7,''N'',''N''-trimethyltryptamine (7-methyl-DMT, 7-TMT), is a
tryptamine derivative which acts as an
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
of
5-HT2 receptors.
In animal tests, both 7-TMT and its 5-methoxy derivative
5-MeO-7-TMT produced behavioural responses similar to those of
psychedelic
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...
drugs such as
DMT
''N'',''N''-Dimethyltryptamine (DMT or ''N'',''N''-DMT, SPL026) is a substituted tryptamine that occurs in many plants and animals, including human beings, and which is both a derivative and a structural analog of tryptamine. It is used as a ...
, but the larger 7-ethyl and 7-bromo derivatives of DMT did not produce psychedelic responses despite having higher 5-HT
2 receptor affinity ''in vitro'' (cf.
DOBU,
DOAM).
7-TMT also weakly inhibits
reuptake of serotonin but with little effect on dopamine or noradrenaline reuptake.
See also
*
2,N,N-TMT
2,''N,N''-trimethyltryptamine, 2,''N,N''-TMT, or 2-Me-DMT is a tryptamine derivative that is a psychedelic drug. It was invented by Alexander Shulgin and reported in his book TiHKAL (#34). It is claimed to show psychoactive effects at a dosage of ...
*
5,N,N-TMT
5,''N'',''N''-trimethyltryptamine (5,''N'',''N''-TMT; 5-TMT) is a tryptamine derivative that is a psychedelic drug. It was first made in 1958 by E. H. Young. In animal experiments it was found to be in between DMT and 5-MeO-DMT in potency which ...
*
7-Methyl-αET
*
7-Chloro-AMT
7-Chloro-α-methyltryptamine (7-Cl-AMT) is a tryptamine derivative with stimulant effects, invented in the 1960s. It is a weak monoamine oxidase inhibitor but its pharmacology has not otherwise been studied by modern techniques, though several c ...
References
Serotonin receptor agonists
Tryptamines
Dimethylamino compounds
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