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Polysome
A polyribosome (or polysome or ergosome) is a group of ribosomes bound to an mRNA molecule like “beads” on a “thread”. It consists of a complex of an mRNA molecule and two or more ribosomes that act to translate mRNA instructions into polypeptide Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. ...s. Originally coined "ergosomes" in 1963, they were further characterized by Jonathan Warner, Paul M. Knopf, and Alex Rich. Polysomes are formed during the elongation phase when ribosomes and elongation factors synthesize the encoded polypeptide. Multiple ribosomes move along the coding region of mRNA, creating a polysome. The ability of multiple ribosomes to function on an mRNA molecule explains the limited abundance of mRNA in the cell. Polyribosome structure differs between pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alex Rich
Alexander Rich (15 November 1924 – 27 April 2015) was an American biologist and biophysicist. He was the William Thompson Sedgwick Professor of Biophysics at MIT (since 1958) and Harvard Medical School. Rich earned an A.B. ('' magna cum laude'') and an M.D. ('' cum laude'') from Harvard University. He was a post-doc of Linus Pauling along with James Watson. During this time he was a member of the RNA Tie Club, a social and discussion group which attacked the question of how DNA encodes proteins. He had over 600 publications to his name. Born in Hartford, Connecticut, Rich was the founder of Alkermes and was a director beginning in 1987. Dr. Rich was co-chairman of the board of directors of Repligen Corporation, a biopharmaceutical company. He also served on the editorial board of '' Genomics'' and the ''Journal of Biomolecular Structure and Dynamics''. Personal life Rich spent his early life in Springfield, Massachusetts. He grew up in a working-class family and work ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |