Allatostatins are

neuropeptide Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...

hormone A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required ...

s in

insect Insects (from Latin ') are pancrustacean hexapod invertebrates of the class Insecta. They are the largest group within the arthropod phylum. Insects have a chitinous exoskeleton, a three-part body ( head, thorax and abdomen), three pairs ...

s and

crustacea Crustaceans (Crustacea, ) form a large, diverse arthropod taxon which includes such animals as decapods, seed shrimp, branchiopods, fish lice, krill, remipedes, isopods, barnacles, copepods, amphipods and mantis shrimp. The crustacean gro ...

. They have a twofold function: they both inhibit the generation of

juvenile hormone Juvenile hormones (JHs) are a group of acyclic sesquiterpenoids that regulate many aspects of insect physiology. The first discovery of a JH was by Vincent Wigglesworth. JHs regulate development, reproduction, diapause, and polyphenisms.The chemic ...

and reduce their food intake. They are therefore putative targets for

insecticide Insecticides are substances used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to b ...

research.{{cite journal , author=Gäde G, Goldsworthy GJ , title=Insect peptide hormones: a selective review of their physiology and potential application for pest control , journal=Pest Manag. Sci. , volume=59 , issue=10 , pages=1063–75 , year=2003 , pmid=14561063 , doi=10.1002/ps.755

Types

Three biochemically distinct types of Allatostatin have been described: A, B and C. Although originally identified in different insects, all three types are found in the fruitfly, ''

Drosophila ''Drosophila'' () is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species ...

''. These types of Allatostatin are not normally found in the same neurons, and so probably have different roles.

Control of food intake

Allatostatin is found in the cells in a small neuronal cluster, the frontal ganglion. It is also present in the axons which leave the frontal ganglion and run across the surface of the gut. Application of low concentrations of Allatostatin inhibit the spontaneous contractions of the gut. All three forms of Allatostatin appear to inhibit gut motility in all the insects which have been tested.

Interaction with juvenile hormone

Juvenile hormone is synthesised in the

corpora allata In insect physiology and anatomy, the corpus allatum (plural: corpora allata) is an endocrine gland that generates juvenile hormone; as such, it plays a crucial role in metamorphosis. Surgical removal of the corpora allata (an allatectomy) can cau ...

. In every insect tested, at least one of the three types of Allatostatin inhibits the biosynthesis of juvenile hormone. This is achieved by

paracrine Paracrine signaling is a form of cell signaling, a type of cellular communication in which a cell produces a signal to induce changes in nearby cells, altering the behaviour of those cells. Signaling molecules known as paracrine factors diffuse ove ...

release of Allatostatin from neurons in the brain which terminate in the corpora allata. The signal is transduced by

GPCR G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...

receptors, but the intracellular pathway is not yet known. Other

amine In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen atoms have been replaced by a substituen ...

and

neurotransmitters may also inhibit juvenile hormone biosynthesis.

References

Peptide hormones Insect hormones