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Yage
''Banisteriopsis caapi'', also known as ayahuasca, caapi, soul vine, or yagé (yage), is a South American liana of the family Malpighiaceae. It is one half of ayahuasca, a decoction with a long history of its entheogenic (connecting to spirit) use and its status as a "plant teacher" among the Indigenous peoples of the Amazon rainforest. According to ''The CRC World Dictionary of Plant Names'' by Umberto Quattrocchi, the naming of the genus '' Banisteriopsis'' was dedicated to John Banister, a 17th-century English clergyman and naturalist. An earlier name for the genus was ''Banisteria'' and the plant is sometimes referred to as ''Banisteria caapi''. Other names include ''Banisteria quitensis'', ''Banisteriopsis inebrians'', and ''Banisteriopsis quitensis''. Description Caapi is a giant vine with characteristic white or pale pink flowers which most commonly appear in January, but are known to bloom infrequently. It resembles '' Banisteriopsis membranifolia'' and '' Banisteriops ...
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South America
South America is a continent entirely in the Western Hemisphere and mostly in the Southern Hemisphere, with a relatively small portion in the Northern Hemisphere at the northern tip of the continent. It can also be described as the southern Subregion#Americas, subregion of a single continent called Americas, America. South America is bordered on the west by the Pacific Ocean and on the north and east by the Atlantic Ocean; North America and the Caribbean Sea lie to the northwest. The continent generally includes twelve sovereign states: Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Guyana, Paraguay, Peru, Suriname, Uruguay, and Venezuela; two dependent territory, dependent territories: the Falkland Islands and South Georgia and the South Sandwich Islands; and one administrative division, internal territory: French Guiana. In addition, the ABC islands (Leeward Antilles), ABC islands of the Kingdom of the Netherlands, Ascension Island (dependency of Saint Helena, Asce ...
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Richard Spruce
Richard Spruce (10 September 1817 – 28 December 1893) was an English botanist specializing in bryology. One of the great Victorian botanical explorers, Spruce spent 15 years exploring the Amazon from the Andes to its mouth, and was one of the first Europeans to visit many of the places where he collected specimens. Spruce discovered and named a number of new plant species, and corresponded with some of the leading botanists of the nineteenth century. Early life and Career Richard Spruce was born near Ganthorpe, a small village near Castle Howard in Yorkshire. After training under his father, a local schoolmaster, Spruce began a career as a tutor and then as a mathematics master at St. Peter's School, York between 1839 and 1844. Spruce started his botanical collecting in Yorkshire about 1833. In 1834, at age 16, he drew up a neatly written list of all of the plants he had found on trips around Ganthorpe, focusing on bryophytes. Arranged alphabetically and containing 403 sp ...
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Harmine
Harmine is a beta-carboline and a harmala alkaloid. It occurs in a number of different plants, most notably the Syrian rue and '' Banisteriopsis caapi''. Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a Reversible inhibitor of monoamine oxidase A (RIMA). Harmine does not inhibit MAO-B. Harmine is also known as banisterin, banisterine, telopathin, telepathine, leucoharmine and yagin, yageine. Biosynthesis The coincident occurrence of β-carboline alkaloids and serotonin in ''Peganum harmala'' indicates the presence of two very similar, interrelated biosynthetic pathways, which makes it difficult to definitively identify whether free tryptamine or L-tryptophan is the precursor in the biosynthesis of harmine. However, it is postulated that L-tryptophan is the most likely precursor, with tryptamine existing as an intermediate in the pathway. The following figure shows the proposed biosynthetic scheme for harmine. The ...
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Indigenous Peoples
Indigenous peoples are culturally distinct ethnic groups whose members are directly descended from the earliest known inhabitants of a particular geographic region and, to some extent, maintain the language and culture of those original peoples. The term ''Indigenous'' was first, in its modern context, used by Europeans, who used it to differentiate the Indigenous peoples of the Americas from the Europeans, European settlers of the Americas and from the African diaspora, Sub-Saharan Africans who were brought to the Americas as Slavery, enslaved people. The term may have first been used in this context by Thomas Browne, Sir Thomas Browne in 1646, who stated "and although in many parts thereof there be at present swarms of ''Negroes'' serving under the ''Spaniard'', yet were they all transported from ''Africa'', since the discovery of ''Columbus''; and are not indigenous or proper natives of ''America''." Peoples are usually described as "Indigenous" when they maintain traditions ...
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N,N-dimethyltryptamine
''N'',''N''-Dimethyltryptamine (DMT or ''N'',''N''-DMT, SPL026) is a substituted tryptamine that occurs in many plants and animals, including human beings, and which is both a derivative and a structural analog of tryptamine. It is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. DMT has a rapid onset, intense effects, and a relatively short duration of action. For those reasons, DMT was known as the "business trip" during the 1960s in the United States, as a user could access the full depth of a psychedelic experience in considerably less time than with other substances such as LSD or psilocybin mushrooms. DMT can be inhaled, ingested, or injected and its effects depend on the dose, as well as the mode of administration. When inhaled or injected, the effects last a short period of time: about five to 15 minutes. Effects can last three hours or more when orally ingested along with a monoamine oxidase inhibitor (MAOI), such a ...
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Amazon Rainforest
The Amazon rainforest, Amazon jungle or ; es, Selva amazónica, , or usually ; french: Forêt amazonienne; nl, Amazoneregenwoud. In English, the names are sometimes capitalized further, as Amazon Rainforest, Amazon Forest, or Amazon Jungle. or Amazonia is a moist broadleaf tropical rainforest in the Amazon biome The Amazon biome ( pt, Bioma Amazônia) contains the Amazon rainforest, an area of tropical rainforest, and other ecoregions that cover most of the Amazon basin and some adjacent areas to the north and east. The biome contains blackwater and white ... that covers most of the Amazon basin of South America. This basin encompasses , of which are covered by the rainforest. This region includes territory belonging to nine nations and 3,344 formally acknowledged Indigenous territory (Brazil), indigenous territories. The majority of the forest is contained Amazônia Legal, within Brazil, with 60% of the rainforest, followed by Peruvian Amazonia, Peru with 13%, Amazon n ...
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John Banister (naturalist)
John Baptist Banister (1654 – May 1692) was an English clergyman and one of the first university-trained naturalists in North America. His primary focus was botany but he also studied insects and molluscs. He was sent out as a missionary chaplain by the garden-loving Bishop Henry Compton, with whom he soon established a correspondence. Banister was first in Barbados in the West Indies and then by April 1679 in Virginia, where, while serving a rector of the parish of Charles City he became one of Bishop Compton's most energetic plant collectors, "the first Virginia botanist of any note". Banister matriculated at Magdalen College, Oxford, where he could see and study the American plants grown from seed in the Oxford Physic Garden under the care of Dr. Robert Morison. From Virginia, his first letter to Dr Morison at the Oxford Physic Garden was dated 1679: in it he listed the bounty of American oaks that would supplement Britain's impoverished flora: dwarf, black, white, ...
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Dentate Gyrus
The dentate gyrus (DG) is part of the hippocampal formation in the temporal lobe of the brain, which also includes the hippocampus and the subiculum. The dentate gyrus is part of the hippocampal trisynaptic circuit and is thought to contribute to the formation of new episodic memories, the spontaneous exploration of novel environments and other functions. It is notable as being one of a select few brain structures known to have significant rates of adult neurogenesis in many species of mammals, from rodents to primates. Other sites of adult neurogenesis include the subventricular zone, the striatum and the cerebellum. However, whether significant neurogenesis exists in the adult human dentate gyrus has been a matter of debate. 2019 evidence has shown that adult neurogenesis does take place in the subventricular zone and in the subgranular zone of the dentate gyrus. Structure The dentate gyrus, like the hippocampus, consists of three distinct layers: an outer molecular l ...
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Antioxidant
Antioxidants are compounds that inhibit oxidation, a chemical reaction that can produce free radicals. This can lead to polymerization and other chain reactions. They are frequently added to industrial products, such as fuels and lubricants, to prevent oxidation, and to foods to prevent spoilage, in particular the rancidification of oils and fats. In cells, antioxidants such as glutathione, mycothiol or bacillithiol, and enzyme systems like superoxide dismutase, can prevent damage from oxidative stress. The only dietary antioxidants are vitamins A, C, and E, but the term ''antioxidant'' has also been applied to numerous other dietary compounds that only have antioxidant properties in vitro, with little evidence for antioxidant properties in vivo. Dietary supplements marketed as antioxidants have not been shown to maintain health or prevent disease in humans. History As part of their adaptation from marine life, terrestrial plants began producing non-marine anti ...
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Procyanidin B2
Procyanidin B2 is a B type proanthocyanidin. Its structure is (−)- Epicatechin-(4β→8)-(−)-epicatechin. Procyanidin B2 can be found in ''Cinchona pubescens'' (Chinchona: in the rind, bark, and cortex), in '' Cinnamomum verum'' (Ceylon cinnamon: in the rind, bark, and cortex), in '' Crataegus monogyna'' (Common hawthorn: in the flower and blossom), in '' Uncaria guianensis'' (Cat's claw: in the root), in '' Vitis vinifera'' (Common grape vine: in the leaf), in '' Litchi chinensis'' (litchi: in the pericarp), in the apple, and in ''Ecdysanthera utilis''. Procyanidin B2 can be converted into procyanidin A2 by radical oxidation using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals under neutral conditions. Procyanidin B2 has been shown to inhibit the formation of the advanced glycation end-products pentosidine Pentosidine is a biomarker for advanced glycation endproducts, or AGEs. It is a well characterized and easily detected member of this large class of compounds. Backgro ...
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Epicatechin
Catechin is a flavan-3-ol, a type of secondary metabolite providing antioxidant roles in plants. It belongs to the subgroup of polyphenols called flavonoids. The name of the catechin chemical family derives from ''catechu'', which is the tannic juice or boiled extract of ''Mimosa catechu'' (''Acacia catechu'' L.f). Chemistry Catechin possesses two benzene rings (called the A- and B-rings) and a dihydropyran heterocycle (the C-ring) with a hydroxyl group on carbon 3. The A-ring is similar to a resorcinol moiety while the B-ring is similar to a catechol moiety. There are two chiral centers on the molecule on carbons 2 and 3. Therefore, it has four diastereoisomers. Two of the isomers are in trans configuration and are called ''catechin'' and the other two are in cis configuration and are called ''epicatechin''. The most common catechin isomer is (+)-catechin. The other stereoisomer is (-)-catechin or ''ent''-catechin. The most common epicatechin isomer is (-)-epicatechin (also ...
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Proanthocyanidins
Proanthocyanidins are a class of polyphenols found in many plants, such as cranberry, blueberry, and grape seeds. Chemically, they are oligomeric flavonoids. Many are oligomers of catechin and epicatechin and their gallic acid esters. More complex polyphenols, having the same polymeric building block, form the group of tannins. Proanthocyanidins were discovered in 1947 by Jacques Masquelier, who developed and patented techniques for the extraction of oligomeric proanthocyanidins from pine bark and grape seeds. Often associated with prevention of urinary tract infections (UTIs) by consuming cranberries, grape seeds or red wine, proanthocyanidins have not been conclusively shown as effective for preventing or treating UTIs. Distribution in plants Proanthocyanidins, including the lesser bioactive and bioavailable polymers (four or more catechins), represent a group of condensed flavan-3-ols, such as procyanidins, prodelphinidins and propelargonidins. They can be found in many pl ...
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