Phytophotodermatitis
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Phytophotodermatitis
Phytophotodermatitis, also known as berloque dermatitis or margarita photodermatitis, is a cutaneous phototoxic inflammatory reaction resulting from contact with a light-sensitizing botanical agent followed by exposure to ultraviolet light (from the sun, for instance). Symptoms include erythema, edema, blisters (Skin condition#Vesicle, vesicles and/or Skin condition#Bulla, bullae), and delayed hyperpigmentation. Heat and moisture tend to exacerbate the reaction. A reaction may be elicited in any person who has been exposed to adequate amounts of both a photosensitizing, photosensitizer and ultraviolet light. Phytophotodermatitis is not an Immunology, immunologic response; no prior exposure to the photosensitizing agent is required. The photosensitizing substances found in phototoxic plants belong to a class of chemical compounds called the furanocoumarins, which are activated by long-wavelength ultraviolet (UVA) light. The most toxic of these organic compounds are the linear furan ...
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Bergapten
Bergapten (5-methoxypsoralen) is a naturally-occurring organic chemical compound produced by numerous plant species, especially from the carrot family Apiaceae and the citrus family Rutaceae. For example, bergapten has been extracted from 24 species of the genus '' Heracleum'' in the family Apiaceae. Cited by Mitchell and Rook (1979). In the family Rutaceae, various ''Citrus'' species contain significant amounts of bergapten, especially the bergamot orange, the micrantha, and certain varieties of lime and bitter orange. Bergapten belongs to a class of chemical compounds known as the furanocoumarins. In 1834, Kalbrunner isolated 5-methoxypsoralen from bergamot essential oil, hence the common name "bergapten". It was the first furanocoumarin to be isolated and identified. Toxicity Bergapten is a derivative of psoralen, the parent compound of a family of naturally-occurring organic compounds known as the linear furanocoumarins (so called since they exhibit a linear chemical ...
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Apiaceae
Apiaceae or Umbelliferae is a family of mostly aromatic flowering plants named after the type genus ''Apium'' and commonly known as the celery, carrot or parsley family, or simply as umbellifers. It is the 16th-largest family of flowering plants, with more than 3,700 species in 434 generaStevens, P.F. (2001 onwards)Angiosperm Phylogeny Website Version 9, June 2008. including such well-known and economically important plants as ajwain, angelica, anise, asafoetida, caraway, carrot, celery, chervil, coriander, cumin, dill, fennel, lovage, cow parsley, parsley, parsnip and sea holly, as well as silphium, a plant whose identity is unclear and which may be extinct. The family Apiaceae includes a significant number of phototoxic species, such as giant hogweed, and a smaller number of highly poisonous species, such as poison hemlock, water hemlock, spotted cowbane, fool's parsley, and various species of water dropwort. Description Most Apiaceae are annual, biennial or perennial ...
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Furanocoumarin
The furanocoumarins, or furocoumarins, are a class of organic chemical compounds produced by a variety of plants. Most of the plant species found to contain furanocoumarins belong to a handful of plant families. The families Apiaceae and Rutaceae include the largest numbers of plant species that contain furanocoumarins. The families Moraceae and Fabaceae include a few widely distributed plant species that contain furanocoumarins. Generally furanocoumarins are most abundant in plants that have flowered and in ripe seeds and fruits. (An exception is the common fig where furanocoumarins are found chiefly in the milky sap of the leaves and shoots but not the fruits. Cited in McGovern and Barkley 2000, section&nbsPhytophotodermatitis) During the early stages of plant growth, their presence is not easily detected. Structure The chemical structure of furanocoumarins consists of a furan ring fused with a coumarin. The furan ring may be fused in various ways producing several differen ...
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Phototoxic
Phototoxicity, also called photoirritation, is a chemically induced skin irritation, requiring light, that does not involve the immune system. It is a type of photosensitivity. The skin response resembles an exaggerated sunburn. The involved chemical may enter into the skin by topical administration or it may reach the skin via systemic circulation following ingestion or parenteral administration. The chemical needs to be "photoactive," which means that when it absorbs light, the absorbed energy produces molecular changes that cause toxicity. Many synthetic compounds, including drug substances like tetracyclines or fluoroquinolones, are known to cause these effects. Surface contact with some such chemicals causes photodermatitis; many plants cause phytophotodermatitis. Light-induced toxicity is a common phenomenon in Photosensitivity in humans, humans; however, it also occurs in other animals. Scientific background A phototoxic substance is a chemical compound which becomes toxic ...
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Heracleum Persicum
''Heracleum persicum'', commonly known as Persian hogweed or by its native name ''Golpar'' ( fa, گلپر) is a species of Heracleum (plant), hogweed, a perennial herbaceous plant in the carrot family Apiaceae. It grows wild in humid mountainous regions in Iran and some adjacent areas. Having been introduced in the 1830s, it has spread across Scandinavia. It is now very common in northern Norway, where one of its names is Tromsø palm. The plant has also been spotted in Sweden. In Finland, it has been declared as invasive species. Persian hogweed is a polycarpic perennial, that is, a mature plant flowers and bears fruit season after season. Invasiveness status In Europe, Persian hogweed is included since 2016 in the list of Invasive Alien Species of Union concern (the Union list). This implies that this species cannot be imported, cultivated, transported, commercialized, planted, or intentionally released into the environment in the whole of the European Union. Uses Food u ...
