Small Interfering RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules, typically 20–24 (normally 21) base pairs in length, similar to MicroRNA, miRNA, and operating within the RNA interference (RNAi) pathway. It interferes with the gene expression, expression of specific genes with complementary nucleotide sequences by degrading mRNA after Transcription (biology), transcription, preventing translation (biology), translation. Text was copied from this source, which is available under Creative Commons Attribution 4.0 International License It was discovered in 1998, by Andrew Fire at Carnegie Institution for Science in Washington DC and Craig Mello at University of Massachusetts in Worcester. Structure Naturally occurring siRNAs have a well-defined structure that is a short (usually 20 to 24-base pair, bp) double-stranded RNA (dsRNA) with phosphorylation, phosphorylated 5' ends and hydr ...
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