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Retroperitoneal Space
The retroperitoneal space (retroperitoneum) is the anatomical space (sometimes a potential space) behind (''retro'') the peritoneum. It has no specific delineating anatomical structures. Organs are retroperitoneal if they have peritoneum on their anterior side only. Structures that are not suspended by mesentery in the abdominal cavity and that lie between the parietal peritoneum and abdominal wall are classified as retroperitoneal. This is different from organs that are not retroperitoneal, which have peritoneum on their posterior side and are suspended by mesentery in the abdominal cavity. The retroperitoneum can be further subdivided into the following: *Perirenal (or perinephric) space *Anterior pararenal (or paranephric) space *Posterior pararenal (or paranephric) space Retroperitoneal structures Structures that lie behind the peritoneum are termed "retroperitoneal". Organs that were once suspended within the abdominal cavity by mesentery but migrated posterior to the p ...
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Horizontal Plane
In astronomy, geography, and related sciences and contexts, a '' direction'' or ''plane'' passing by a given point is said to be vertical if it contains the local gravity direction at that point. Conversely, a direction or plane is said to be horizontal if it is perpendicular to the vertical direction. In general, something that is vertical can be drawn from up to down (or down to up), such as the y-axis in the Cartesian coordinate system. Historical definition The word ''horizontal'' is derived from the Latin , which derives from the Greek , meaning 'separating' or 'marking a boundary'. The word ''vertical'' is derived from the late Latin ', which is from the same root as ''vertex'', meaning 'highest point' or more literally the 'turning point' such as in a whirlpool. Girard Desargues defined the vertical to be perpendicular to the horizon in his 1636 book ''Perspective''. Geophysical definition The plumb line and spirit level In physics, engineering and construction, th ...
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Renal Fascia
The renal fascia is a layer of connective tissue encapsulating the kidneys and the adrenal glands. It can be divided into: *The anterior renal fascia, also called Gerota's fascia (after Dimitrie Gerota) *The posterior renal fascia, also called Zuckerkandl's fascia or fascia retrorenalis The renal fascia separates the adipose capsule of kidney from the overlying pararenal fat. The deeper layers below the renal fascia are, in order, the adipose capsule (or perirenal fat), the renal capsule and finally the parenchyma of the renal cortex. The spaces about the kidney are typically divided into three compartments: the perinephric space and the anterior and posterior pararenal spaces. Anterior renal fascia * Medial attachment: Passes anterior to the kidney, renal vessels, abdominal aorta and inferior vena cava and fuses with the anterior layer of the renal fascia of the opposite kidney. * Lateral attachment: Fuses with the psoas fascia and side of the body of the vertebrae. * Superior at ...
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Sarcoma
A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal (connective tissue) origin. Connective tissue is a broad term that includes bone, cartilage, fat, vascular, or hematopoietic tissues, and sarcomas can arise in any of these types of tissues. As a result, there are many subtypes of sarcoma, which are classified based on the specific tissue and type of cell from which the tumor originates. Sarcomas are ''primary'' connective tissue tumors, meaning that they arise in connective tissues. This is in contrast to ''secondary'' (or "metastatic") connective tissue tumors, which occur when a cancer from elsewhere in the body (such as the lungs, breast tissue or prostate) spreads to the connective tissue. The word ''sarcoma'' is derived from the Greek σάρκωμα ''sarkōma'' "fleshy excrescence or substance", itself from σάρξ ''sarx'' meaning "flesh". Classification Sarcomas are typically divided into two major groups: bone sarcom ...
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Metastasis
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues. Cancer occurs after cells are genetically altered to proliferate rapidly and indefinitely. This uncontrolled proliferation by mitosis produces a primary heterogeneic tumour. The cells which constitute the tumor eventually undergo metaplasia, followed by dysplasia then anaplasia, resulting in a malignant phenotype. This malignancy allows for invasion into the circulation, followed by invasion to a second site for tumorigenesis. Some cancer cells known as circulating tumor cells acquire the ability to penetrate the walls of lymphatic or blood vessels, after which they are abl ...
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ...
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Retroperitoneal Lymph Node Dissection
Retroperitoneal lymph node dissection (RPLND) is a surgical procedure to remove abdominal lymph nodes. It is used to treat testicular cancer, as well as to help establish the exact stage and type of the cancer. Indications Testicular cancer metastasizes in a predictable pattern, and lymph nodes in the retroperitoneum are typically the first place it lands. By examining the removed lymphatic tissue, a pathologist can determine whether the disease has spread. If no malignant tissue is found, the cancer can be labeled Stage I, limited to the testicle. The procedure is common in the treatment of Stage I and II non-seminomatous germ cell tumors. In seminomas, another form of testicular cancer, radiation therapy is generally preferred to the invasive RPLND procedure. Whether RPLND is needed after orchiectomy depends on the type of tumor and its stage. RPLND may be performed to remove tumor remnants that persist after chemotherapy, because these remnants might otherwise spread and b ...
