ADX-71441 is a GABA_B receptor positive allosteric modulator currently being investigated as a potential treatment for anxiety, epilepsy, pain and other conditions.

Therapeutic potential

Addiction

ADX-71441 has been shown to reduce alcohol consumption. This result was observed in both alcohol dependent and non-dependent animals. There were also trials about

nicotine addiction Nicotine is a natural product, naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and ''Duboisia hopwoodii'') and is widely used recreational drug use, recreationally as a stimulant and anxiolytic. As ...

, which showed positive results: ADX-71441 was able to decrease some withdrawal symptoms of nicotine withdrawal.

Anxiety

This compound has also been shown to reduce anxiety in people with PTSD.

Pain

Experiments have shown that this compound was able to decrease hypersensitivity to pain in mice, Guinea pigs and rats.

Tolerance

ADX-71441 has been shown to have less tolerance and side effects than direct GABA_B agonists, such as baclofen.

References

{{GABA receptor modulators GABA receptor ligands Fluoroarenes Acetamides Methoxy compounds Triazines Chloroarenes Ureas