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Oneirogen
An oneirogen, from the Greek ὄνειρος ''óneiros'' meaning "dream" and ''gen'' "to create", is that which produces or enhances dreamlike states of consciousness. This is characterized by an immersive dream state similar to REM sleep, which can range from realistic to alien or abstract. Many dream-enhancing plants such as dream herb ('' Calea zacatechichi'') and African dream herb (''Entada rheedii''), as well as the hallucinogenic diviner's sage ('' Salvia divinorum''), have been used for thousands of years in a form of divination through dreams, called oneiromancy, in which practitioners seek to receive psychic or prophetic information during dream states. The term ''oneirogen'' commonly describes a wide array of psychoactive plants and chemicals ranging from normal dream enhancers to intense dissociative or deliriant drugs. Effects experienced with the use of oneirogens may include microsleep, hypnagogia, fugue states, rapid eye movement sleep (REM), hypnic jerks, lucid dre ...
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Calea Zacatechichi
''Calea ternifolia'' ( syn. ''Calea zacatechichi'') is a species of flowering plant in the aster family, Asteraceae. It is native to Mexico and Central America. Its English language common names include bitter-grass, Mexican calea, and dream herb.Simonienko, K., et al. (2013)Psychoactive plant species – actual list of plants prohibited in Poland.''Psychiatria Polska'' XLVII(3), 499–508. It is used in traditional medicine and ritual in its native range.Ferraz, A., et al. (2009)Pharmacological and genotoxic evaluation of ''Calea clematidea'' and ''Calea uniflora''.''Latin American Journal of Pharmacy'' 28(6), 858-6/ref> Uses In Mexico the plant is used as an herbalism, herbal remedy for dysentery and fever. The Zoque Popoluca people call the plant ''tam huñi'' ("bitter gum") and use it to treat diarrhea and asthma, and the Mixe people know it as ''poop taam ujts'' ("white bitter herb") and use it for stomachache and fever. The Chontal people of Oaxaca reportedly use th ...
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Atropa Belladonna
''Atropa belladonna'', commonly known as belladonna or deadly nightshade, is a toxic perennial herbaceous plant in the nightshade family Solanaceae, which also includes tomatoes, potatoes, and eggplant (aubergine). It is native to Europe, North Africa, and Western Asia. Its distribution extends from Great Britain in the west to western Ukraine and the Iranian province of Gilan in the east. It is also naturalised or introduced in some parts of Canada and the United States. The foliage and berries are extremely toxic when ingested, containing tropane alkaloids. These toxins include atropine, scopolamine, and hyoscyamine, which cause delirium and hallucinations, and are also used as pharmaceutical anticholinergics. Tropane alkaloids are of common occurrence not only in the Old World tribes Hyoscyameae (to which the genus Atropa belongs) and Mandragoreae, but also in the New World tribe Datureae - all of which belong to the subfamily Solanoideae of the plant family Solanaceae. ...
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Muscimol
Muscimol (also known as agarin or pantherine) is one of the principal psychoactive constituents of ''Amanita muscaria'' and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABAA receptors and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity. This colorless or white solid is classified as an isoxazole. Muscimol went under clinical trial phase I for epilepsy, but the trial was discontinued. Biochemistry Muscimol is one of the psychoactive compounds responsible for the effects of ''Amanita muscaria'' intoxication. Ibotenic acid, a neurotoxic secondary metabolite of ''Amanita muscaria'', serves as a prodrug to muscimol when the mushroom is ingested or dried, converting to muscimol via decarboxylation. Muscimol is produced in the mushrooms ''Amanita muscaria'' (fly agaric) and ''Amanita pantherina'', along with muscarine (which is present in trace amounts and it is not active), muscazone, and ibotenic acid. ''A ...
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Benzatropine
Benzatropine (INN), known as benztropine in the United States and Japan, is a medication used to treat movement disorders like parkinsonism and dystonia, as well as extrapyramidal side effects of antipsychotics, including akathisia. It is not useful for tardive dyskinesia. It is taken by mouth or by injection into a vein or muscle. Benefits are seen within two hours and last for up to ten hours. Common side effects include dry mouth, blurry vision, nausea, and constipation. Serious side effect may include urinary retention, hallucinations, hyperthermia, and poor coordination. It is unclear if use during pregnancy or breastfeeding is safe. Benzatropine is an anticholinergic which works by blocking the activity of the muscarinic acetylcholine receptor. Benzatropine was approved for medical use in the United States in 1954. It is available as a generic medication. In 2020, it was the 229th most commonly prescribed medication in the United States, with more than 2million prescript ...
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Artemisia Vulgaris
''Artemisia vulgaris'', the common mugwort, is a species of flowering plant in the daisy family Asteraceae. It is one of several species in the genus ''Artemisia'' commonly known as mugwort, although ''Artemisia vulgaris'' is the species most often called mugwort. It is also occasionally known as riverside wormwood, felon herb, chrysanthemum weed, wild wormwood, old Uncle Henry, sailor's tobacco, naughty man, old man, or St. John's plant (not to be confused with St John's wort). Mugworts have been used medicinally and as culinary herbs. Distribution ''A. vulgaris'' is native to temperate Europe, Asia, North Africa, and Alaska, and is naturalized in North America, where some consider it an invasive weed. It is a very common plant growing on nitrogenous soils, such as waste places, roadsides and other weedy and uncultivated areas. Uses Traditionally, it has been used as one of the flavoring and bittering agents of gruit ales, a type of unhopped, fermented grain beverage. In Vi ...
