Neuroprotectin
Neuroprotectin D1 (NPD1) (10''R'',17''S''-dihydroxy-4''Z'',7''Z'',11''E'',13''E'',15''Z'',19''Z''-docosahexaenoic acid) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA. Like other members of the specialized proresolving mediators class of PUFA metabolites, NPD1 exerts potent anti-inflammatory and anti-apoptotic/neuroprotective bioactivity. Other neuroprotectins with similar activity include: PDX (10''R'',17''S''-dihydroxy-4''Z'',7''Z'',11''E'',13''Z'',15''E'',19''Z''-docosahexaenoic acid); 20-hydroxy-PD1 (10''R'',17''S'',20-trihydroxy-4''Z'',7''Z'',11''E'',13''E'',15''Z'',19''Z''-docosahexaenoic acid); and 10-epi-PD1 (10''R'',17''S''-Dihydroxy-4''Z'',7''Z'',11''E'',13''E'',15''Z'',19''Z''-docosahexaenoic acid). The activity of neuroprotectin-like metabolite, 17-epi-PD1 (10''R'',17''R''-dihydroxy-4''Z'',7''Z'',11''E'',13''E'',15''Z'',1 ...
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Protectin D1
Protectin D1 also known as neuroprotectin D1 (when it acts in the nervous system) and abbreviated most commonly as PD1 or NPD1 is a member of the class of specialized proresolving mediators. Like other members of this class of polyunsaturated fatty acid metabolites, it possesses strong anti-inflammatory, anti-apoptotic and neuroprotective activity. PD1 is an aliphatic acyclic alkene 22 carbons in length with two hydroxyl groups at the 10 and 17 carbon positions and one carboxylic acid group at the one carbon position. Specifically, PD1 is an endogenous stereoselective lipid mediator classified as an autocoid protectin. Autacoids are enzymatically derived chemical mediators with distinct biological activities and molecular structures. Protectins are signaling molecules that are produced enzymatically from unsaturated fatty acids. Their molecular structure is characterized by the presence of a conjugated system of double bonds. PD1, like other protectins, is produced by the oxygena ...
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