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Tryptophol
Tryptophol is an aromatic alcohol that induces sleep in humans. It is found in wine as a secondary product of ethanol fermentation. It was first described by Felix Ehrlich in 1912. It is also produced by the trypanosomal parasite in sleeping sickness. It forms in the liver as a side-effect of disulfiram treatment. Natural occurrences Tryptophol can be found in ''Pinus sylvestris'' needles or seeds. It is produced by the trypanosomal parasite (''Trypanosoma brucei'') in sleeping sickness (African trypanosomiasis). Tryptophol is found in wine and beer as a secondary product of ethanol fermentation (a product also known as congener) by ''Saccharomyces cerevisiae''. It is also an autoantibiotic produced by the fungus ''Candida albicans. It can also be isolated from the marine sponge ''Ircinia spiculosa''. Metabolism Biosynthesis It was first described by Felix Ehrlich in 1912. Ehrlich demonstrated that yeast attacks the natural amino acids essentially by splitting off carbon dio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tryptophol Glucoside
Tryptophol is an aromatic alcohol that induces sleep in humans. It is found in wine as a secondary product of ethanol fermentation. It was first described by Felix Ehrlich in 1912. It is also produced by the trypanosomal parasite in sleeping sickness. It forms in the liver as a side-effect of disulfiram treatment. Natural occurrences Tryptophol can be found in ''Pinus sylvestris'' needles or seeds. It is produced by the trypanosomal parasite (''Trypanosoma brucei'') in sleeping sickness (African trypanosomiasis). Tryptophol is found in wine and beer as a secondary product of ethanol fermentation (a product also known as congener) by ''Saccharomyces cerevisiae''. It is also an autoantibiotic produced by the fungus ''Candida albicans. It can also be isolated from the marine sponge ''Ircinia spiculosa''. Metabolism Biosynthesis It was first described by Felix Ehrlich in 1912. Ehrlich demonstrated that yeast attacks the natural amino acids essentially by splitting off carbon dio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tryptophol Galactoside
Tryptophol is an aromatic alcohol that induces sleep in humans. It is found in wine as a secondary product of ethanol fermentation. It was first described by Felix Ehrlich in 1912. It is also produced by the trypanosomal parasite in sleeping sickness. It forms in the liver as a side-effect of disulfiram treatment. Natural occurrences Tryptophol can be found in ''Pinus sylvestris'' needles or seeds. It is produced by the trypanosomal parasite (''Trypanosoma brucei'') in sleeping sickness (African trypanosomiasis). Tryptophol is found in wine and beer as a secondary product of ethanol fermentation (a product also known as congener) by ''Saccharomyces cerevisiae''. It is also an autoantibiotic produced by the fungus ''Candida albicans. It can also be isolated from the marine sponge ''Ircinia spiculosa''. Metabolism Biosynthesis It was first described by Felix Ehrlich in 1912. Ehrlich demonstrated that yeast attacks the natural amino acids essentially by splitting off carbon dio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tryptophol Acetate
Tryptophol is an aromatic alcohol that induces sleep in humans. It is found in wine as a secondary product of ethanol fermentation. It was first described by Felix Ehrlich in 1912. It is also produced by the trypanosomal parasite in sleeping sickness. It forms in the liver as a side-effect of disulfiram treatment. Natural occurrences Tryptophol can be found in ''Pinus sylvestris'' needles or seeds. It is produced by the trypanosomal parasite (''Trypanosoma brucei'') in sleeping sickness (African trypanosomiasis). Tryptophol is found in wine and beer as a secondary product of ethanol fermentation (a product also known as congener) by ''Saccharomyces cerevisiae''. It is also an autoantibiotic produced by the fungus ''Candida albicans. It can also be isolated from the marine sponge ''Ircinia spiculosa''. Metabolism Biosynthesis It was first described by Felix Ehrlich in 1912. Ehrlich demonstrated that yeast attacks the natural amino acids essentially by splitting off carbon dio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tryptophan
Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins. Tryptophan contains an α-amino group, an α- carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent. It is essential in humans, meaning that the body cannot synthesize it and it must be obtained from the diet. Tryptophan is also a precursor to the neurotransmitter serotonin, the hormone melatonin, and vitamin B3. It is encoded by the codon UGG. Like other amino acids, tryptophan is a zwitterion at physiological pH where the amino group is protonated (–; pKa = 9.39) and the carboxylic acid is deprotonated ( –COO−; pKa = 2.38). Humans and many animals cannot synthesize tryptophan: they need to obtain it through their diet, making it an essential amino acid. Function Amino acids, including tryptophan, are used as building blocks in protein biosynthesis, and proteins are required to sustain life. Man ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Felix Ehrlich
Felix Ehrlich (16 June 1877 in Harriehausen (today incorporated into Bad Gandersheim) – 23 January 1942 in Obernigk near Breslau) was a German chemist and biochemist. Life and work Felix Ehrlich studied in Berlin and Munich. After receiving his doctorate in 1900, he worked at the Institute of Sugar Industry in Berlin. In 1906 he obtained his diploma in chemistry. From 1909 he worked as professor in Breslau, and later as director of the Institute on Biotechnology and Agriculture. Ehrlich discovered the amino acid isoleucine in hemoglobin in 1903, developed a process for resolving racemic amino acids in 1906, described the formation of fusel oils by fermentation, amino acid during alcoholic fermentation in 1905 and worked on the structure of pectins. Ehrlich demonstrated that yeast attacks the natural amino acids essentially by splitting off carbon dioxide and replacing the amino group with hydroxyl. By this reaction, the tryptophan gives rise to tryptophol. Honours 1931 Emi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosoma Brucei
