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Periamygdaloid Cortex
Periamygdaloid cortex (or periamygdalar area) is a portion of the rhinencephalon consisting of paleocortex. It is a cortical-like nucleus of the amygdaloid complex. Though considered a nucleus, the periamygdalar area is more commonly associated with cortex due to its layered structure and location on the outer surface of the brain. The periamygdaloid cortex is located on the dorsal surface of the brain bordered by the piriform cortex, entorhinal cortex, perirhinal cortex, periamygdalar claustrum, and anterior amygdaloid area. Its ventromedial and dorsolateral borders are defined by the first myelin bundle of the external capsule, while its remaining borders show no myelinated fiber projections or inputs as well as a higher density of acetylcholinesterase and cholinergic synapses than the neighboring anterior amygdaloid area. The periamygdaloid cortex plays a role in olfaction, and recent studies have shown that it may be involved in many more processes including Opioid use disorder ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhinencephalon
In animal anatomy, the rhinencephalon (from the Greek, ῥίς, ''rhis'' = "nose", and ἐγκέφαλος, ''enkephalos'' = "brain"), also called the smell-brain or olfactory brain, is a part of the brain involved with smell (i.e. olfaction). It forms the paleocortex and is rudimentary in the human brain. Components The term ''rhinencephalon'' has been used to describe different structures at different points in time. One definition includes the olfactory bulb, olfactory tract, anterior olfactory nucleus, anterior perforated substance, medial olfactory stria, lateral olfactory stria, parts of the amygdala and prepyriform area. Some references classify other areas of the brain related to perception of smell as rhinencephalon, but areas of the human brain that receive fibers strictly from the olfactory bulb are limited to those of the paleopallium. As such, the rhinencephalon includes the olfactory bulb, the olfactory tract, the olfactory tubercle and striae, the anterior olf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Depressive Disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, the term was adopted by the American Psychiatric Association for this symptom cluster under mood disorders in the 1980 version of the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM-III), and has become widely used since. The diagnosis of major depressive disorder is based on the person's reported experiences, behavior reported by relatives or friends, and a mental status examination. There is no laboratory test for the disorder, but testing may be done to rule out physical conditions that can cause similar symptoms. The most common time of onset is in a person's 20s, with females affected about twice as often as males. The course of the disorder varies widely, from one epis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Negative Affectivity
Negative affectivity (NA), or negative affect, is a personality variable that involves the experience of negative emotions and poor self-concept. Negative affectivity subsumes a variety of negative emotions, including anger, contempt, disgust, guilt, fear, and nervousness. Low negative affectivity is characterized by frequent states of calmness and serenity, along with states of confidence, activeness, and great enthusiasm. Individuals differ in negative emotional reactivity.Tellegen, A. (1985). Structures of mood and personality and their relevance to assessing anxiety, with an emphasis on self-report. In A. H. Tuma & J. D. Maser (Eds.), Anxiety and the Anxiety disorders, (pp. 681-706), Hilssdale, NJ: Erlbaum. Trait negative affectivity roughly corresponds to the dominant personality factor of anxiety/neuroticism that is found within the Big Five personality traits as emotional stability. The Big Five are characterized as openness, conscientiousness, extraversion, agreeableness, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prodynorphin
Prodynorphin, also known as proenkephalin B, is an opioid polypeptide hormone involved with chemical signal transduction and cell communication. The gene for prodynorphin is expressed in the endometrium and the striatum, and its gene map locus is 20pter-p12. Prodynorphin is a basic building-block of endorphins, the chemical messengers in the brain that appear most heavily involved in the anticipation and experience of pain and the formation of deep emotional bonds, and that are also critical in learning and memory. The gene is thought to influence perception, as well as susceptibility to drug dependence, and is expressed more readily in human beings than in other primates. Evolutionary implications Most humans have multiple copies of the regulatory gene sequence for prodynorphin, which is virtually identical among all primates, whereas other primates have only a single copy. In addition, most Asian populations have two copies of the gene sequence for prodynorphin, whereas East Afric ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lateral Olfactory Stria
The olfactory tract is a bilateral bundle of afferent nerve fibers from the mitral and tufted cells of the olfactory bulb that connects to several target regions in the brain, including the piriform cortex, amygdala, and entorhinal cortex. It is a narrow white band, triangular on coronal section, the apex being directed upward. Structure The olfactory tract and olfactory bulb lie in the olfactory sulcus a sulcus formed by the medial orbital gyrus on the inferior surface of each frontal lobe. The olfactory tracts lie in the sulci which run closely parallel to the midline. Fibers of the olfactory tract appear to end in the antero-lateral part of the olfactory tubercle, the dorsal and external parts of the anterior olfactory nucleus, the frontal and temporal parts of the prepyriform area, the cortico-medial group of amygdala nuclei and the nucleus of the stria terminalis. The olfactory tract divides posteriorly into a medial and a lateral stria. Caudal to this is the olfactory ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Olfactory Bulb
