5-Fluoro-DET (5F-DET, 5-fluoro-''N,N''-diethyltryptamine) is a
tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...
derivative related to drugs such as
DET and
5-MeO-DET
5-MeO-DET or 5-methoxy-''N,N''-diethyltryptamine is a hallucinogenic tryptamine.
Pharmacology
5-MeO-DET inhibits serotonin reuptake with an IC50 value of 2.4 μM and activates 5-HT2A receptors with an EC50 value of 8.11 nM.
Effects
Low dosages ...
.
It acts as an inhibitor of the enzyme
myeloperoxidase
Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the ''MPO'' gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry ou ...
,
and is also thought to be an
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
at the
5-HT2A receptor.
See also
*
5F-DMT
5-Fluoro-''N'',''N''-dimethyltryptamine (5-fluoro-DMT, 5F-DMT) is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT. Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT2A/C receptor af ...
*
5F-MET
5-Fluoro-MET (5F-MET, 5-fluoro-''N''-methyl-''N''-ethyltryptamine) is a psychedelic tryptamine derivative related to drugs such as 5-Fluoro-DMT and N-Methyl-N-ethyltryptamine (MET). It acts as an agonist at the 5-HT2A receptor with an EC50 of 2 ...
*
5F-EPT
5-Fluoro-EPT (5F-EPT, 5-fluoro-''N''-ethyl-''N''-propyltryptamine) is a psychedelic tryptamine derivative related to drugs such as EPT and 5-MeO-EPT. It acts as a potent full agonist at the 5-HT2A receptor with an EC50 of 5.54 nM and an effi ...
*
6F-DET
References
Psychedelic tryptamines
Tryptamines
Fluoroarenes
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