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Trimetazidine
Trimetazidine ( IUPAC: 1-(2,3,4-trimethoxybenzyl)piperazine) is a drug for angina pectoris (chest pain associated with blood flow to the heart) sold under many brand names. Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France). It is an anti-ischemic (antianginal) metabolic agent of the fatty acid oxidation inhibitor class, meaning that it improves myocardial glucose utilization through inhibition of fatty acid metabolism. Medical uses Trimetazidine is usually prescribed as a long-term treatment of angina pectoris, and in some countries (including France) for tinnitus and dizziness. It is taken twice a day. In 2012, the European Medicines Agency (EMA) finished a review of benefits and risks of trimetazidine and recommended restricting use of trimetazidine-containing medicines to just as an additional treatment of angina pectoris in cases of inadequate control by or intolerance to first-line a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sun Yang
Sun Yang (; ; born 1 December 1991) is a Chinese Olympic and world-record-holding competitive swimmer. In 2012, Sun became the first Chinese athlete to win an Olympic swimming gold medal. Sun is the first male swimmer in history to earn Olympic and World Championship gold medals at every freestyle distance from 200 to 1500 metres. A three-time Olympic gold medalist and eleven-time world champion, he is the most decorated Chinese swimmer in history. In 2017, NBC Sports described him as "arguably the greatest freestyle swimmer of all time". In September 2018, Sun was involved in an incident during an out-of-competition anti-doping test at his home. FINA concluded that Sun did not commit an anti-doping rule violation. On 28 February 2020, Court of Arbitration for Sport (CAS) delivered its findings, overturning FINA's decision and banning Sun for eight years for tampering with the doping control process. However CAS also ruled that Sun would not officially lose any of his medal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madisyn Cox
Madisyn Cox (born May 30, 1995) is an American former swimmer specialising in individual medley events. College career For the Texas Longhorns she was named the 2015 and 2017 Big 12 Conference Swimmer of the Year. She is a 10-time All-American. International career 2014 She competed in the 4 × 200-meter freestyle relay at the Short Course World Championships. 2015 Cox took silver in 200-meter individual medley at the 2015 Summer Universiade. 2016 She won bronze in the 400-meter individual medley at the 2016 Short Course World Championships. She had originally finished 4th, but was elevated to bronze, along with teammate Ella Eastin being elevated to silver, when Ánh Viên Nguyễn was disqualified from second place. 2017 Cox qualified to swim the 200-meter individual medley at the World Championships after finishing second at the 2017 US Nationals. She went on to win the bronze medal in Budapest with a time of 2:09.71. She also won a gold medal as a prelim sw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laboratoires Servier
Servier Laboratories (French: Laboratoires Servier, often abbreviated to Servier) is an international pharmaceutical company governed by a non-profit foundation, with its headquarters in France (Suresnes). The consolidated turnover for the 2018 financial year was €4.2 billion. Servier is the leading French independent pharmaceutical company, and the second largest French pharmaceutical company worldwide. It has branches in 149 countries, achieving 82% of its sales outside France. The company reportedly invests a little under 25% of its turnover in research and development, which occupies 3,000 of its 22,000 employees worldwide. The company's production sites produced 853 million drug boxes in 2013. The Servier Clinical Support Unit in Gidy (near Orléans), which produces drugs for clinical trials, is the largest unit of its kind in Europe. Servier Laboratories is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA). In 2018, Servie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatty Acid Oxidation Inhibitor
Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure. Drugs * CPT-I inhibitors: Etomoxir, Oxfenicine, Perhexiline CPT-I ( carnitine palmitoyl transferase) converts fatty acyl-CoA to fatty acyl-carnitine. * Carnitine biosynthesis inhibitor: Mildronate * 3-KAT inhibitors: Trimetazidine 3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation In biochemistry and metabolism, beta-oxidation is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA, which enters the citric acid cycle .... * pFOX directly inhibits fatty acid beta-oxidation.Partial fatty acid oxidation inhibitors: a potentially new class of drugs for heart failure; European Journal of Heart Failure 4 2002. 3-6; http://eurjhf.oxfordjournals.org/content/4/1/3.full.pdf+h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science & Justice
''Science & Justice'' is a peer-reviewed scientific journal of forensics published by Elsevier on behalf of the Forensic Science Society and the International Society for Forensic Genetics. The journal was established in 1960 as the ''Journal of the Forensic Science Society'' and obtained its current name in 1995. One notable article was an analysis of the assassination of John F. Kennedy, which disputed the conclusion of the 1982 United States National Academy of Sciences report that the House Select Committee on Assassinations The United States House of Representatives Select Committee on Assassinations (HSCA) was established in 1976 to investigate the assassinations of John F. Kennedy and Martin Luther King, Jr. in 1963 and 1968, respectively. The HSCA completed its ... finding of a fourth shot in acoustical evidence was incorrect. A later article re-analyzed the acoustic synchronization evidence, rebutting this argument as well as correcting errors in the 1982 report, whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Florida
The University of Florida (Florida or UF) is a public land-grant research university in Gainesville, Florida. It is a senior member of the State University System of Florida, traces its origins to 1853, and has operated continuously on its Gainesville campus since September 1906. After the Florida state legislature's creation of performance standards in 2013, the Florida Board of Governors designated the University of Florida as a "preeminent university". For 2022, '' U.S. News & World Report'' ranked Florida as the fifth (tied) best public university and 28th (tied) best university in the United States. The University of Florida is the only member of the Association of American Universities in Florida and is classified among "R1: Doctoral Universities – Very high research activity". The university is accredited by the Southern Association of Colleges and Schools (SACS). It is the third largest Florida university by student population,Nathan Crabbe, UF is no longer lar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Popular Science
