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Temephos
Temefos or temephos (trade name Abate) is an organophosphate larvicide used to treat water infested with disease-carrying insects (including mosquitoes, midges, and black fly larvae) and crustaceans (copepods). As with other organophosphates, temephos affects the central nervous system through inhibition of cholinesterase. In larvae, this results in death before reaching the adult stage. In the developing world where the vector-borne disease dengue fever is endemic, temephos is widely used and applied by both private and public pest control in areas of standing water where the ''Aedes aegypti'' mosquito breeds, in order to reduce the population of this disease-carrying insect. Temephos is also used in the Guinea Worm Eradication Program to kill the copepods that carry guinea worm larvae. Resistance to temephos by ''A. aegypti'' has been seen in Brazil. The Brazilian Aedes aegypti resistance monitoring program detected temephos resistance in ''A. aegypti'' populations from se ...
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Organophosphate
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered as esters of phosphoric acid. Organophosphates are best known for their use as pesticides. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added to the final product physically rather than by chemical bond. Due to this, OPEs leak in ...
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Larvicide
A larvicide (alternatively larvacide) is an insecticide that is specifically targeted against the larval life stage of an insect. Their most common use is against mosquitoes. Larvicides may be contact poisons, stomach poisons, growth regulators, or (increasingly) biological control agents. Biological agents The biological control agent ''Bacillus thuringiensis'', also known as ''Bt'', is a bacterial disease specific to Lepidopteran caterpillars. ''Bacillus thuringiensis israelensis'', also known as ''Bti'', and ''Bacillus sphaericus'', which affect larval mosquitoes and some midges, have come into increasing use in recent times. ''Bti'' and ''B. sphaericus'' are both naturally occurring soil bacterium registered as larvicides under the names Bactivec, Bacticide, Aquabac, Teknar, Vectobac, LarvX, and VectoLex CG. Typically in granular form, pellets are distributed on the surface of stagnant water locations. When the mosquito larvae ingest the bacteria, crystallized toxins are prod ...
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Organophosphate Insecticides
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or Aryl, aromatic substituents. They can be considered as esters of phosphoric acid. Organophosphates are best known for their use as pesticides. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and adenosine triphosphate, ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added to the final product physically rather than by chemical bond. ...
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Acetylcholinesterase Inhibitors
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from Hydrolysis, breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, Autonomic ganglion, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being Butyrylcholinesterase#Inhibitors, butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase, cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP, tetraethyl pyrophosphate (TEPP) and sarin inhibit cholinesterases, enzymes that hydrolyze the ...
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BASF
BASF SE (), an initialism of its original name , is a European Multinational corporation, multinational company and the List of largest chemical producers, largest chemical producer in the world. Its headquarters are located in Ludwigshafen, Germany. BASF comprises subsidiary, subsidiaries and joint ventures in more than 80 countries, operating six integrated production sites and 390 other production sites across Europe, Asia, Australia, the Americas and Africa. BASF has customers in over 190 countries and supplies products to a wide variety of industries. Despite its size and global presence, BASF has received relatively little public attention since it abandoned the manufacture and sale of BASF-branded consumer electronics products in the 1990s. The company began as a dye manufacturer in 1865. Fritz Haber worked with Carl Bosch, one of its employees, to invent the Haber-Bosch, Haber-Bosch process by 1912, after which the company grew rapidly. In 1925, the company merged with ...
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Rio De Janeiro
Rio de Janeiro, or simply Rio, is the capital of the Rio de Janeiro (state), state of Rio de Janeiro. It is the List of cities in Brazil by population, second-most-populous city in Brazil (after São Paulo) and the Largest cities in the Americas, sixth-most-populous city in the Americas. Founded in 1565 by the Portuguese people, Portuguese, the city was initially the seat of the Captaincy of Rio de Janeiro, a domain of the Portuguese Empire. In 1763, it became the capital of the State of Brazil, a List of states of the Portuguese Empire, state of the Portuguese Empire. In 1808, when the Transfer of the Portuguese Court to Brazil, Portuguese Royal Court moved to Brazil, Rio de Janeiro became the seat of the court of Queen Maria I of Portugal. She subsequently, under the leadership of her son the prince regent John VI of Portugal, raised Brazil to the dignity of a kingdom, within the United Kingdom of Portugal, Brazil and the Algarves, United Kingdom of Portugal, Brazil, and Algar ...
