5-Ethoxy-DMT (5-ethoxy-''N'',''N''-dimethyltryptamine, 5-EtO-DMT, ''O''-ethylbufotenine) is a

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...

derivative In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. F ...

which has been previously synthesized as a chemical intermediate, but has not been studied to determine its pharmacology. The widespread recreational use of ''N'',''N''-dialkylated

5-methoxytryptamine 5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynthesized via the deacet ...

derivatives including

5-MeO-DMT 5-MeO-DMT (5-methoxy-''N'',''N''-dimethyltryptamine) or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Colorado Ri ...

5-MeO-MiPT 5-MeO-MiPT is a psychedelic and hallucinogenic drug, used by some as an entheogen. It has structural and pharmacodynamic properties similar to the drugs 5-MeO-DiPT, DiPT, and MiPT. It is commonly used as a "substitute" for 5-MeO-DiPT because o ...

and

5-MeO-DiPT 5-Methoxy-''N'',''N''-diisopropyltryptamine (5-MeO-DiPT, sometimes called Foxy Methoxy or simply Foxy) is a psychedelic tryptamine and the methoxy derivative of diisopropyltryptamine (DiPT). Pharmacology The mechanism that produces the purport ...

has led to concern that the 5-ethoxy

homologs A couple of homologous chromosomes, or homologs, are a set of one maternal and one paternal chromosome that pair up with each other inside a cell during fertilization. Homologs have the same genes in the same locus (genetics), loci where they pr ...

of these drugs could emerge as novel designer drugs, and consequently 5-EtO-DMT and other derivatives including 5-EtO-DET, 5-EtO-DPT, 5-EtO-DiPT, 5-EtO-DALT, 5-EtO-MPT, 5-EtO-MiPT, 5-EtO-EiPT, 5-EtO-MET and 5-EtO-EPT have been synthesized as analytical standards in order to facilitate future research into these compounds.

References

Tryptamines Dimethylamino compounds {{pharmacology-stub

See also

References