Adrian Clive Hayday (born 1956) FMedSci FRS is the Kay Glendinning professor and Chair in the Department of

Immunobiology Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there ...

at King's College London and group leader at the Francis Crick Institute in the UK.

Education

Hayday was educated at Queens' College, Cambridge, where he was awarded a Bachelor of Arts degree in natural sciences (biochemistry) in 1978. He went on to complete his PhD in

molecular virology Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, thei ...

of ''

Polyomaviridae ''Polyomaviridae'' is a family of viruses whose natural hosts are primarily mammals and birds. As of 2020, there are six recognized genera and 117 species, five of which are unassigned to a genus. 14 species are known to infect humans, while othe ...

'' at

Imperial College London Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cu ...

in 1982.

Career and research

Hayday began studying immunology as a

postdoctoral researcher A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

in 1982 at Massachusetts Institute of Technology (MIT) supervised by Susumu Tonegawa,Adrian Hayday's where he identified the molecular basis of

oncogene An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels.

activation in Burkitt's lymphoma. Thereafter, he first described the genes defining gamma-delta T cells, an evolutionarily conserved yet wholly unanticipated set of

lymphocyte A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. Lymphocytes include natural killer cells (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic ad ...

s. At

Yale University Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United Sta ...

King's College London School of Medicine GKT School of Medical Education (abbreviated: GKT) is the medical school of King's College London. The school has campuses at three institutions, Guy's Hospital (Southwark), King's College Hospital (Denmark Hill) and St Thomas' Hospital (Lambeth ...

and the Francis Crick Institute, Hayday established that gamma-delta T cells are distinct from other

T cell A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell r ...

s, commonly monitoring body-surface integrity rather than specific infections. Their rapid responses to tissue dysregulation offer protection from

carcinogenesis Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abno ...

, underpinning Hayday's and others' ongoing initiatives to employ the cells for

immunotherapy Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as ''activation immunotherapies,'' while immunotherap ...

Awards and honours

Hayday has received numerous awards, including the William Clyde DeVane Medal, Yale's highest honour for scholarship and teaching. He was elected to head the

British Society for Immunology The British Society for Immunology, or BSI, is a UK-based organisation of British immunologists but accepts members from all countries. It was founded in November 1956 by John H. Humphrey, Robin Coombs, Bob White, and Avrion Mitchison and is on ...

(2005–09), and has formally counselled

King's Health Partners King's Health Partners is an academic health science centre located in London, United Kingdom. It comprises King's College London, Guy's and St Thomas' NHS Foundation Trust, King's College Hospital NHS Foundation Trust and South London and Ma ...

, the

Pasteur Institute The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines ...

, Kyoto University, the

Max Planck Institute Max or MAX may refer to: Animals * Max (dog) (1983–2013), at one time purported to be the world's oldest living dog * Max (English Springer Spaniel), the first pet dog to win the PDSA Order of Merit (animal equivalent of OBE) * Max (gorilla) ...

, the Allen Institute,

MedImmune MedImmune, LLC was a wholly owned subsidiary of AstraZeneca before February 14, 2019, when it was announced that the MedImmune name and branding would be discontinued in favor of AstraZeneca. MedImmune was founded in 1988 as Molecular Vaccines, ...

, the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

, the

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...

, and

Cancer Research UK Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and t ...

whose science committee he chairs. He was elected a Fellow of the Royal Society (FRS) in 2016. One or more of the preceding sentences incorporates text from the royalsociety.org website where: He is an honorary member of the

References

Living people Alumni of Queens' College, Cambridge Alumni of Imperial College London Academics of King's College London Fellows of the Academy of Medical Sciences (United Kingdom) Fellows of the Royal Society British immunologists 1956 births Academics of the Francis Crick Institute Fellows of King's College London {{UK-scientist-stub