''Popular Science'' (also known as ''PopSci'') is an American digital magazine carrying popular science content, which refers to articles for the general reader on science and technology subjects. ''Popular Science'' has won over 58 awards, including the American Society of Magazine Editors awards for its journalistic excellence in 2003 (for General Excellence), 2004 (for Best Magazine Section), and 2019 (for Single-Topic Issue). With roots beginning in 1872, ''Popular Science'' has been translated into over 30 languages and is distributed to at least 45 countries. Early history '' The Popular Science Monthly'', as the publication was originally called, was founded in May 1872 by Edward L. Youmans to disseminate scientific knowledge to the educated layman. Youmans had previously worked as an editor for the weekly ''Appleton's Journal'' and persuaded them to publish his new journal. Early issues were mostly reprints of English periodicals. The journal became an outlet for writin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RUSADA
The Russian Anti-Doping Agency (RUSADA; russian: Российское антидопинговое агентство, РУСАДА), established in January 2008, is the Russian National Anti-Doping Organisation (NADO), affiliated with (but suspended from, since 2015) the World Anti-Doping Agency (WADA). History It was established under the rules of the UNESCO International Convention against Doping in Sport approved at the 33rd UNESCO General Conference on 19 October 2005, and ratified by the Russian Federation on 26 December 2006. As the Russian NADO, the organization operates the anti-doping programs for Russian Olympic and Paralympic sport. The organization's WADA accreditation, which under normal circumstances would have been valid until 2017, is currently suspended due to compliance issues discussed below. The agency website claims they are an organization independent from the Russian government. The Acting Director-General of RUSADA, since at least October 2020, is Mik ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
USA Today
''USA Today'' (stylized in all uppercase) is an American daily middle-market newspaper and news broadcasting company. Founded by Al Neuharth on September 15, 1982, the newspaper operates from Gannett's corporate headquarters in Tysons, Virginia. Its newspaper is printed at 37 sites across the United States and at five additional sites internationally. The paper's dynamic design influenced the style of local, regional, and national newspapers worldwide through its use of concise reports, colorized images, informational graphics, and inclusion of popular culture stories, among other distinct features. With an average print circulation of 159,233 as of 2022, a digital-only subscriber base of 504,000 as of 2019, and an approximate daily readership of 2.6 million, ''USA Today'' is ranked as the first by circulation on the list of newspapers in the United States. It has been shown to maintain a generally center-left audience, in regards to political persuasion. ''USA Today ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reuters
Reuters ( ) is a news agency owned by Thomson Reuters Corporation. It employs around 2,500 journalists and 600 photojournalists in about 200 locations worldwide. Reuters is one of the largest news agencies in the world. The agency was established in London in 1851 by the German-born Paul Reuter. It was acquired by the Thomson Corporation of Canada in 2008 and now makes up the media division of Thomson Reuters. History 19th century Paul Reuter worked at a book-publishing firm in Berlin and was involved in distributing radical pamphlets at the beginning of the Revolutions in 1848. These publications brought much attention to Reuter, who in 1850 developed a prototype news service in Aachen using homing pigeons and electric telegraphy from 1851 on, in order to transmit messages between Brussels and Aachen, in what today is Aachen's Reuters House. Reuter moved to London in 1851 and established a news wire agency at the London Royal Exchange. Headquartered in London, R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kamila Valieva
Kamila Valeryevna Valieva (russian: Камила Валерьевна Валиева; born 26 April 2006) is a Russian figure skater. She is the 2022 European champion, 2021 Rostelecom Cup champion, 2021 Skate Canada International champion, 2022 Russian national champion, and 2021 Russian National silver medalist. She is also a provisional 2022 Olympic champion in the team event pending the conclusion of a WADA investigation. During the 2022 Winter Olympics, a sample that Valieva had submitted for a drug test in December tested positive for trimetazidine, which is banned in sports competition for increasing endurance. As of mid-February investigations were ongoing. Valieva is the current world record holder for the women's short program, free skating and total scores. She has set nine world records during her career. She is the first female skater to break the 250-, 260- and 270-point thresholds in the total score (all within one season), the first to break the 170- and 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Associated Press
The Associated Press (AP) is an American non-profit news agency headquartered in New York City. Founded in 1846, it operates as a cooperative, unincorporated association. It produces news reports that are distributed to its members, U.S. newspapers and broadcasters. The AP has earned 56 Pulitzer Prizes, including 34 for photography, since the award was established in 1917. It is also known for publishing the widely used ''AP Stylebook''. By 2016, news collected by the AP was published and republished by more than 1,300 newspapers and broadcasters, English, Spanish, and Arabic. The AP operates 248 news bureaus in 99 countries. It also operates the AP Radio Network, which provides newscasts twice hourly for broadcast and satellite radio and television stations. Many newspapers and broadcasters outside the United States are AP subscribers, paying a fee to use AP material without being contributing members of the cooperative. As part of their cooperative agreement with the AP, mos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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