''Trypanosoma brucei'' is a species of parasitic Kinetoplastida, kinetoplastid belonging to the genus ''Trypanosoma'' that is present in sub-Saharan Africa. Unlike other protozoan parasites that normally infect blood and tissue cells, it is exclusively extracellular and inhabits the blood plasma and body fluids. It causes deadly vector-borne diseases: African trypanosomiasis or sleeping sickness in humans, and animal trypanosomiasis or ''nagana'' in cattle and horses. It is a species complex grouped into three subspecies: ''T. b. brucei'', ''T. b. gambiense'' and ''T. b. rhodesiense''. The first is a parasite of non-human mammals and causes ''nagana'', while the latter two are zoonotic infecting both humans and animals and cause African trpanosomiasis. ''T. brucei'' is transmitted between mammal hosts by an insect Vector (epidemiology), vector belonging to different species of tsetse fly (''Glossina''). Transmission occurs by biting during the insect's blood meal. The parasites un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indole-3-acetic Acid
Indole-3-acetic acid (IAA, 3-IAA) is the most common naturally occurring plant hormone of the auxin class. It is the best known of the auxins, and has been the subject of extensive studies by plant physiologists. IAA is a derivative of indole, containing a carboxymethyl substituent. It is a colorless solid that is soluble in polar organic solvents. Biosynthesis IAA is predominantly produced in cells of the apex (bud) and very young leaves of a plant. Plants can synthesize IAA by several independent biosynthetic pathways. Four of them start from tryptophan, but there is also a biosynthetic pathway independent of tryptophan. Plants mainly produce IAA from tryptophan through indole-3-pyruvic acid. IAA is also produced from tryptophan through indole-3-acetaldoxime in ''Arabidopsis thaliana''. In rats, IAA is a product of both endogenous and colonic microbial metabolism from dietary tryptophan along with tryptophol. This was first observed in rats infected by ''Trypanosoma bruc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indole
Indole is an aromatic heterocyclic organic compound with the formula C8 H7 N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. As an intercellular signal molecule, indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence. The amino acid tryptophan is an indole derivative and the precursor of the neurotransmitter serotonin. General properties and occurrence Indole is a solid at room temperature. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell, and is a constituent of many perfumes. It also occurs in coal tar. The corresponding substituent is called indolyl. Indole undergoes electrophilic substitution, mainly at position 3 (see diagra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disulfiram
Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol consumption. Disulfiram plus alcohol, even small amounts, produces flushing, throbbing in the head and neck, a throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, fast heart rate, low blood pressure, fainting, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, abnormal heart rhythms, heart attack, acute congestive heart failure, unconsciousness, convulsions, and death. In the body, alcohol is converted to acetaldehyde, which is then broken down by acetaldehyde dehydrogenase. When the dehydrogenase ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
African Trypanosomiasis
African trypanosomiasis, also known as African sleeping sickness or simply sleeping sickness, is an insect-borne parasitic infection of humans and other animals. It is caused by the species ''Trypanosoma brucei''. Humans are infected by two types, ''Trypanosoma brucei gambiense'' (TbG) and '' Trypanosoma brucei rhodesiense'' (TbR). TbG causes over 98% of reported cases. Both are usually transmitted by the bite of an infected tsetse fly and are most common in rural areas. Initially, the first stage of the disease is characterized by fevers, headaches, itchiness, and joint pains, beginning one to three weeks after the bite. Weeks to months later, the second stage begins with confusion, poor coordination, numbness, and trouble sleeping. Diagnosis is by finding the parasite in a blood smear or in the fluid of a lymph node. A lumbar puncture is often needed to tell the difference between first- and second-stage disease. If the disease is not treated quickly it can lead to death. P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethanol Fermentation
Ethanol fermentation, also called alcoholic fermentation, is a biological process which converts sugars such as glucose, fructose, and sucrose into cellular energy, producing ethanol and carbon dioxide as by-products. Because yeasts perform this conversion in the absence of oxygen, alcoholic fermentation is considered an anaerobic process. It also takes place in some species of fish (including goldfish and carp) where (along with lactic acid fermentation) it provides energy when oxygen is scarce. Ethanol fermentation is the basis for alcoholic beverages, ethanol fuel and bread dough rising. Biochemical process of fermentation of sucrose The chemical equations below summarize the fermentation of sucrose (C12H22O11) into ethanol (C2H5OH). Alcoholic fermentation converts one mole of glucose into two moles of ethanol and two moles of carbon dioxide, producing two moles of ATP in the process. :C6H12O6 → 2 C2H5OH + 2 CO2 Sucrose is a sugar composed of a glucose linked to a fru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhizoctonia
''Rhizoctonia'' is a genus of fungi in the order Cantharellales. Species form thin, effused, corticioid basidiocarps (fruit bodies), but are most frequently found in their sterile, anamorphic state. ''Rhizoctonia'' species are saprotrophic, but some are also facultative plant pathogens, causing commercially important crop diseases. Some are also endomycorrhizal associates of orchids. The genus name was formerly used to accommodate many superficially similar, but unrelated fungi. Taxonomy History Anamorphs ''Rhizoctonia'' was introduced in 1815 by French mycologist Augustin Pyramus de Candolle for anamorphic plant pathogenic fungi that produce both hyphae and sclerotia. The name is derived from Ancient Greek, ῥίζα (''rhiza'', "root") + κτόνος (''ktonos'', "murder"), and de Candolle's original species, ''Rhizoctonia crocorum'' (teleomorph ''Helicobasidium purpureum''), is the causal agent of violet root rot of carrots and other root vegetables. Subsequent authors added ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