The olfactory bulb (Latin: ''bulbus olfactorius'') is a grey matter, neural structure of the vertebrate forebrain involved in olfaction, the sense of odor, smell. It sends olfactory information to be further processed in the amygdala, the orbitofrontal cortex (OFC) and the hippocampus where it plays a role in emotion, memory and learning. The bulb is divided into two distinct structures: the main olfactory bulb and the accessory olfactory bulb. The main olfactory bulb connects to the amygdala via the piriform cortex of the primary olfactory cortex and directly projects from the main olfactory bulb to specific amygdala areas. The accessory olfactory bulb resides on the dorsal-posterior region of the main olfactory bulb and forms a parallel pathway. Destruction of the olfactory bulb results in ipsilateral anosmia, while irritative lesions of the uncus can result in olfactory and gustatory hallucinations. Structure In most vertebrates, the olfactory bulb is the most Anatomical term ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Primary Olfactory Cortex
The primary olfactory cortex (POC) is a portion of the cerebral cortex. It is found in the inferior part of the temporal lobe of the brain. It receives input from the olfactory tract. It is involved in the sense of smell (olfaction). Structure The primary olfactory cortex is in the inferior part of the temporal lobe of the brain. It involves the anterior olfactory nucleus, the piriform cortex, the olfactory tubercle, part of the amygdala, part of the entorhinal cortex, and the periamygdaloid cortex. Some sources state that it also includes the prepyriform area. The primary olfactory cortex receives fibres from the olfactory tract. It receives input from mitral cells and tufted cells. These cells do not pass through the thalamus. The primary olfactory cortex then sends fibres to the hippocampus, thalamus, and the hypothalamus. Function The primary olfactory cortex is involved in the sense of smell The sense of smell, or olfaction, is the special sense through which smel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yawn
A yawn is a reflex lasting 4-7 seconds, and is characterized by a long inspiratory phase with gradual mouth gaping, followed by a brief climax (or acme) with muscle stretching, and a rapid expiratory phase with muscle relaxation. For fish and birds, this is described as gradual mouth gaping, staying open for at least 3 seconds and subsequently a rapid closure of the mouth. Almost all vertebrate animals, including mammals, birds, reptiles, amphibians, and even fish, experience yawning. The study of yawning is called chasmology. Yawning (oscitation) most often occurs in adults immediately before and after sleep, during tedious activities and as a result of its contagious quality. It is commonly associated with tiredness, stress, sleepiness, boredom, or even hunger. In humans, yawning is often triggered by the perception that others are yawning (for example, seeing a person yawning, or talking to someone on the phone who is yawning). This is a typical example of positive feedb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opioid Use Disorder
Opioid use disorder (OUD) is a substance use disorder characterized by cravings for opioids, continued use despite physical and/or psychological deterioration, increased tolerance with use, and withdrawal symptoms after discontinuing opioids. Opioid withdrawal symptoms include nausea, muscle aches, diarrhea, trouble sleeping, agitation, and a low mood. Addiction and dependence are important components of OUD. Risk factors for OUD include a history of opioid misuse, current opioid misuse, young age, socioeconomic status, race, untreated psychiatric disorders, and environments that promote misuse (social, family, professional, etc.). Complications may include opioid overdose, suicide, HIV/AIDS, hepatitis C, and problems meeting social or professional responsibilities. Diagnosis may be based on criteria by the American Psychiatric Association in the DSM-5. If more than two of 11 criteria are present during a year, the diagnosis is said to be present. Opioids include substances suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paleocortex
In anatomy of animals, the paleocortex, or paleopallium, is a region within the telencephalon in the vertebrate brain. This type of cortical tissue consists of three cortical laminae (layers of neuronal cell bodies). In comparison, the neocortex has six layers and the archicortex has three or four layers. Because the number of laminae that compose a type of cortical tissue seems to be directly proportional to both the information-processing capabilities of that tissue and its phylogenetic age, paleocortex is thought to be an intermediate between the archicortex (or archipallium) and the neocortex (or neopallium) in both aspects. The paleocortex (or paleopallium) and the archicortex (or the archipallium) of the cerebral cortex together constitute the mammalian allocortex or the heterogenetic cortex. The distinction for what is called neocortex or isocortex, which comprises most of the human brain (about 90%), is made from the number of cellular layers that the structure comprises ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Olfaction
The sense of smell, or olfaction, is the special sense through which smells (or odors) are perceived. The sense of smell has many functions, including detecting desirable foods, hazards, and pheromones, and plays a role in taste. In humans, it occurs when an odor binds to a receptor within the nasal cavity, transmitting a signal through the olfactory system. Glomeruli aggregate signals from these receptors and transmit them to the olfactory bulb, where the sensory input will start to interact with parts of the brain responsible for smell identification, memory, and emotion. There are many different causes for alteration, lack, or disturbance to a normal sense of smell, and can include damage to the nose or smell receptors, or central problems affecting the brain. Some causes include upper respiratory infections, traumatic brain injury, and neurodegenerative disease. History of study Early scientific study of the sense of smell includes the extensive doctoral dissertation of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholinesterase
Acetylcholinesterase (HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ... that catalysis, catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters: : acetylcholine + H2O = choline + acetate It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate neurotransmission, synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. Enzyme structure and mechani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
