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Prospective Cohort Study
A prospective cohort study is a longitudinal cohort study that follows over time a group of similar individuals (cohorts) who differ with respect to certain factors under study, to determine how these factors affect rates of a certain outcome. For example, one might follow a cohort of middle-aged truck drivers who vary in terms of smoking habits, to test the hypothesis that the 20-year incidence rate of lung cancer will be highest among heavy smokers, followed by moderate smokers, and then nonsmokers. The prospective study is important for research on the etiology of diseases and disorders. The distinguishing feature of a prospective cohort study is that at the time that the investigators begin enrolling subjects and collecting baseline exposure information, none of the subjects have developed any of the outcomes of interest. After baseline information is collected, subjects in a prospective cohort study are then followed "longitudinally," i.e. over a period of time, usually for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
STrengthening The Reporting Of OBservational Studies In Epidemiology
The STROBE ''(STrengthening the Reporting of OBservational studies in Epidemiology)'' Statement is a reporting guideline including a checklist of 22 items that are considered essential for good reporting of observational studies. It was published simultaneously in several leading biomedical journals in October and November 2007 and comprises both the checklist and an explanation and elaboration article which gives examples of good reporting and provides authors with more guidance on good reporting. It is also referred to in the Uniform Requirements for Manuscripts Submitted to Biomedical Journals established by the International Committee of Medical Journal Editors and is endorsed by hundreds of biomedical journals. Purpose ''The STROBE Statement was developed by the STROBE Initiative, an international collaboration of epidemiologists, methodologists, statisticians, researchers and journal editors with the aim to assist authors when writing up analytical observational studies, to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Therapeutic Effect
Therapeutic effect refers to the response(s) after a treatment of any kind, the results of which are judged to be useful or favorable. This is true whether the result was expected, unexpected, or even an unintended consequence. An adverse effect (including nocebo) is the converse and refers to harmful or undesired response(s). What constitutes a therapeutic effect versus a side effect is a matter of both the nature of the situation and the goals of treatment. No inherent difference separates therapeutic and undesired side effects; both responses are behavioral/physiologic changes that occur as a response to the treatment strategy or agent. Treatment scope To maximize therapeutic effects (desired) and minimize side effects (undesired) requires recognition and quantification of the treatment in multiple dimensions. In the specific case of targeted pharmaceutical interventions, a combination of therapies is often needed to achieve the desired results. Pharmacology examples *A 201 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blinded Experiment
In a blind or blinded experiment, information which may influence the participants of the experiment is withheld until after the experiment is complete. Good blinding can reduce or eliminate experimental biases that arise from a participants' expectations, observer's effect on the participants, observer bias, confirmation bias, and other sources. A blind can be imposed on any participant of an experiment, including subjects, researchers, technicians, data analysts, and evaluators. In some cases, while blinding would be useful, it is impossible or unethical. For example, it is not possible to blind a patient to their treatment in a physical therapy intervention. A good clinical protocol ensures that blinding is as effective as possible within ethical and practical constraints. During the course of an experiment, a participant becomes unblinded if they deduce or otherwise obtain information that has been masked to them. For example, a patient who experiences a side effect may corr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rotterdam Study
The Rotterdam Study or ERGO ( Dutch: ''Erasmus Rotterdam Gezondheid Onderzoek'') is a prospective, population-based cohort study. The aim of the Rotterdam Study is to investigate etiology, preclinical phase, prognosis and potential intervention targets of chronic diseases in mid- and late-life. The study focuses on several diseases, such as cardiovascular, neurological, ophthalmological, hepatic, endocrine, dermatological, otolaryngological, respiratory, locomotor and psychiatric diseases. History Researchers of the department of Epidemiology & Biostatistics at the Erasmus Medical Center led by Professor Albert Hofman, conceptualized the study in the mid-1980s as response to increase in the proportion of elderly persons in the population who are also living with chronic diseases. The study was established in 1990 in the Ommoord district of Rotterdam, The Netherlands. On March 26, 1991, Princess Juliana opened the ERGO research center at Briandplaats, Rotterdam. Cohort ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Million Women Study
