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Secnidazole
Secnidazole (trade names Flagentyl, Sindose, Secnil, Solosec) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported. It has also been tested against ''Atopobium vaginae''. In the United States, secnidazole is FDA approved for the treatment of bacterial vaginosis and trichomoniasis Trichomoniasis (trich) is an infectious disease caused by the parasite ''Trichomonas vaginalis''. About 70% of affected people do not have symptoms when infected. When symptoms occur, they typically begin 5 to 28 days after exposure. Symptoms ca ... in adult women. References Further reading * Nitroimidazole antibiotics Antiprotozoal agents {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitroimidazole
5-Nitroimidazole is an organic compound with the formula O2NC3H2N2H. The nitro group at position 5 on the imidazole ring is the most common positional isomer. The term nitroimidazole also refers to a class of antibiotics that share similar chemical structures. Synthesis Imidazole undergoes a nitration reaction with a mixture of nitric acid and sulfuric acid to give 5-nitroimidazole: :C3H3N2H + HNO3 + H2SO4 → O2NC3H2N2H + H2O Nitroimidazole antibiotics From the chemistry perspective, nitroimidazole antibiotics can be classified according to the location of the nitro functional group. Structures with names 4- and 5-nitroimidazole are equivalent from the perspective of drugs since these tautomers readily interconvert. Drugs of the 5-nitro variety include metronidazole, tinidazole, nimorazole, dimetridazole, pretomanid, ornidazole, megazol, and azanidazole. Drugs based on 2-nitromidazoles include benznidazole. Nitroimidazole antibiotics have been used to combat anaerobic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-infective
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune system. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response. Specific medications used to treat infections include antibiotics, antivirals, antifungals, antiprotozoals, and antihelminthics. Infectious diseases resulted in 9.2 million deaths in 2013 (about 17% of all deaths). The branch of medicine that focuses on infections is referred to as infectious disease. Types Infections are caused by infectious agents ( pathogens) including: * Bacteria (e.g. ''Mycobacterium ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dientamoebiasis
Dientamoebiasis is a medical condition caused by infection with ''Dientamoeba fragilis'', a single-cell parasite that infects the lower gastrointestinal tract of humans. It is an important cause of traveler's diarrhea, chronic abdominal pain, chronic fatigue, and failure to thrive in children. Signs and symptoms The most commonly reported symptoms in conjunction with infection with ''D. fragilis'' include abdominal pain (69%) and diarrhea (61%). Diarrhea may be intermittent and may not be present in all cases. It is often chronic, lasting over two weeks. The degree of symptoms may vary from asymptomatic to severe, and can include weight loss, vomiting, fever, and involvement of other digestive organs. Symptoms may be more severe in children. Additional symptoms reported have included: # Weight loss # Fatigue # Nausea and vomiting # Fever # Urticaria (skin rash) # Pruritus (itchiness) # Biliary infection Cause Genetic diversity As many individuals are asymptomatic carriers of ''D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atopobium Vaginae
''Fannyhessea vaginae'' is a species of bacteria in the family ''Atopobiaceae''. It is a facultative anaerobic, Gram-positive rod-shaped or elliptical coccobacilli found as single elements or in pairs or short chains. It is typically isolated from 80% of women with bacterial vaginosis Bacterial vaginosis (BV) is a disease of the vagina caused by excessive growth of bacteria. Common symptoms include increased vaginal discharge that often smells like fish. The discharge is usually white or gray in color. Burning with urinati ... and it is implicated in treatment failures. Invasive infections such as bacteremia have been reported. References Further reading * * * * External links LPSN* Type strain of ''Atopobium vaginae'' at Bac''Dive'' - the Bacterial Diversity Metadatabase Coriobacteriaceae Bacterial vaginosis Bacteria described in 1999 {{actinobacteria-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacterial Vaginosis
Bacterial vaginosis (BV) is a disease of the vagina caused by excessive growth of bacteria. Common symptoms include increased vaginal discharge that often smells like fish. The discharge is usually white or gray in color. Burning with urination may occur. Itching is uncommon. Occasionally, there may be no symptoms. Having BV approximately doubles the risk of infection by a number of sexually transmitted infections, including HIV/AIDS. It also increases the risk of early delivery among pregnant women. BV is caused by an imbalance of the naturally occurring bacteria in the vagina. There is a change in the most common type of bacteria and a hundred to thousand fold increase in total numbers of bacteria present. Typically, bacteria other than ''Lactobacilli'' become more common. Risk factors include douching, new or multiple sex partners, antibiotics, and using an intrauterine device, among others. However, it is not considered a sexually transmitted infection and, unlike gonorrh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trichomoniasis
Trichomoniasis (trich) is an infectious disease caused by the parasite ''Trichomonas vaginalis''. About 70% of affected people do not have symptoms when infected. When symptoms occur, they typically begin 5 to 28 days after exposure. Symptoms can include itching in the genital area, a bad smelling thin vaginal discharge, burning with urination, and pain with sex. Having trichomoniasis increases the risk of getting HIV/AIDS. It may also cause complications during pregnancy. Trichomoniasis is a sexually transmitted infection (STI) which is most often spread through vaginal, oral, or anal sex. It can also spread through genital touching. People who are infected may spread the disease even when symptoms are not present. Diagnosis is by finding the parasite in the vaginal fluid using a microscope, culturing the vaginal fluid or urine, or testing for the parasite's DNA. If present, other STIs should be tested for. Methods of prevention include not having sex, using condoms, not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitroimidazole Antibiotics
5-Nitroimidazole is an organic compound with the formula O2NC3H2N2H. The nitro group at position 5 on the imidazole ring is the most common positional isomer. The term nitroimidazole also refers to a class of antibiotics that share similar chemical structures. Synthesis Imidazole undergoes a nitration reaction with a mixture of nitric acid and sulfuric acid to give 5-nitroimidazole: :C3H3N2H + HNO3 + H2SO4 → O2NC3H2N2H + H2O Nitroimidazole antibiotics From the chemistry perspective, nitroimidazole antibiotics can be classified according to the location of the nitro functional group. Structures with names 4- and 5-nitroimidazole are equivalent from the perspective of drugs since these tautomers readily interconvert. Drugs of the 5-nitro variety include metronidazole, tinidazole, nimorazole, dimetridazole, pretomanid, ornidazole, megazol, and azanidazole. Drugs based on 2-nitromidazoles include benznidazole. Nitroimidazole antibiotics have been used to combat anaerobic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
