10-Deacetylbaccatins are a series of closely related natural

organic compound In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The ...

s isolated from the yew tree (Genera ''

Taxus ''Taxus'' is a genus of coniferous trees or shrubs known as yews in the family Taxaceae. They are relatively slow-growing and can be very long-lived, and reach heights of , with trunk girth averaging . They have reddish bark, lanceolate, flat, ...

''). 10-Deacetylbaccatin III is a precursor to the anti-cancer drug

docetaxel Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-ce ...

(Taxotere). 10-deacetylbaccatin III 10-''O''-acetyltransferase converts 10-deacetylbaccatin to

baccatin III Baccatin III is an isolate from the yew tree (Genera ''Taxus''). Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol). In 2014, researchers reported introduction and expression of the endophytic fungal gene responsible for synt ...

: :acetyl-CoA + 10-deacetylbaccatin III CoA + baccatin III

External links

* - 7-Epi-10-Deacetylbaccatin III * - 10-Deacetylbaccatin V * - 10-Deacetylbaccatin VI * - 13-Epi-10-Deacetylbaccatin III * - 13- -(2-Naphthyl)prop-2-enoyl2-debenzoyl-2-(4-methoxybenzoxyl)-10-deacetylbaccatin III * - 10-''N'',''N''-Dimethylglycyl-13- -(2-Naphthyl)prop-2-enoyl10-deacetylbaccatin III Benzoate esters Secondary alcohols Tertiary alcohols Ketones Diterpenes Acetate esters {{ketone-stub