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Heracleum (plant)
''Heracleum'' is a genus of biennial and perennial herbs in the carrot family Apiaceae. They are found throughout the temperate northern hemisphere and in high mountains as far south as Ethiopia. Common names for the genus or its species include hogweed and cow parsnip. The genus name ''Heracleum'' was described by Carl Linnaeus in 1753. It derives from the Ancient Greek () "of Heracles", referring to the mythological hero. Species Many species of the genus ''Heracleum'' are similar in appearance. An outlier is ''H. mantegazzianum'', the large size of which is exceptional. Common species include: * ''Heracleum mantegazzianum'', giant hogweed, native to the western Caucasus region of Eurasia, a serious invasive species in many areas of Europe and North America * ''Heracleum sosnowskyi'', Sosnowsky's hogweed, native to the eastern Caucasus, a common weed throughout Europe and Asia * ''Heracleum persicum'', Persian hogweed, native to Iran, Iraq, and Turkey * ''Heracleum spho ...
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Parsnip
The parsnip (''Pastinaca sativa'') is a root vegetable closely related to carrot and parsley, all belonging to the flowering plant family Apiaceae. It is a biennial plant usually grown as an annual. Its long taproot has cream-colored skin and flesh, and, left in the ground to mature, it becomes sweeter in flavor after winter frosts. In its first growing season, the plant has a rosette of pinnate, mid-green leaves. If unharvested, in its second growing season it produces a flowering stem topped by an umbel of small yellow flowers, later producing pale brown, flat, winged seeds. By this time, the stem has become woody and the tap root inedible. The parsnip is native to Eurasia; it has been used as a vegetable since antiquity and was cultivated by the Romans, although some confusion exists between parsnips and carrots in the literature of the time. It was used as a sweetener before the arrival of cane sugar in Europe. Parsnips are usually cooked, but can also be eaten raw. T ...
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Ammi Majus
''Ammi majus'', commonly called bishop's flower, false bishop's weed, laceflower, bullwort, etc., is a member of the carrot family Apiaceae. The plant, which has white lace-like flower clusters, has a large distribution through Southern Europe, North Africa and West and Central Asia, though it is hypothesized to be native to the Nile River Valley. Nomenclature The plant is called by various common names: bishop's flower or bishop's weed (false bishop's weed); laceflower, lady's lace or false Queen Anne's lace; bullwort (large bullwort); white dill and greater ammi. It is known in Arabic as ''hirz al-shayateen'' () or ''khella/khilla shaitani'' (). The plant is also introduced into China, where it is called ''da a min qin'' ( zh, 大阿米芹) and cultivated in medicinal farms. Description ''Ammi majus'' is a herbaceous annual, or rather a biennial that behaves like an annual in cultivation. The lower leaves are 1-2-pinnate, upper leaves 2(-3)-pinnate with serrate lobes. Th ...
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Rutaceae
The Rutaceae is a family, commonly known as the rueRUTACEAE
in BoDD – Botanical Dermatology Database
or family, of s, usually placed in the order . Species of the family generally have s that divide into four or five parts, usually w ...
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Moraceae
The Moraceae — often called the mulberry family or fig family — are a family of flowering plants comprising about 38 genera and over 1100 species. Most are widespread in tropical and subtropical regions, less so in temperate climates; however, their distribution is cosmopolitan overall. The only synapomorphy within the Moraceae is presence of laticifers and milky sap in all parenchymatous tissues, but generally useful field characters include two carpels sometimes with one reduced, compound inconspicuous flowers, and compound fruits. The family includes well-known plants such as the fig, banyan, breadfruit, jackfruit, mulberry, and Osage orange. The 'flowers' of Moraceae are often pseudanthia (reduced inflorescences). Historical taxonomy Formerly included within the now defunct order Urticales, recent molecular studies have resulted in the family's placement within the Rosales in a clade called the urticalean rosids that also includes Ulmaceae, Celtidaceae, Cannabaceae, ...
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Fabaceae
The Fabaceae or Leguminosae,International Code of Nomenclature for algae, fungi, and plants.
Article 18.5 states: "The following names, of long usage, are treated as validly published: ....Leguminosae (nom. alt.: Fabaceae; type: Faba Mill. Vicia L.; ... When the Papilionaceae are regarded as a family distinct from the remainder of the Leguminosae, the name Papilionaceae is conserved against Leguminosae." English pronunciations are as follows: , and .
commonly known as the legume, pea, or bean family, are a large and agriculturally important of

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Cutaneous
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Other animal coverings, such as the arthropod exoskeleton, have different developmental origin, structure and chemical composition. The adjective cutaneous means "of the skin" (from Latin ''cutis'' 'skin'). In mammals, the skin is an organ of the integumentary system made up of multiple layers of ectodermal tissue and guards the underlying muscles, bones, ligaments, and internal organs. Skin of a different nature exists in amphibians, reptiles, and birds. Skin (including cutaneous and subcutaneous tissues) plays crucial roles in formation, structure, and function of extraskeletal apparatus such as horns of bovids (e.g., cattle) and rhinos, cervids' antlers, giraffids' ossicones, armadillos' osteoderm, and os penis/os clitoris. All mammals have some hair on their skin, even marine mammals like whales, dolphins, a ...
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