The Million Women Study is a study of women’s health analysing data from more than one million women aged 50 and over, led by Dame Valerie Beral and a team of researchers at the Cancer Epidemiology Unit, University of Oxford. It is a collaborative project between Cancer Research UK and the National Health Service (NHS), with additional funding from the Medical Research Council (UK). One key focus of the study relates to the effects of hormone replacement therapy use on women's health. The study has confirmed the findings in the Women's Health Initiative (WHI) that women currently using HRT are more likely to develop breast cancer than those who are not using HRT. Results from the Million Women Study, together with those of the WHI trial from the USA, have influenced national policy, including recent recommendations on the prescribing and use of hormone replacement therapy from the Royal College of Obstetricians and Gynaecologists and from the Commission on Human Medicines. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Framingham Heart Study
The Framingham Heart Study is a long-term, ongoing cardiovascular cohort study of residents of the city of Framingham, Massachusetts. The study began in 1948 with 5,209 adult subjects from Framingham, and is now on its third generation of participants. Prior to the study almost nothing was known about the epidemiology of hypertensive or arteriosclerotic cardiovascular disease. Much of the now-common knowledge concerning heart disease, such as the effects of diet, exercise, and common medications such as aspirin, is based on this longitudinal study. It is a project of the National Heart, Lung, and Blood Institute, in collaboration with (since 1971) Boston University. Various health professionals from the hospitals and universities of Greater Boston staff the project. History In 1948, the study was commissioned by Congress, with a choice made between Framingham, Massachusetts and Paintsville, Kentucky. Framingham was chosen when residents showed more general interest in heart rese ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caerphilly Heart Disease Study
The Caerphilly Heart Disease Study, also known as the Caerphilly Prospective Study (CaPS), is an epidemiological prospective cohort, set up in 1979 in a representative population sample drawn from Caerphilly, a typical small town in South Wales, UK. The initial aim was to examine relationships between a wide range of social, lifestyle, dietary and other factors with incident vascular disease. Opportunity was also taken, in collaboration with a range of clinical and laboratory colleagues, to collect data on a wide range of factors with possible relevance to diseases other than vascular, and at the same time to collect clinical information on incident disease events. The study was initiated by Professor Peter Elwood OBE, Director of the Medical Research Council (MRC) Epidemiology Unit for South Wales. The work has so far led to over 400 publications in the medical press. History In 1948, an MRC epidemiological unit was set up in Cardiff, South Wales, under Professor Archie Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miquel Porta
Miquel Porta (Barcelona, 1957) is a Catalan physician, epidemiologist and scholar. He has promoted the integration of biological, clinical and environmental knowledge and methods in health research and teaching, which he has conducted internationally; notably, in Spain, at the University of North Carolina at Chapel Hill, Harvard, Imperial College London, and several other universities in Europe, North America, Kuwait, and Brazil. Appointed by the International Epidemiological Association (IE in 2008 he succeeded the Canadian epidemiologist John M. Last as Editor of "A Dictionary of Epidemiology". In the Preface to this book he argues for an inclusive and integrative practice of the science of epidemiology. He is currently the head of the Clinical and Molecular Epidemiology of Cancer Unit at the Hospital del Mar Institute of Medical Research - IMI He is also a Professor of Preventive Medicine & Public Health, School of Medicine, Universitat Autònoma de Barcelona (UAB), an Adjunct P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Longitudinal Study
A longitudinal study (or longitudinal survey, or panel study) is a research design that involves repeated observations of the same variables (e.g., people) over short or long periods of time (i.e., uses longitudinal data). It is often a type of observational study, although it can also be structured as longitudinal randomized experiment. Longitudinal studies are often used in social-personality and clinical psychology, to study rapid fluctuations in behaviors, thoughts, and emotions from moment to moment or day to day; in developmental psychology, to study developmental trends across the life span; and in sociology, to study life events throughout lifetimes or generations; and in consumer research and political polling to study consumer trends. The reason for this is that, unlike cross-sectional studies, in which different individuals with the same characteristics are compared, longitudinal studies track the same people, and so the differences observed in those people are less like ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Answers
Answer commonly refers to response to a question. Answer may also refer to: * Answer (law), any reply to a question, counter-statement or defense in a legal procedure Music * Answer, an element of a fugue Albums * ''Answer'' (Angela Aki album), 2009 * ''Answer'' (Supercar album), 2004 * ''Answers'' (album), 1994 * ''The Answers'', an album by Blue October Songs * "Answer" (Tohoshinki song) * "Answer" (Flow song), 2007 *"Answer", by Tyler, the Creator from the album ''Wolf'' *"Answer", by Sarah McLachlan from her 2003 album ''Afterglow'' *"Answer", by Mayu Maeshima, opening song from the 2021 anime ''Full Dive'' Publications * ''Answers'' (periodical), British weekly paper founded in 1888, initially titled ''Answers to Correspondents'' *''Answer'', a very short science-fiction story published in 1954 by Fredric Brown. *''Answers'', an American magazine published by Answers in Genesis * ''The Questionnaire'' (Salomon novel), also published as "The Answers" Groups, organiza ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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