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Uterine Microbiome
The uterine microbiome is the commensal, nonpathogenic, bacteria, viruses, yeasts/fungi present in a healthy uterus, amniotic fluid and endometrium and the specific environment which they inhabit. It has been only recently confirmed that the uterus and its tissues are not sterile. Due to improved 16S rRNA gene sequencing techniques, detection of bacteria that are present in low numbers is possible. Using this procedure that allows the detection of bacteria that cannot be cultured outside the body, studies of microbiota present in the uterus are expected to increase. Uterine microbiome and fertility Evidence shows that the presence of uterine bacterial 16S rRNA gene amplification is not the result of sampling or analysis error and deserves to be acknowledged. Concept of the sterile endometrium, and the uterine compartment in general, is outdated; although the true core uterine microbiome still needs to be assessed, and may vary across cultural and regional divides. Functi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbiome Analysis Flowchart
A microbiome () is the community of microorganisms that can usually be found living together in any given habitat. It was defined more precisely in 1988 by Whipps ''et al.'' as "a characteristic microbial community occupying a reasonably well-defined habitat which has distinct physio-chemical properties. The term thus not only refers to the microorganisms involved but also encompasses their theatre of activity". In 2020, an international panel of experts published the outcome of their discussions on the definition of the microbiome. They proposed a definition of the microbiome based on a revival of the "compact, clear, and comprehensive description of the term" as originally provided by Whipps ''et al.'', but supplemented with two explanatory paragraphs. The first explanatory paragraph pronounces the dynamic character of the microbiome, and the second explanatory paragraph clearly separates the term ''microbiota'' from the term ''microbiome''. The microbiota consists of all ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pregnancy
Pregnancy is the time during which one or more offspring develops (gestation, gestates) inside a woman, woman's uterus (womb). A multiple birth, multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but can also occur through assisted reproductive technology procedures. A pregnancy may end in a Live birth (human), live birth, a miscarriage, an Abortion#Induced, induced abortion, or a stillbirth. Childbirth typically occurs around 40 weeks from the start of the Menstruation#Onset and frequency, last menstrual period (LMP), a span known as the Gestational age (obstetrics), gestational age. This is just over nine months. Counting by Human fertilization#Fertilization age, fertilization age, the length is about 38 weeks. Pregnancy is "the presence of an implanted human embryo or fetus in the uterus"; Implantation (embryology), implantation occurs on average 8–9 days after fertilization. An ''embryo'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteroides
''Bacteroides'' is a genus of Gram-negative, obligate anaerobic bacteria. ''Bacteroides'' species are non endospore-forming bacilli, and may be either motile or nonmotile, depending on the species. The DNA base composition is 40–48% GC. Unusual in bacterial organisms, ''Bacteroides'' membranes contain sphingolipids. They also contain meso-diaminopimelic acid in their peptidoglycan layer. ''Bacteroides'' species are normally mutualistic, making up the most substantial portion of the mammalian gastrointestinal microbiota, where they play a fundamental role in processing of complex molecules to simpler ones in the host intestine. As many as 1010–1011 cells per gram of human feces have been reported. They can use simple sugars when available; however, the main sources of energy for ''Bacteroides'' species in the gut are complex host-derived and plant glycans. Studies indicate that long-term diet is strongly associated with the gut microbiome composition—those who eat pl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prevotella
''Prevotella'' is a genus of Gram-negative bacteria. ''Prevotella'' spp. are members of the oral, vaginal, and gut microbiota and are often recovered from anaerobic infections of the respiratory tract. These infections include aspiration pneumonia, lung abscess, pulmonary empyema, and chronic otitis media and sinusitis. They have been isolated from abscesses and burns in the vicinity of the mouth, bites, paronychia, urinary tract infection, brain abscesses, osteomyelitis, and bacteremia associated with upper respiratory tract infections. ''Prevotella'' spp. predominate in periodontal disease and periodontal abscesses. Role in gut microbiota Human gut is mainly inhabited by two phyla of bacteria—'' Bacillota'' and ''Bacteroidota'', the latter mostly dominated by ''Bacteroides'' and '' Prevotella'' genera. ''Prevotella'' and ''Bacteroides'' are thought to have had a common ancestor. Formally, the two genera were differentiated in 1990. However classification is still ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fusobacterium Nucleatum
''Fusobacterium nucleatum'' is a Gram negative, anaerobic oral bacterium, commensal to the human oral cavity, that plays a role in periodontal disease. This organism is commonly recovered from different monocultured microbial and mixed infections in humans and animals. In health and disease, it is a key component of periodontal plaque due to its abundance and its ability to coaggregate with other bacteria species in the oral cavity. Preterm births Research implicates periodontal disease caused by ''F. nucleatum'' with preterm births in humans. In many studies, ''F. nucleatum'' cells have been isolated from the amniotic fluid, placenta, and chorioamnionic membranes of women delivering prematurely. Moreover, laboratory mice inoculated (directly into the blood) with ''F. nucleatum'' have been found to deliver prematurely, and the pathology of the infection seems to mirror observations in humans. Together, this research provides evidence for a possible causal connection between ' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ureaplasma Parvum
''Ureaplasma parvum'' is a species of '' Ureaplasma'', a genus of bacteria belonging to the family Mycoplasmataceae. In Indonesia, ureaplasma parvum is most commonly contracted through contact with public toilets. ''Ureaplasma parvum'' was formerly known as ''Ureaplasma urealyticum biovar'' 1. ''Ureaplasma parvum'' has been identified as being a commensal in the uterus as part of the microbiome in healthy women of reproductive age. In addition, this pathogen may latently infect the chorionic villi tissues of pregnant women, thereby impacting pregnancy outcome. Classification ''Ureaplasma spp''. are one of the smallest known clonal bacteria. They are closely related to mycoplasmas as they lack a peptidoglycan cell wall, metabolize cholesterol, and require urea for ATP synthesis. The Ureaplasma genus has 14 serotypes A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Escherichia
''Escherichia'' () is a genus of Gram-negative, non- spore-forming, facultatively anaerobic, rod-shaped bacteria from the family Enterobacteriaceae. In those species which are inhabitants of the gastrointestinal tracts of warm-blooded animals, ''Escherichia'' species provide a portion of the microbially derived vitamin K for their host. A number of the species of ''Escherichia'' are pathogenic. The genus is named after Theodor Escherich, the discoverer of ''Escherichia coli''. ''Escherichia'' are facultative aerobes, with both aerobic and anaerobic growth, and an optimum temperature of 37 °C. ''Escherichia'' are usually motile by flagella, produce gas from fermentable carbohydrates, and do not decarboxylate lysine or hydrolyze arginine. Species include '' E. albertii'', '' E. fergusonii'', '' E. hermannii'', '' E. marmotae'' and most notably, the model organism and clinically relevant '' E. coli''. ''Shimwellia blattae'' was formerly classified in this genus. Pathogenesis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Escherichia Coli
''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus '' Escherichia'' that is commonly found in the lower intestine of warm-blooded organisms. Most ''E. coli'' strains are harmless, but some serotypes ( EPEC, ETEC etc.) can cause serious food poisoning in their hosts, and are occasionally responsible for food contamination incidents that prompt product recalls. Most strains do not cause disease in humans and are part of the normal microbiota of the gut; such strains are harmless or even beneficial to humans (although these strains tend to be less studied than the pathogenic ones). For example, some strains of ''E. coli'' benefit their hosts by producing vitamin K2 or by preventing the colonization of the intestine by pathogenic bacteria. These mutually beneficial relationships between ''E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Candida Albicans
''Candida albicans'' is an opportunistic pathogenic yeast that is a common member of the human gut flora. It can also survive outside the human body. It is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults. It is usually a commensal organism, but it can become pathogenic in immunocompromised individuals under a variety of conditions. It is one of the few species of the genus '' Candida'' that causes the human infection candidiasis, which results from an overgrowth of the fungus. Candidiasis is, for example, often observed in HIV-infected patients. ''C. albicans'' is the most common fungal species isolated from biofilms either formed on (permanent) implanted medical devices or on human tissue. ''C. albicans'', ''C. tropicalis'', ''C. parapsilosis'', and ''C. glabrata'' are together responsible for 50–90% of all cases of candidiasis in humans. A mortality rate of 40% has been reported for patients with systemic candidiasis due to ''C. albicans' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epstein Barr Virus Virions EM 10
The surname Epstein ( yi, עפּשטײן, Epshteyn) is one of the oldest Ashkenazi Jewish family names. It is probably derived from the German town of Eppstein, in Hesse; the place-name was probably derived from Gaulish ''apa'' ("water", in the sense of a river) and German '' -stein'' ("stone", in the sense of a hill). Some people with this name include: Arts * Alex Epstein, Israeli writer * Barbara Epstein, literary editor * Brian Epstein (1934–1967), businessman, manager of the Beatles * Daniel Epstein (pianist) * Daniel Mark Epstein, biographer and poet * Deborah Epstein, French-American singer-songwriter more commonly known as SoShy * Dena Epstein (1916–2013), American music librarian, writer, and musicologist * Edward Jay Epstein, author and early critic of the Warren Commission * Howie Epstein, bass guitarist * Jacob Epstein, sculptor * Jake Epstein, Canadian actor * Jason Epstein, publisher who popularized the trade paperback * Jean Epstein, film director * Joseph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pittsburgh
The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the university's central administration and around 28,000 undergraduate and graduate students. The 132-acre Pittsburgh campus includes various historic buildings that are part of the Schenley Farms Historic District, most notably its 42-story Gothic revival centerpiece, the Cathedral of Learning. Pitt is a member of the Association of American Universities and is classified among "R1: Doctoral Universities – Very high research activity". It is the second-largest non-government employer in the Pittsburgh metropolitan area. Pitt traces its roots to the Pittsburgh Academy founded by Hugh Henry Brackenridge in 1787. While the city was still on the edge of the American frontier at the time, Pittsburgh's rapid growth meant that a proper university w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
