4F-MDMB-BINACA (also known as 4F-MDMB-BUTINACA or 4F-ADB) is an
indazole-based synthetic
cannabinoid from the indazole-3-carboxamide family. It has been used as an active ingredient in
synthetic cannabis
Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be confused with synthetic ...
products and sold as a
designer drug since late 2018. 4F-MDMB-BINACA is an
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
of the
CB1 receptor (EC
50 = 7.39 nM),
though it is unclear whether it is selective for this target. In December 2019, the
UNODC announced scheduling recommendations placing 4F-MDMB-BINACA into Schedule II throughout the world.
Related compounds
The corresponding indole core analogue,
4F-MDMB-BICA
-MDMB-BINACA (also known as 4F-MDMB-BUTINACA or 4F-ADB) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family. It has been used as an active ingredient in synthetic cannabis products and sold as a designer drug since ...
or 4F-MDMB-BUTICA has also been widely sold as a designer drug by chemical providers on the net, first being identified in May 2020.
Analytical data for 4F-MDMB-BICA. Hungarian Institute for Forensic Sciences. 28-05-2020
/ref>
Legal Status
United Kingdom
It's illegal to sell, distribute, supply, transport or trade the pharmaceutical drug under the Psychoactive Substances Act 2016.
See also
*5F-MDMB-PINACA
5F-ADB (also known as 5F-MDMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug. 5F-A ...
*5F-MDMB-PICA
5F-MDMB-PICA is a designer drug and synthetic cannabinoid. In 2018, it was the fifth-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Administration.
5F-MDMB-PICA is a potent agonist of both the CB1 recept ...
*5F-MMB-PINACA
5F-AMB (also known as 5F-MMB-PINACA and 5F-AMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products. It was first identified in Japa ...
* 5F-MPP-PICA
*AB-FUBINACA
AB-FUBINACA is a drug that acts as a potent agonist for the cannabinoid receptors, with ''K''i values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2. It was originally developed by P ...
References
Cannabinoids
Designer drugs
Organofluorides
Indazolecarboxamides
Tert-butyl compounds
{{cannabinoid-stub