Aminomethyl propanol is an
organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. Th ...
with the formula H
2NC(CH
3)
2CH
2OH. It is colorless liquid that is classified as an
alkanolamine. It is a useful buffer and a precursor to numerous other organic compounds.
Synthesis
Aminomethyl propanol can be produced by the
hydrogenation
Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to reduce or saturate organic ...
of
2-aminoisobutyric acid or its esters.
Properties
Aminomethyl propanol is soluble in water
and about the same density as water.
Uses
Aminomethyl propanol is used for the preparation of
buffer solution
A buffer solution (more precisely, pH buffer or hydrogen ion buffer) is an aqueous solution consisting of a mixture of a weak acid and its conjugate base, or vice versa. Its pH changes very little when a small amount of strong acid or base is ...
s.
It is a component of the drugs
ambuphylline and
pamabrom. It is also used in
cosmetics
Cosmetics are constituted mixtures of chemical compounds derived from either natural sources, or synthetically created ones. Cosmetics have various purposes. Those designed for personal care and skin care can be used to cleanse or protec ...
.
It is a precursor to
oxazoline
Oxazoline is a five-membered heterocyclic organic compound with the formula . It is the parent of a family of compounds called oxazolines (emphasis on plural), which contain non-hydrogenic substituents on carbon and/or nitrogen. Oxazolines are th ...
s via its reaction with
acyl chloride
In organic chemistry, an acyl chloride (or acid chloride) is an organic compound with the functional group . Their formula is usually written , where R is a side chain. They are reactive derivatives of carboxylic acids (). A specific example o ...
s. Via sulfation of the alcohol, the compound is also a precursor to 2,2-dimethylaziridine.
It is used in the synthesis of
Fepradinol &
G-130. It is also used for
Isobucaine, and
Radafaxine
Radafaxine (developmental code name GW-353,162), also known as (2''S'',3''S'')-hydroxybupropion or (''S'',''S'')-hydroxybupropion, is a norepinephrine–dopamine reuptake inhibitor (NDRI) which was under development by GlaxoSmithKline in the 200 ...
.
References
{{Reflist
Amines
Primary alcohols