|
Pre-locus Coeruleus
Pre-locus coeruleus is a small nucleus in the brainstem. This small cluster of neurons also is referred to by the abbreviation "pre-LC". It was named "pre-LC" because it lies just Anatomical terms of location#Cranial and caudal, rostral to (in front of) the locus coeruleus, which is commonly abbreviated "LC". Definition The pre-locus coeruleus was first formally defined during the course of neuroanatomical tract-tracing and c-Fos experiments aimed at uncovering the connections and functions of aldosterone-sensitive HSD2 neurons in the nucleus of the solitary tract. First, HSD2 neurons were found to innervate the pre-LC, as evidenced by (1) dense labeling with an anterograde axonal tracer in pre-LC after that tracer had been injected into the nucleus of the solitary tract and (2) the complementary finding of retrograde labeling of HSD2 neurons after injection of a retrograde tracer into the pre-LC. Further, experimental conditions which activate the HSD2 neurons simultaneously activa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FoxP2+TH Sagittal
FOX (forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, Cellular differentiation, differentiation, and longevity. Many FOX proteins are important to embryonic development. FOX proteins also have pioneer factor, pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes. The defining feature of FOX proteins is the fork head domain, forkhead box, a sequence of 80 to 100 amino acids forming a DNA motif, motif that binds to DNA. This forkhead motif is also known as the Winged-helix transcription factors, winged helix, due to the butterfly-like appearance of the loops in the protein structure of the domain. Forkhead proteins are a subgroup of the helix-turn-helix class of proteins. Biological roles Many genes encoding FOX proteins have been identified. For example, the FOXF2 gene encodes forkhead box F2, one of many hum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |