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Thiosulfate Sulfurtransferase
Rhodanese, also known as rhodanase, thiosulfate sulfurtransferase, thiosulfate cyanide transsulfurase, and thiosulfate thiotransferase, at the International Union of Biochemistry and Molecular Biology is a that detoxifies (CN−) by converting it to (SCN−). This reaction takes place in two steps. The diagram on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitochondrion
A mitochondrion (; ) is an organelle found in the cells of most Eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects. The term ''mitochondrion'' was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase coined by Philip Siekevitz in a 1957 article of the same name. Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells). A large number of unicellular organisms, such as microsporidia, parabasalids and diplomonads, have reduced or transformed their mitochondria into other structures. One eukaryote, ''Monocercomonoides'', is known to have completely lost its mitochondria, and one multicellular organism, '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DUSP2
Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the ''DUSP2'' gene. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/ threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the ''MAPK3'' gene. Function The protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
USP8
Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the ''USP8'' gene. Interactions USP8 has been shown to interact with RNF41 E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the ''RNF41'' gene. Function The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be inv ... and STAM2. References Further reading * * * * * * * * * * * * * {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TST (gene) homology domains), suggesting these domains have a common evolutionary origin.
Thiosulfate sulfurtransferase is an enzyme that in humans is encoded by the ''TST'' gene. The product of this gene is a mitochondrial matrix enzyme that is encoded by the nucleus. It may play roles in cyanide detoxification, the formation of iron-sulfur proteins, and the modification of sulfur-containing enzymes. The gene product contains two highly conservative domains (rhodanese Rhodanese, also known as rhodanase, thiosulfate sulfurtransferase, thiosulfate cyanide transsulfurase, and thiosulfate thiotransferase, References Further reading * * * * * * * * * * * * * * * * * * * {{gene-22-stub ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MPST
In enzymology, a 3-mercaptopyruvate sulfurtransferase () is an enzyme that catalyzes the chemical reactions of 3-mercaptopyruvate. This enzyme belongs to the family of transferases, specifically the sulfurtransferases. This enzyme participates in cysteine metabolism. It is encoded by the ''MPST'' gene. The enzyme is of interest because it provides a pathway for detoxification of cyanide, especially since it occurs widely in the cytosol and distributed broadly. Nomenclature The systematic name of this enzyme class is 3-mercaptopyruvate:cyanide sulfurtransferase. This enzyme is also called beta-mercaptopyruvate sulfurtransferase and in the older literature, human liver rhodanese. Structure Gene The ''MPST'' gene lies on the chromosome location of 22q12.3 and consists of 6 exons. Alternatively spliced transcript variants encoding the same protein have been identified. Protein The encoded cytoplasmic protein is a member of the rhodanese family but is not rhodanese i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MOCS3
Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the ''MOCS3'' gene. Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase, encoded by ''MOCS2''/''Mocs2'' in mammals). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene Pseudogenes are nonfunctional segments of DNA that resemble functional genes. Most arise as superfluous copies of functional genes, either directly by DNA duplication or indirectly by Reverse transcriptase, reverse transcription of an mRNA trans ... of this gene is present on chromosome 14. References Further reading * * * * * * * * * * {{gene-20-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
KAT (gene)
Kat or KAT may refer to: People * Kat Alano (born 1985), Anglo-Filipino model, actress, and television presenter/VJ in the Philippines * Kat Ashley (c1502–1565), governess to Queen Elizabeth I * Kat Bjelland (born 1963), American musician * Kat Blaque (born 1990), American YouTuber, activist, and artist * Kat Cressida (born 1968), American actress * Kat DeLuna (born 1987), singer-songwriter * Kat Foster (born 1978), American actress * Kat Graham (born 1989), American actress, singer, songwriter, record producer, dancer, and model * Kat Stewart (born 1972), Australian actress * Kat Swift (fl. 2008), American politician and activist * Karl-Anthony Towns (born 1995), American basketball player * Kat Von D (born 1982), tattoo artist * The Great Kat, world's fastest female guitarist * Kat Dennings, stage name of American actress Katherine Victoria Litwack (born 1986) * The Kat, stage name of Stacy Carter (born 1970), former professional wrestling personality Fictional characters * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DUSP7
Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the ''DUSP7'' gene. Function Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to de-phosphorylate both tyrosine () and serine / threonine () residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses. It is known to bind and dephosphorylate ErkII, and as it, along with the other members of the DUSP family expresses high selectively for MAP kinase A mitogen- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
