An Activin receptor is a receptor which binds
activin.
Types include:
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Activin type 1 receptors
*
Activin type 2 receptors
The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved in a host of physiological processes including, growth, cell differentiation, ...
These proteins are
receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain.
Human proteins containing this domain
ACVR1
Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ''ACVR1'' gene; also known as ALK-2 (activin receptor-like kinase-2). ACVR1 has been linked to the 2q23-24 region of the genome. This protein is important in the bo ...
;
ACVR1B
Activin receptor type-1B is a protein that in humans is encoded by the ''ACVR1B'' gene.
ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a c ...
;
ACVR1C
The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB family of signaling molecules.
ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and ...
;
ACVR2A
Activin receptor type-2A is a protein that in humans is encoded by the ''ACVR2A'' gene.
ACVR2A is an activin type 2 receptor.
Function
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which ...
;
ACVR2B
Activin receptor type-2B is a protein that in humans is encoded by the ''ACVR2B'' gene. ACVR2B is an activin type 2 receptor.
Function
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-bet ...
;
ACVRL1
Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ''ACVRL1'' gene.
ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as activin receptor-like kinase 1, or ALK1.
Function
This gene ...
;
BMPR1A
The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the ''BMPR1A'' gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292).
Function
The bone morphogenetic pr ...
;
BMPR1B;
BMPR2;
TGFBR1
Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family for the TGF beta superfamily of signaling ligands. ''TGFBR1'' is its human ...
;
References
External links
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GS domain
TS domain
S/T domain
Single-pass transmembrane proteins
{{transmembranereceptor-stub