Radiosynthesis
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Radiosynthesis
Radiosynthesis is a fully automated synthesis method in which radioactive compounds are produced. Radiosynthesis is generally carried out by several nuclear interface modules, which are protected by the lead shielding and controlled by a computer semi-automatically. The set-ups of modules are different depending on the type of product and synthesis process. Consequently, the modules should be adapted with the synthesis stages. In some cases, such stages of synthesis are carried out manually in order to optimize the radiochemical yield or due to the incompatibility or lack of module. Module Radiosynthesis modules consist of following constant components: *Reservoir: To store reactants *Pipe : To link all components together *Valve : To manage the flow of liquids * Reactor : To proceed the reaction(s) *Temperature and Radioactivity sensor : To adjust and measure the temperature and radioactivity * Preparative HPLC : To purify the Product There are also some components which a ...
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Fully Automated Synthesis
Automated synthesis or automatic synthesis is a set of techniques that use robotic equipment to perform chemical synthesis in an automated way. Automating processes allows for higher efficiency and product quality although automation technology can be cost-prohibitive and there are concerns regarding overdependence and job displacement. Chemical processes were automated throughout the 19th and 20th centuries, with major developments happening in the previous thirty years, as technology advanced. Tasks that are performed may include: synthesis in variety of different conditions, sample preparation, purification, and extractions. Applications of automated synthesis are found on research and industrial scales in a wide variety of fields including polymers, personal care, and radiosynthesis. Automating Synthesis An automated synthesis is very similar in procedure to performing a manual synthesis. The overseeing chemist decides on a target molecule then formulates the experimental ...
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Radiosynthesis Module
Radiosynthesis is a fully automated synthesis method in which radioactive compounds are produced. Radiosynthesis is generally carried out by several nuclear interface modules, which are protected by the lead shielding and controlled by a computer semi-automatically. The set-ups of modules are different depending on the type of product and synthesis process. Consequently, the modules should be adapted with the synthesis stages. In some cases, such stages of synthesis are carried out manually in order to optimize the radiochemical yield or due to the incompatibility or lack of module. Module Radiosynthesis modules consist of following constant components: *Reservoir: To store reactants *Pipe : To link all components together *Valve : To manage the flow of liquids * Reactor : To proceed the reaction(s) *Temperature and Radioactivity sensor : To adjust and measure the temperature and radioactivity * Preparative HPLC : To purify the Product There are also some components which ...
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Hot Cell
Shielded nuclear radiation containment chambers are commonly referred to as hot cells. The word "hot" refers to radioactivity. Hot cells are used in both the nuclear-energy and the nuclear-medicines industries. They are required to protect individuals from radioactive isotopes by providing a safe containment box in which they can control and manipulate the equipment required. Nuclear industry Hot cells are used to inspect spent nuclear fuel rods and to work with other items which are high-energy gamma ray emitters. For instance, the processing of medical isotopes, having been irradiated in a nuclear reactor or particle accelerator, would be carried out in a hot cell. Hot cells are of nuclear proliferation concern, as they can be used to carry out the chemical steps used to extract plutonium (whether weapons grade or not) from reactor fuel. The cutting of the used fuel, the dissolving of the fuel in hot nitric acid and the first extraction cycle of a nuclear reprocessin ...
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Radio Nuclide Generator
Radio is the technology of signaling and communicating using radio waves. Radio waves are electromagnetic waves of frequency between 30 hertz (Hz) and 300  gigahertz (GHz). They are generated by an electronic device called a transmitter connected to an antenna which radiates the waves, and received by another antenna connected to a radio receiver. Radio is very widely used in modern technology, in radio communication, radar, radio navigation, remote control, remote sensing, and other applications. In radio communication, used in radio and television broadcasting, cell phones, two-way radios, wireless networking, and satellite communication, among numerous other uses, radio waves are used to carry information across space from a transmitter to a receiver, by modulating the radio signal (impressing an information signal on the radio wave by varying some aspect of the wave) in the transmitter. In radar, used to locate and track objects like aircraft, ships, spacecraft ...
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Cyclotron
A cyclotron is a type of particle accelerator invented by Ernest O. Lawrence in 1929–1930 at the University of California, Berkeley, and patented in 1932. Lawrence, Ernest O. ''Method and apparatus for the acceleration of ions'', filed: January 26, 1932, granted: February 20, 1934 A cyclotron accelerates charged particles outwards from the center of a flat cylindrical vacuum chamber along a spiral path. The particles are held to a spiral trajectory by a static magnetic field and accelerated by a rapidly varying electric field. Lawrence was awarded the 1939 Nobel Prize in Physics for this invention. The cyclotron was the first "cyclical" accelerator. The primary accelerators before the development of the cyclotron were electrostatic accelerators, such as the Cockcroft–Walton accelerator and Van de Graaff generator. In these accelerators, particles would cross an accelerating electric field only once. Thus, the energy gained by the particles was limited by the maximum elec ...
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HPLC
High-performance liquid chromatography (HPLC), formerly referred to as high-pressure liquid chromatography, is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, causing different flow rates for the different components and leading to the separation of the components as they flow out of the column. HPLC has been used for manufacturing (''e.g.'', during the production process of pharmaceutical and biological products), legal (''e.g.'', detecting performance enhancement drugs in urine), research (''e.g.'', separating the components of a complex biological sample, or of similar synthetic chemicals from each other), and medical (''e.g.'', detecting vitamin D levels in blood serum) purposes. Chrom ...
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Temperature
Temperature is a physical quantity that expresses quantitatively the perceptions of hotness and coldness. Temperature is measured with a thermometer. Thermometers are calibrated in various temperature scales that historically have relied on various reference points and thermometric substances for definition. The most common scales are the Celsius scale with the unit symbol °C (formerly called ''centigrade''), the Fahrenheit scale (°F), and the Kelvin scale (K), the latter being used predominantly for scientific purposes. The kelvin is one of the seven base units in the International System of Units (SI). Absolute zero, i.e., zero kelvin or −273.15 °C, is the lowest point in the thermodynamic temperature scale. Experimentally, it can be approached very closely but not actually reached, as recognized in the third law of thermodynamics. It would be impossible to extract energy as heat from a body at that temperature. Temperature is important in all fields of natur ...
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Survey Meter
Survey meters in radiation protection are hand-held ionising radiation measurement instruments used to check such as personnel, equipment and the environment for radioactive contamination and ambient radiation. The hand-held survey meter is probably the most familiar radiation measuring device owing to its wide and visible use. Types The most commonly used hand-held survey meters are the scintillation counter, which is used in the measurement of alpha, beta and neutron particles; the Geiger counter, widely used for the measurement of alpha, beta and gamma levels; and the ion chamber, which is used for beta, gamma and X-ray measurements. Functional design The instruments are designed to be hand-held, are battery powered and of low mass to allow easy manipulation. Other features include an easily readable display, in counts or radiation dose, and an audible indication of the count rate. This is usually the “click” associated with the Geiger type instrument, and can also be an ...
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Thermometer
A thermometer is a device that temperature measurement, measures temperature or a temperature gradient (the degree of hotness or coldness of an object). A thermometer has two important elements: (1) a temperature sensor (e.g. the bulb of a mercury-in-glass thermometer or the pyrometric sensor in an infrared thermometer) in which some change occurs with a change in temperature; and (2) some means of converting this change into a numerical value (e.g. the visible scale that is marked on a mercury-in-glass thermometer or the digital readout on an infrared model). Thermometers are widely used in technology and industry to monitor processes, in meteorology, in medicine, and in scientific research. History While an individual thermometer is able to measure degrees of hotness, the readings on two thermometers cannot be compared unless they conform to an agreed scale. Today there is an absolute thermodynamic temperature scale. Internationally agreed temperature scales are designed to ...
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Valve
A valve is a device or natural object that regulates, directs or controls the flow of a fluid (gases, liquids, fluidized solids, or slurries) by opening, closing, or partially obstructing various passageways. Valves are technically fittings, but are usually discussed as a separate category. In an open valve, fluid flows in a direction from higher pressure to lower pressure. The word is derived from the Latin ''valva'', the moving part of a door, in turn from ''volvere'', to turn, roll. The simplest, and very ancient, valve is simply a freely hinged flap which swings down to obstruct fluid (gas or liquid) flow in one direction, but is pushed up by the flow itself when the flow is moving in the opposite direction. This is called a check valve, as it prevents or "checks" the flow in one direction. Modern control valves may regulate pressure or flow downstream and operate on sophisticated automation systems. Valves have many uses, including controlling water for irrigation, ...
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Chemical Reactor
A chemical reactor is an enclosed volume in which a chemical reaction takes place. In chemical engineering, it is generally understood to be a process vessel used to carry out a chemical reaction, which is one of the classic unit operations in chemical process analysis. The design of a chemical reactor deals with multiple aspects of chemical engineering. Chemical engineers design reactors to maximize net present value for the given reaction. Designers ensure that the reaction proceeds with the highest efficiency towards the desired output product, producing the highest yield of product while requiring the least amount of money to purchase and operate. Normal operating expenses include energy input, energy removal, raw material costs, labor, etc. Energy changes can come in the form of heating or cooling, pumping to increase pressure, frictional pressure loss or agitation.Chemical reaction engineering is the branch of chemical engineering which deals with chemical reactors and their d ...
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Pipe (fluid Conveyance)
A pipe is a tubular section or hollow cylinder, usually but not necessarily of circular cross-section, used mainly to convey substances which can flow — liquids and gases (fluids), slurries, powders and masses of small solids. It can also be used for structural applications; hollow pipe is far stiffer per unit weight than solid members. In common usage the words ''pipe'' and ''tube'' are usually interchangeable, but in industry and engineering, the terms are uniquely defined. Depending on the applicable standard to which it is manufactured, pipe is generally specified by a nominal diameter with a constant outside diameter (OD) and a schedule that defines the thickness. Tube is most often specified by the OD and wall thickness, but may be specified by any two of OD, inside diameter (ID), and wall thickness. Pipe is generally manufactured to one of several international and national industrial standards. While similar standards exist for specific industry applicati ...
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