The Great Defende ...
theorised that murderer
Hawley Harvey Crippen
Hawley Harvey Crippen (September 11, 1862 – November 23, 1910), usually known as Dr. Crippen, was an American homeopath, ear and eye specialist and medicine dispenser. He was hanged in Pentonville Prison in London for the murder of his wife Co ...
was using
hyoscine
Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is formally used as a medication for treating motion sickness and postoperative nausea and vomiti ...
on his wife as an anaphrodisiac but accidentally gave her an
overdose
A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended. and then panicked when she died.
Various forms of anaphrodisiacs have been tried to cure
hypersexuality
Hypersexuality is extremely frequent or suddenly increased libido. It is controversial whether it should be included as a clinical diagnosis used by mental healthcare professionals. Nymphomania and satyriasis were terms previously used for the c ...
in both
human
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, cultu ...
s and non-human animals. In both medieval history and modern times, anaphrodisiacs have been used as a tool intended to reduce the sex drive of
sex offender
A sex offender (sexual offender, sex abuser, or sexual abuser) is a person who has committed a sex crime. What constitutes a sex crime differs by culture and legal jurisdiction. The majority of convicted sex offenders have convictions for crim ...
s.
Scientific study
Studies have evaluated the effect of herbal anaphrodisiacs on men and women. These include studies on the effect of substances on both hormone levels and behaviour.
The mechanism of the active component of some plant-based anaphrodisiacs may be the inhibition of enzymes that catalyze the conversion of sex-hormone precursors into
androstenedione, which promotes the reduction of sexual urges. Studies have demonstrated that some of these products inhibit 17β-hydroxysteroid dehydrogenase and 17,20-lyase, which catalyzes the conversion of 17α-hydroxyprogesterone to androstenedione to testosterone.
In one study a group of men were given an anaphrodisiac and the effect on the metabolism of mineralocorticoids in these men was recorded. During the period of administration, the testosterone concentrations decreased and the serum 17α-hydroxyprogesterone concentrations increased. Testosterone levels fell by about 40% after administration and returned to normal after usage was discontinued. However, the actual effect of these medicines on sexual desire was not measured in the study.
The amino acid 5-HTP, or
5-hydroxytryptophan
5-Hydroxytryptophan (5-HTP), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.
Uses
5-HTP is sold over the counte ...
, has been anecdotally reported to be a mild anaphrodisiac, as has the serotonergic empathogen
MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for recreational purposes. The desire ...
, popularly known as "ecstasy". However, systematic study of these chemicals is lacking, due to the off-patent nature of 5-HTP, and the legal control of MDMA. In addition, other serotonergic euphoriant drugs, like the psychedelic
LSD
Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...
, have been reportedly used to drastically increase sexual pleasure. MDMA in combination with a
PDE5 inhibitor
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplyi ...
(trade names
Viagra
Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is unclear if it is effective for treating sexual dysfunction in women. It is taken by ...
,
Levitra, and
Cialis) is termed "sextasy". This combination increases libido and performance simultaneously. A PDE5 inhibitor taken alone has no effect on sex drive, suggesting that serotonergic euphoriants like MDMA may actually increase libido while decreasing performance, similar to
alcohol.
A 2003 study has found that
glycyrrhizin
Glycyrrhizin (or glycyrrhizic acid or glycyrrhizinic acid) is the chief sweet-tasting constituent of ''Glycyrrhiza glabra'' ( liquorice) root. Structurally, it is a saponin used as an emulsifier and gel-forming agent in foodstuffs and cosmet ...
, the compound in
liquorice root, can lower levels of testosterone. The findings back up a previous study about the hormonal effects of liquorice (whose results could not be replicated in other studies in the past). The Iranian scientists came to the conclusion that the regular consumption of liquorice can lower libido in men. However, the study also showed that the level of testosterone normalizes after abstinence of liquorice within a few days and the effects completely disappear.
List of putative anaphrodisiacs
See also
*
Aphrodisiac
An aphrodisiac is a substance that increases sexual desire, sexual attraction, sexual pleasure, or sexual behavior. Substances range from a variety of plants, spices, foods, and synthetic chemicals. Natural aphrodisiacs like cannabis or cocai ...
*
Chemical castration
Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or otherwise. Unlike surgical castration, where the gonads are removed through an incision in the body,
Categories
References
External links
{{Wiktionary, Wikisaurus:anaphrodisiac
''New Scientist'': "The Last Word", 29 June 2002debunks bromide in British Army tea
''Aphrodisiacs and Anti-aphrodisiacs: Three Essays on the Powers of Reproduction'' by John Davenport
Drug classes defined by psychological effects
Sex and drugs
Psychoactive drugs
Anaphrodisia