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5-Fluoro-MET (5F-MET, 5-fluoro-''N''-methyl-''N''-ethyltryptamine) is a
psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...
tryptamine derivative related to drugs such as
5-Fluoro-DMT 5-Fluoro-''N'',''N''-dimethyltryptamine (5-fluoro-DMT, 5F-DMT) is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT. Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT2A/C receptor a ...
and
N-Methyl-N-ethyltryptamine ''N''-Methyl-''N''-ethyltryptamine (MET) is a psychedelic tryptamine. It is closely related to DMT and DET. There is very little information on the human pharmacology or toxicity Toxicity is the degree to which a chemical substance ...
(MET). It acts as an
agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
at the 5-HT2A receptor with an EC50 of 20.6 nM and produces a head-twitch response in animal studies. Ring fluorination in this case increases efficacy at 5-HT2A, with 5F-MET having an efficacy of 87.6% vs
5-HT Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...
, vs 36.2% for the partial agonist MET. It is claimed to have
antidepressant Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness, hea ...
activity.


See also

* 5-Fluoro-AMT * 5-Fluoro-AET *
5-Fluoro-DET 5-Fluoro-DET (5F-DET, 5-fluoro-''N,N''-diethyltryptamine) is a tryptamine derivative related to drugs such as DET and 5-MeO-DET. It acts as an inhibitor of the enzyme myeloperoxidase, and is also thought to be an agonist An agonist is a chem ...
* 5-Fluoro-EPT * 5-MeO-MET


References

Psychedelic tryptamines Tryptamines Fluoroarenes {{pharm-stub