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Retroperitoneal Fibrosis
Retroperitoneal fibrosis or Ormond's disease is a disease featuring the proliferation of fibrous tissue in the retroperitoneum, the compartment of the body containing the kidneys, aorta, renal tract, and various other structures. It may present with lower back pain, kidney failure, hypertension, deep vein thrombosis, and other obstructive symptoms. It is named after John Kelso Ormond, who rediscovered the condition in 1948. Causes The association of idiopathic retroperitoneal fibrosis with various immune-related conditions and response to immunosuppression led to a search for an autoimmune cause of idiopathic RPF. Many of these previously idiopathic cases can now be attributed to IgG4-related disease, an autoimmune disorder proposed in 2003. Otherwise, one-third of cases are secondary to malignancy, medication (methysergide, hydralazine, beta blockers), prior radiotherapy, or certain infections. Other associations include: * connective tissue disease * Riedel's thyroiditis * sc ...
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Retroperitoneal Hemorrhage
Retroperitoneal bleeding is an accumulation of blood in the retroperitoneal space. Signs and symptoms may include abdominal or upper leg pain, hematuria, and shock. It can be caused by major trauma or by non-traumatic mechanisms. Signs and symptoms Signs and symptoms may include: * abdominal pain. * upper leg pain. * hematuria. * shock. Causes Retroperitoneal bleeds are most often caused by major trauma, such as from a traffic collisions or a fall. Less common non-traumatic causes including: * anticoagulation. * a ruptured aortic aneurysm. * a ruptured renal aneurysm. * acute pancreatitis. * malignancy. Retroperitoneal bleeds may also be iatrogenic, caused accidentally during medical procedures. Such procedures include cannulating the femoral artery for cardiac catheterization or for interventional radiology, and the administration of a psoas compartment nerve block. Diagnosis Neurology As well as initial symptoms, the accumulation of blood in the retroperitoneal space ...
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Duodenum
The duodenum is the first section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum. In mammals the duodenum may be the principal site for iron absorption. The duodenum precedes the jejunum and ileum and is the shortest part of the small intestine. In humans, the duodenum is a hollow jointed tube about 25–38 cm (10–15 inches) long connecting the stomach to the middle part of the small intestine. It begins with the duodenal bulb and ends at the suspensory muscle of duodenum. Duodenum can be divided into four parts: the first (superior), the second (descending), the third (horizontal) and the fourth (ascending) parts. Structure The duodenum is a C-shaped structure lying adjacent to the stomach. It is divided anatomically into four sections. The first part of the duodenum lies ...
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Pancreas
The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine gland, i.e. it has both an endocrine and a digestive exocrine function. 99% of the pancreas is exocrine and 1% is endocrine. As an endocrine gland, it functions mostly to regulate blood sugar levels, secreting the hormones insulin, glucagon, somatostatin, and pancreatic polypeptide. As a part of the digestive system, it functions as an exocrine gland secreting pancreatic juice into the duodenum through the pancreatic duct. This juice contains bicarbonate, which neutralizes acid entering the duodenum from the stomach; and digestive enzymes, which break down carbohydrates, proteins, and fats in food entering the duodenum from the stomach. Inflammation of the pancreas is known as pancreatitis, with common causes including chronic alcohol use and gallstones. Becaus ...
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Renal Capsule
The renal capsule is a tough fibrous layer surrounding the kidney and covered in a layer of perirenal fat known as the adipose capsule of kidney. The adipose capsule is sometimes included in the structure of the renal capsule. It provides some protection from trauma and damage. The renal capsule is surrounded by the renal fascia. Overlying the renal fascia and between this and the transverse fascia is a region of pararenal fat. Structure The renal capsule surrounds the functional tissue of the kidney, and is itself surrounded by a fatty adipose capsule, fascia, and fat. From the inner part of the kidney to outside the kidney, the positioning of the capsule is: # renal medulla # renal cortex # renal capsule # adipose capsule of kidney (or perirenal fat, or perinephric fat) # renal fascia # pararenal fat # peritoneum (anteriorly), and transverse fascia (posteriorly). Sometimes the adipose capsule of the kidney also known as the perirenal fat, is regarded as a part of the renal ...
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Perirenal Fat
The retroperitoneal space (retroperitoneum) is the anatomical space (sometimes a potential space) behind (''retro'') the peritoneum. It has no specific delineating anatomical structures. Organs are retroperitoneal if they have peritoneum on their anterior side only. Structures that are not suspended by mesentery in the abdominal cavity and that lie between the parietal peritoneum and abdominal wall are classified as retroperitoneal. This is different from organs that are not retroperitoneal, which have peritoneum on their posterior side and are suspended by mesentery in the abdominal cavity. The retroperitoneum can be further subdivided into the following: *Perirenal (or perinephric) space *Anterior pararenal (or paranephric) space *Posterior pararenal (or paranephric) space Retroperitoneal structures Structures that lie behind the peritoneum are termed "retroperitoneal". Organs that were once suspended within the abdominal cavity by mesentery but migrated posterior to the p ...
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