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Amanita Muscaria
''Amanita muscaria'', commonly known as the fly agaric or fly amanita, is a basidiomycete of the genus ''Amanita''. It is also a muscimol mushroom. Native throughout the temperate and boreal regions of the Northern Hemisphere, ''Amanita muscaria'' has been unintentionally introduced to many countries in the Southern Hemisphere, generally as a symbiont with pine and birch plantations, and is now a true cosmopolitan species. It associates with various deciduous and coniferous trees. Arguably the most iconic toadstool species, the fly agaric is a large white- gilled, white-spotted, usually red mushroom, and is one of the most recognizable and widely encountered in popular culture, including in video games—e.g., the extensive use of a recognizable ''Amanita muscaria'' in the Mario franchise and its Super Mushroom power-up—and television—e.g., the houses in The Smurfs franchise. Despite its easily distinguishable features, ''Amanita muscaria'' is a fungus with several know ...
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Atropine
Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. It is typically given intravenously or by injection into a muscle. Eye drops are also available which are used to treat uveitis and early amblyopia. The intravenous solution usually begins working within a minute and lasts half an hour to an hour. Large doses may be required to treat some poisonings. Common side effects include a dry mouth, large pupils, urinary retention, constipation, and a fast heart rate. It should generally not be used in people with angle closure glaucoma. While there is no evidence that its use during pregnancy causes birth defects, that has not been well studied. It is likely safe during breastfeeding. It is an antimuscarinic (a type of anticholinergic) that works by inhibiting the parasympathetic nervous system. Atropine occurs n ...
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Datura
''Datura'' is a genus of nine species of highly poisonous, vespertine-flowering plants belonging to the nightshade family Solanaceae. They are commonly known as thornapples or jimsonweeds, but are also known as devil's trumpets (not to be confused with angel's trumpets, which are placed in the closely related genus ''Brugmansia''). Other English common names include moonflower, devil's weed, and hell's bells. All species of ''Datura'' are extremely poisonous and potentially psychoactive, especially their seeds and flowers, which can cause respiratory depression, arrhythmias, fever, delirium, hallucinations, anticholinergic syndrome, psychosis, and even death if taken internally. Due to their effects and symptoms, they have occasionally been used not only as poisons, but also as hallucinogens by various groups throughout history. Traditionally, psychoactive administration of ''Datura'' species has often been associated with witchcraft and sorcery or similar practices in man ...
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Oneiromancy
Oneiromancy (from the , and ) is a form of divination based upon dreams, and also uses dreams to predict the future. Oneirogen plants may also be used to produce or enhance dream-like states of consciousness. Occasionally, the dreamer feels as if they are transported to another time or place, and this is offered as evidence they are in fact providing divine information upon their return. Biblical oneiromancy Dreams occur throughout the Bible as omens or messages from God; * God speaks to Abram while he is in a deep sleep (Genesis 15); * God speaks to Abimelech, the king of Gerar, concerning his intentions regarding Sarah, Abraham's wife (Genesis 20); * Jacob dreams of a ladder to heaven (Genesis 28); * his son Joseph dreamed of his future success (Genesis 37), interpreted the dreams of Pharaoh of Egypt's cupbearer and baker while imprisoned (Genesis 40) and interpreted the dreams of the Pharaoh of Egypt (Genesis 41); * Solomon conversed with God in his dreams (1 Kings 3); * Dani ...
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Salvia Divinorum
''Salvia divinorum'' (Latin: "sage of the diviners"; also called ska maría pastora, seer's sage, yerba de la pastora, magic mint or simply salvia) is a plant species with transient psychoactive properties when its leaves are consumed by chewing, smoking, or as a tea. The leaves contain opioid-like compounds that induce hallucinations. Because the plant has not been well-studied in high-quality clinical research, little is known about its toxicology, adverse effects, or safety over long-term consumption. Its native habitat is cloud forest in the isolated Sierra Mazateca of Oaxaca, Mexico, where it grows in shady, moist locations. Valdes 1987, p. 106. The plant grows to over a meter high, has hollow square stems like others in the mint family Lamiaceae, large leaves, and occasional white flowers with violet calyxes. Botanists have not determined whether ''Salvia divinorum'' is a cultigen or a hybrid because native plants reproduce vegetatively and rarely produce viable seed. ...
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Entada Rheedii
''Entada rheedii'', commonly known as African dream herb or snuff box sea bean, and as the cacoon vine in Jamaica, is a large woody liana or climber of the Mimosa Family (Mimosaceae). The vine can grow as long as 120 meters (393.7 feet). Their seeds have a thick and durable seed coat which allows them to survive lengthy periods of immersion in seawater. Naming Though its scientific name was first published as ''E. rheedii'', it is often written as ''Entada rheedei'', honouring Hendrik Adriaan van Rheede tot Draakestein (1637–1691).The International Plant Names Index (2004)''Entada rheedei'' Accessed 5 September 2007. Subspecies The following subspecies have been used: * '' Entada rheedii rheedii'' * '' Entada rheedii sinohimalensis'' (Grierson & D.G.Long) Panigrahi Traditional use The species is employed in African traditional medicine to induce vivid dreams, enabling communication with the spirit world. The inner meat of the seed would be either consumed directly, or the me ...
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Dextromethorphan
Dextromethorphan (DXM) is a medication most often used as a cough suppressant in over-the-counter cold and cough medicines. It is sold in syrup, tablet, spray, and lozenge forms. In 2022, the FDA approved a formulation of it combined with bupropion named Auvelity to serve as a rapid acting antidepressant in patients with major depressive disorder. It is in the morphinan class of medications with sedative, dissociative, and stimulant properties (at lower doses). Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors. In its pure form, dextromethorphan occurs as a white powder. Dextromethorphan is also used recreationally. When exceeding approved dosages, dextromethorphan acts as a dissociative hallucinogen. It has multiple mechanisms of action, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonis ...
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