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Noninvasive Follicular Thyroid Neoplasm With Papillary-like Nuclear Features
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, and may be over-treated if classified as a type of cancer. Signs and symptoms The clinical presentation of the patients is identical to other thyroid tumors, where there is usually a painless, asymptomatic, mobile thyroid gland nodule or enlargement. Depending on the size, additional symptoms of hoarseness, difficulty swallowing, or other compression symptoms may be experienced. In nearly all cases, the patients do not have any thyroid hormone dysfunction (hyperthyroidism or hypothyroidism – respectively, excessive or low hormone levels). Genetics This tumor shows a very high association with other follicular-pattern tumors, with RAS mutations ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Papillary Thyroid Carcinoma
Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer, representing 75 percent to 85 percent of all thyroid cancer cases.Chapter 20 in: 8th edition. It occurs more frequently in women and presents in the 20–55 year age group. It is also the predominant cancer type in children with thyroid cancer, and in patients with thyroid cancer who have had previous radiation to the head and neck. It is often well-cellular differentiation, differentiated, slow-growing, and localized, although it can metastasis, metastasize. Diagnosis Papillary thyroid carcinoma is usually discovered on routine examination as an asymptomatic thyroid nodule that appears as a neck mass. In some instances, the mass may have produced local symptoms. This mass is normally referred to a Needle aspiration biopsy, fine needle aspiration biopsy (FNA) for investigation. FNA accuracy is very high and it is a process widely used in these cases. Other investigation methods inclu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyroid Gland
The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans it is in the neck and consists of two connected lobe (anatomy), lobes. The lower two thirds of the lobes are connected by a thin band of Connective tissue, tissue called the thyroid isthmus. The thyroid is located at the front of the neck, below the Adam's apple. Microscopically, the functional unit of the thyroid gland is the spherical Thyroid follicular cell#Location, thyroid follicle, lined with thyroid follicular cell, follicular cells (thyrocytes), and occasional parafollicular cells that surround a follicular lumen, lumen containing colloid. The thyroid gland secretes three hormones: the two thyroid hormonestriiodothyronine, triiodothyronine (T3) and thyroid hormone, thyroxine (T4)and a peptide hormone, calcitonin. The thyroid hormones influence the basal metabolic rate, metabolic rate and protein biosynthesis, protein synthesis, and in children, growth and development. Calcitonin plays a role in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radioactive Iodine
There are 37 known isotopes of iodine (53I) from 108I to 144I; all undergo radioactive decay except 127I, which is stable. Iodine is thus a monoisotopic element. Its longest-lived radioactive isotope, 129I, has a half-life of 15.7 million years, which is far too short for it to exist as a primordial nuclide. Cosmogenic sources of 129I produce very tiny quantities of it that are too small to affect atomic weight measurements; iodine is thus also a mononuclidic element—one that is found in nature only as a single nuclide. Most 129I derived radioactivity on Earth is man-made, an unwanted long-lived byproduct of early nuclear tests and nuclear fission accidents. All other iodine radioisotopes have half-lives less than 60 days, and four of these are used as tracers and therapeutic agents in medicine. These are 123I, 124I, 125I, and 131I. All industrial production of radioactive iodine isotopes involves these four useful radionuclides. The isotope 135I has a half-life less than se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyroidectomy
A thyroidectomy is an operation that involves the surgical removal of all or part of the thyroid gland. In general surgery, endocrine or head and neck surgeons often perform a thyroidectomy when a patient has thyroid cancer or some other condition of the thyroid gland (such as hyperthyroidism) or goiter. Other indications for surgery include cosmetic (very enlarged thyroid), or symptomatic obstruction (causing difficulties in swallowing or breathing). Thyroidectomy is a common surgical procedure that has several potential complications or sequelae including: temporary or permanent change in voice, temporary or permanently low calcium, need for lifelong thyroid hormone replacement, bleeding, infection, and the remote possibility of airway obstruction due to bilateral vocal cord paralysis. Complications are uncommon when the procedure is performed by an experienced surgeon. The thyroid produces several hormones, such as thyroxine (T4), triiodothyronine (T3), and calcitonin. After ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lobectomy
Lobectomy means ''surgical excision of a lobe''. This may refer to a lobe of the lung (also simply called a lobectomy), a lobe of the thyroid (hemithyroidectomy), a lobe of the brain (as in anterior temporal lobectomy), or a lobe of the liver (hepatectomy). __TOC__ Lung lobectomy A lobectomy of the lung is performed in early-stage non-small cell lung cancer patients. It is not performed on patients that have lung cancer that has spread to other parts of the body. Tumor size, type, and location are major factors as to whether a lobectomy is performed. This can be due to cancer or smoking. Lung lobectomies are performed on patients as young as eleven or twelve who have no cancer or smoking history, but have conditions from birth or early childhood that necessitate the operation. Such patients will have reduced lung capacity which tends to limit their range of activities through life. They often need to use inhalers on a daily basis, and are often classified as being asthma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitoses
In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is maintained. Therefore, mitosis is also known as equational division. In general, mitosis is preceded by S phase of interphase (during which DNA replication occurs) and is often followed by telophase and cytokinesis; which divides the cytoplasm, organelles and cell membrane of one cell into two new cells containing roughly equal shares of these cellular components. The different stages of mitosis altogether define the mitotic (M) phase of an animal cell cycle—the division of the mother cell into two daughter cells genetically identical to each other. The process of mitosis is divided into stages corresponding to the completion of one set of activities and the start of the next. These stages are preprophase (specific to plant cells), prophase, p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Necrosis
Necrosis () is a form of cell injury which results in the premature death of cells in living tissue by autolysis. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated digestion of cell components. In contrast, apoptosis is a naturally occurring programmed and targeted cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal. Cellular death due to necrosis does not follow the apoptotic signal transduction pathway, but rather various receptors are activated and result in the loss of cell membrane integrity and an uncontrolled release of products of cell death into the extracellular space. This initiates in the surrounding tissue an inflammatory response, which attracts leukocytes and nearby phagocytes which eliminate the dead cells by phagocytosis. However, microbial damaging substances released by leukocytes would crea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psammoma Bodies
A psammoma body is a round collection of calcium, seen microscopically. The term is derived from the Greek word ψάμμος (''psámmos''), meaning "sand". Cause Psammoma bodies are associated with the papillary (nipple-like) histo morphology and are thought to arise from, # Infarction and calcification of papillae tips. # Calcification of intralymphatic tumor thrombi. Association with lesions Psammoma bodies are commonly seen in certain tumors such as: * Papillary thyroid carcinoma * Papillary renal cell carcinoma * Ovarian papillary serous cystadenoma and cystadenocarcinoma * Endometrial adenocarcinomas (Papillary serous carcinoma ~3%-4%) * Meningiomas, in the central nervous system * Peritoneal and Pleural Mesothelioma * Somatostatinoma (pancreas) * Prolactinoma of the pituitary * Glucagonoma * Micropapillary subtype of Lung Adenocarcinoma Benign lesions Psammoma bodies may be seen in: * Endosalpingiosis Endosalpingiosis is a condition in which fallopian tube-like ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromatin
Chromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division, preventing DNA damage, and regulating gene expression and DNA replication. During mitosis and meiosis, chromatin facilitates proper segregation of the chromosomes in anaphase; the characteristic shapes of chromosomes visible during this stage are the result of DNA being coiled into highly condensed chromatin. The primary protein components of chromatin are histones. An octamer of two sets of four histone cores (Histone H2A, Histone H2B, Histone H3, and Histone H4) bind to DNA and function as "anchors" around which the strands are wound.Maeshima, K., Ide, S., & Babokhov, M. (2019). Dynamic chromatin organization without the 30-nm fiber. ''Current opinion in cell biology, 58,'' 95–104. https://doi.o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Membrane
The nuclear envelope, also known as the nuclear membrane, is made up of two lipid bilayer membranes that in eukaryotic cells surround the nucleus, which encloses the genetic material. The nuclear envelope consists of two lipid bilayer membranes: an inner nuclear membrane and an outer nuclear membrane. The space between the membranes is called the perinuclear space. It is usually about 10–50 nm wide. The outer nuclear membrane is continuous with the endoplasmic reticulum membrane. The nuclear envelope has many nuclear pores that allow materials to move between the cytosol and the nucleus. Intermediate filament proteins called lamins form a structure called the nuclear lamina on the inner aspect of the inner nuclear membrane and give structural support to the nucleus. Structure The nuclear envelope is made up of two lipid bilayer membranes, an inner nuclear membrane and an outer nuclear membrane. These membranes are connected to each other by nuclear pores. Two sets of in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Size
The rms charge radius is a measure of the size of an atomic nucleus, particularly the proton distribution. It can be measured by the scattering of electrons by the nucleus. Relative changes in the mean squared nuclear charge distribution can be precisely measured with atomic spectroscopy. Definition The problem of defining a radius for the atomic nucleus has some similarity to that of defining a radius for the entire atom; neither have well defined boundaries. However, basic liquid drop models of the nucleus imagine a fairly uniform density of nucleons, theoretically giving a more recognizable surface to a nucleus than an atom, the latter being composed of highly diffuse electron clouds with density gradually reducing away from the centre. For individual protons and neutrons or small nuclei, the concepts of size and boundary can be less clear. A single nucleon needs to be regarded as a " color confined" bag of three valence quarks, binding gluons and so called "sea" of quark-an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyroid NIFTP Nuclear Features Of Enlarged Nuclei Showing Optical Clearing
The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans it is in the neck and consists of two connected lobes. The lower two thirds of the lobes are connected by a thin band of tissue called the thyroid isthmus. The thyroid is located at the front of the neck, below the Adam's apple. Microscopically, the functional unit of the thyroid gland is the spherical thyroid follicle, lined with follicular cells (thyrocytes), and occasional parafollicular cells that surround a lumen containing colloid. The thyroid gland secretes three hormones: the two thyroid hormones triiodothyronine (T3) and thyroxine (T4)and a peptide hormone, calcitonin. The thyroid hormones influence the metabolic rate and protein synthesis, and in children, growth and development. Calcitonin plays a role in calcium homeostasis. Secretion of the two thyroid hormones is regulated by thyroid-stimulating hormone (TSH), which is secreted from the anterior pituitary gland. TSH is regulated by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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