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Brazil
Brazil, officially the Federative Republic of Brazil, is the largest country in South America. It is the world's List of countries and dependencies by area, fifth-largest country by area and the List of countries and dependencies by population, seventh-largest by population, with over 212 million people. The country is a federation composed of 26 Federative units of Brazil, states and a Federal District (Brazil), Federal District, which hosts the capital, Brasília. List of cities in Brazil by population, Its most populous city is São Paulo, followed by Rio de Janeiro. Brazil has the most Portuguese-speaking countries, Portuguese speakers in the world and is the only country in the Americas where Portuguese language, Portuguese is an Portuguese-speaking world, official language. Bounded by the Atlantic Ocean on the east, Brazil has a Coastline of Brazil, coastline of . Covering roughly half of South America's land area, it Borders of Brazil, borders all other countries and ter ...
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Guinea Worm
''Dracunculus medinensis'' (Guinea worm, dragon worm, fiery serpent) is a nematode that causes dracunculiasis, also known as Guinea worm disease. The disease is caused by the female which, at around in length, is among the longest nematodes infecting humans. The length of specimens exhibits extreme sexual dimorphism, as the longest recorded male Guinea worm is only . Guinea worm disease is on target to be the second infectious disease of humans to be eradicated, after smallpox, and the ''D. medinensis'' species would be made extinct to accomplish it. It was formerly endemic to a wide swath of Africa and Eurasia; as of 2023, it remains endemic in five countries: Chad, Mali, South Sudan, Angola and Ethiopia, with most cases in Chad. Guinea worm spread to Angola , and it is now considered endemic there. Infection of domestic dogs is a serious complication in Chad. The common name "Guinea worm" is derived from the Guinea region of Western Africa. History ''Dracunculus m ...
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Guinea Worm Eradication
Eradication of dracunculiasis is an ongoing program. Dracunculiasis, or Guinea worm disease, is an infection by the Guinea worm that causes severe pain and open wounds when guinea worms exit the body through the skin. In 1986, there were an estimated 3.5 million cases of Guinea worm in 20 endemic nations in Asia and Africa. The number of human cases has since been reduced by more than 99.999%, to the range of 13–15 per year in 2021–2024, with only six countries remaining to be certified free of transmission: Chad, South Sudan, Mali, Ethiopia, Angola, and Sudan. Of these, only Chad and South Sudan have had human cases reported since the end of 2023. Cameroon has also had some cases in recent years, primarily due to its proximity to Chad, but was previously certified free of internal transmission. The campaign has been spearheaded by the Carter Center and other members of the London Declaration on Neglected Tropical Diseases, with former U.S. president Jimmy Carter as part of ...
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Aedes Aegypti
''Aedes aegypti'' ( or from Greek 'hateful' and from Latin, meaning 'of Egypt'), sometimes called the Egyptian mosquito, dengue mosquito or yellow fever mosquito, is a mosquito that spreads diseases like dengue fever, yellow fever, malaria, and chikungunya. The mosquito can be recognized by black and white markings on its legs and a marking in the form of a lyre on the upper surface of its thorax. This mosquito originated in Africa, but is now a common invasive species that has spread to tropical, subtropical, and temperate regions throughout the world. Biology ''Aedes aegypti'' is a , dark mosquito which can be recognized by white markings on its legs and a marking in the form of a lyre on the upper surface of its thorax. Females are larger than males. Microscopically females possess small palps tipped with silver or white scales, and their antennae have sparse short hairs, whereas those of males are feathery. ''Aedes aegypti'' can be confused with ''Aedes albopic ...
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Standing Water
Water stagnation occurs when water stops Environmental flow, flowing for a long period of time. Stagnant water can be a significant environmental hazard. Dangers Malaria and dengue are among the main dangers of still water, which can become a breeding ground for the mosquitoes that transmit these diseases. Stagnant water can be dangerous because it provides a better incubator than running water for many kinds of infectious pathogens. Stagnant water can be contaminated with human and animal feces, particularly in deserts or other areas of low rainfall. Water stagnation for as little as six days can completely change bacterial community composition and increase cell count. Stagnant water may be classified into the following basic, although overlapping, types: * Water body stagnation (stagnation in swamp, lake, lagoon, river, etc.) * Surface water, Surface and ground water stagnation * Trapped water stagnation. The water may be trapped in human artifacts (discarded cans, plant ...
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Endemic (epidemiology)
In epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly present, or maintained at a baseline level, without extra infections being brought into the group as a result of travel or similar means. The term describes the distribution of an infectious disease among a group of people or within a populated area. An endemic disease always has a steady, predictable number of people getting sick, but that number can be high ('' hyperendemic'') or low (''hypoendemic''), and the disease can be severe or mild. Also, a disease that is usually endemic can become epidemic. For example, chickenpox is endemic in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus '' Anopheles''). Consequently, there is no constant baseline level of malaria inf ...
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