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Baccatin III
Baccatin III is an isolate from the yew tree (Genera ''Taxus''). Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol). In 2014, researchers reported introduction and expression of the endophytic fungal gene responsible for synthesizing baccatin III (10-deacetylbaccatin III 10-O-acetyltransferase), to the mushroom ''Flammulina velutipes''. Researchers achieved the same accomplishment with'' Escherichia coli'' in 2000. See also * 10-Deacetylbaccatin * Taxadiene Taxadiene (taxa-4,11-diene) is a diterpene. Taxadiene is the first committed intermediate in the synthesis of taxol. Six hydroxylation reactions, and a few others, are needed to convert taxadiene to baccatin III. Enzymatically, taxadiene is prod ... References Taxanes Benzoate esters Acetate esters {{ester-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxus
''Taxus'' is a genus of coniferous trees or shrubs known as yews in the family Taxaceae. They are relatively slow-growing and can be very long-lived, and reach heights of , with trunk girth averaging . They have reddish bark, lanceolate, flat, dark-green leaves long and broad, arranged spirally on the stem, but with the leaf bases twisted to align the leaves in two flat rows either side of the stem. The oldest known fossil species are from the Early Cretaceous. Morphology The seed cones are highly modified, each cone containing a single seed long partly surrounded by a modified scale which develops into a soft, bright red berry-like structure called an aril, long and wide and open at the end. The arils are mature 6–9 months after pollination, and with the seed contained are eaten by thrushes, waxwings and other birds, which disperse the hard seeds undamaged in their droppings; maturation of the arils is spread over 2–3 months, increasing the chances of successful seed d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paclitaxel
Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer. This includes ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by intravenous injection. There is also an albumin-bound formulation. Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea. Other serious side effects include heart problems, increased risk of infection, and lung inflammation. There are concerns that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function of microtubules during cell division. Paclitaxel was first isolated in 1971 from the Pacific yew and approved for medical use in 1993. It is on the World Health Organization's List of Essential Medicines. It has been made from precu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
10-deacetylbaccatin III 10-O-acetyltransferase
In enzymology, a 10-deacetylbaccatin III 10-O-acetyltransferase () is an enzyme that catalyzes the chemical reaction :acetyl-CoA + 10-deacetylbaccatin III \rightleftharpoons CoA + baccatin III Thus, the two substrates of this enzyme are acetyl-CoA and 10-deacetylbaccatin III, whereas its two products are CoA and baccatin III. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is acetyl-CoA:taxan-10beta-ol O-acetyltransferase. This enzyme participates in diterpenoid biosynthesis. References * EC 2.3.1 Enzymes of unknown structure {{2.3-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enokitake
''Flammulina filiformis'' is a species of agaric (gilled mushroom) in the family Physalacriaceae. It is well known for its role in Japanese cuisine, where it is called ''enokitake'' (榎茸, エノキタケ, ) and is widely cultivated in East Asia. Until recently, the species was considered to be conspecific with the European '' Flammulina velutipes'', but DNA sequencing has shown that the two are distinct. Taxonomy ''Flammulina filiformis'' was originally described from China in 2015 as a variety of ''F. velutipes'', based on ITS sequences. Further molecular research using a combination of different sequences has shown that ''F. filiformis'' and ''F. velutipes'' are distinct and should be recognized as separate species. Vernacular names The names ''enokitake'' ( 榎茸、 エノキタケ), ''enokidake'' (榎茸、 エノキダケ) and ''enoki'' ( 榎、 エノキ) are derived from the Japanese language. In Mandarin Chinese, the mushroom is called (', "gold needle mushroom") ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Escherichia Coli
''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escherichia'' that is commonly found in the lower intestine of warm-blooded organisms. Most ''E. coli'' strains are harmless, but some serotypes ( EPEC, ETEC etc.) can cause serious food poisoning in their hosts, and are occasionally responsible for food contamination incidents that prompt product recalls. Most strains do not cause disease in humans and are part of the normal microbiota of the gut; such strains are harmless or even beneficial to humans (although these strains tend to be less studied than the pathogenic ones). For example, some strains of ''E. coli'' benefit their hosts by producing vitamin K2 or by preventing the colonization of the intestine by pathogenic bacteria. These mutually beneficial relationships between ''E. col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
10-Deacetylbaccatin
10-Deacetylbaccatins are a series of closely related natural organic compounds isolated from the yew tree (Genera ''Taxus''). 10-Deacetylbaccatin III is a precursor to the anti-cancer drug docetaxel (Taxotere). 10-deacetylbaccatin III 10-''O''-acetyltransferase converts 10-deacetylbaccatin to baccatin III Baccatin III is an isolate from the yew tree (Genera ''Taxus''). Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol). In 2014, researchers reported introduction and expression of the endophytic fungal gene responsible for synt ...: :acetyl-CoA + 10-deacetylbaccatin III CoA + baccatin III External links * - 7-Epi-10-Deacetylbaccatin III * - 10-Deacetylbaccatin V * - 10-Deacetylbaccatin VI * - 13-Epi-10-Deacetylbaccatin III * - 13- -(2-Naphthyl)prop-2-enoyl2-debenzoyl-2-(4-methoxybenzoxyl)-10-deacetylbaccatin III * - 10-''N'',''N''-Dimethylglycyl-13- -(2-Naphthyl)prop-2-enoyl10-deacetylbaccatin III Benzoate esters Secondary alcohols Tertiary al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxadiene
Taxadiene (taxa-4,11-diene) is a diterpene. Taxadiene is the first committed intermediate in the synthesis of taxol. Six hydroxylation reactions, and a few others, are needed to convert taxadiene to baccatin III. Enzymatically, taxadiene is produced from geranylgeranyl pyrophosphate by taxadiene synthase. A biochemical gram-scale production of taxadiene has been reported in 2010 using genetically engineered ''Escherichia coli ''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escher ...''. References Dienes Taxanes Diterpenes {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxanes
Taxanes are a class of diterpenes. They were originally identified from plants of the genus ''Taxus'' (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer. Taxanes present difficulties in formulation as medicines because they are poorly soluble in water. Production As their name suggests, taxanes were first derived from natural sources, but some have been semisynthesized. Paclitaxel was originally derived from the Pacific yew tree. Taxanes are difficult to synthesize because of their numerous chiral centres—taxol has 11 of these. Recently, the presence of taxanes in the shells and leaves of ''Corylus avellana'' (the common hazel plant) has been reported. Mechanism of action The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubules are essential to cell division, and tax ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzoate Esters
Benzoic acid is a white (or colorless) solid organic compound with the formula , whose structure consists of a benzene ring () with a carboxyl () substituent. It is the simplest aromatic carboxylic acid. The name is derived from gum benzoin, which was for a long time its only source. Benzoic acid occurs naturally in many plants and serves as an intermediate in the biosynthesis of many secondary metabolites. Salts of benzoic acid are used as food preservatives. Benzoic acid is an important precursor for the industrial synthesis of many other organic substances. The salts and esters of benzoic acid are known as benzoates . History Benzoic acid was discovered in the sixteenth century. The dry distillation of gum benzoin was first described by Nostradamus (1556), and then by Alexius Pedemontanus (1560) and Blaise de Vigenère (1596). Justus von Liebig and Friedrich Wöhler determined the composition of benzoic acid. These latter also investigated how hippuric acid is related ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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