3',4'-Methylenedioxy-α-pyrrolidinobutyrophenone (MDPBP) is a
stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...
of the
cathinone
Cathinone (; also known as β-ketoamphetamine) is a monoamine alkaloid found in the shrub ''Catha edulis'' (khat) and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines. It is probably the main contributor to t ...
class developed in the 1960s, which has been reported as a novel
designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. ...
. MDPBP is sometimes sold under the name "NRG-1" as a mixture with other cathinone derivatives, including
flephedrone,
pentylone
Pentylone is a stimulant developed in the 1960s. It is a substituted cathinone that has been identified in some samples of powders sold as "NRG-1", along with varying blends of other cathinone derivatives including flephedrone, MDPBP, MDPV, a ...
,
MαPPP and its higher homologue
MDPV
Methylenedioxypyrovalerone (abbreviated MDPV, and also called monkey dust) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ing ...
. As with other
cathinones
Substituted cathinones, or simply cathinones, which include some stimulants and Empathogen-entactogen, entactogens, are chemical derivative, derivatives of cathinone. They feature a substituted phenethylamine, phenethylamine core with an alkyl ...
, MDPBP has been shown to have reinforcing effects in rats.
The main metabolic steps are thought to be demethylenation followed by methylation of one hydroxy group, aromatic and side chain hydroxylation, oxidation of the pyrrolidine ring to the corresponding lactam as well as ring opening to the corresponding carboxylic acid. CYP2C19 and CYP2D6 have been identified as the isoenzymes mainly responsible for demethylenation.
Legal Status
MDPBP is a controlled substance in Poland and China.
See also
*
α-Pyrrolidinobutiophenone (α-PBP)
*
Butylone
Butylone, also known as β-keto-''N''-methylbenzodioxolylbutanamine (βk-MBDB), is a psychoactive drug of the substituted phenethylamine, phenethylamine, substituted amphetamine, amphetamine, phenylisobutylamine, and substituted cathinone, cathin ...
*
3',4'-Methylenedioxy-α-pyrrolidinopropiophenone
3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) is a stimulant designer drug. It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills. It shares a similar chemical structure with α-P ...
(MDPPP)
*
Methylenedioxypyrovalerone
Methylenedioxypyrovalerone (abbreviated MDPV, and also called monkey dust) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer In ...
(MDPV)
References
Designer drugs
Methylenedioxyphenethylamines
Phenylisobutylamines
Pyrrolidinophenones
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