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Tryptophan-rich Sensory Protein
Tryptophan-rich sensory proteins (TspO) are a family of proteins that are involved in transmembrane cell signalling, signalling. In either prokaryotes or mitochondria they are localized to the outer mitochondrial membrane, outer membrane, and have been shown to Molecular binding, bind and transport dicarboxylic tetrapyrrole reaction intermediate, intermediates of the haem biosynthetic pathway. They are associated with the major outer mitochondrial membrane, outer membrane porin (protein), porins (in prokaryotes) and with the VDAC, voltage-dependent anion channel (in mitochondria). TspO of ''Rhodobacter sphaeroides'' is involved in signal transduction, functioning as a negative regulator of the gene expression, expression of some photosynthesis genes (PpsR/AppA repressor/antirepressor regulon). This down-regulation is believed to be in response to oxygen levels. TspO works through (or modulates) the PpsR/AppA system and acts upstream and downstream (DNA), upstream of the site of act ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Signalling
In biology, cell signaling (cell signalling in British English) or cell communication is the ability of a cell to receive, process, and transmit signals with its environment and with itself. Cell signaling is a fundamental property of all cellular life in prokaryotes and eukaryotes. Signals that originate from outside a cell (or extracellular signals) can be physical agents like mechanical pressure, voltage, temperature, light, or chemical signals (e.g., small molecules, peptides, or gas). Cell signaling can occur over short or long distances, and as a result can be classified as autocrine, juxtacrine, intracrine, paracrine, or endocrine. Signaling molecules can be synthesized from various biosynthetic pathways and released through passive or active transports, or even from cell damage. Receptors play a key role in cell signaling as they are able to detect chemical signals or physical stimuli. Receptors are generally proteins located on the cell surface or within the interio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
