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Natural Genetic Engineering
Natural genetic engineering (NGE) is a class of process proposed by molecular biologist James A. Shapiro to account for novelty created in the course of biological evolution. Shapiro developed this work in several peer-reviewed publications from 1992 onwards, and later in his 2011 book ''Evolution: A View from the 21st Century'', which has been updated with a second edition in 2022. He uses NGE to account for several proposed counterexamples to the central dogma of molecular biology (Francis Crick's proposal of 1957 that the direction of the flow of sequence information is only from nucleic acid to proteins, and never the reverse). Shapiro drew from work as diverse as the adaptivity of the mammalian immune system, ciliate macronuclei and epigenetics. The work gained some measure of notoriety after being championed by proponents of Intelligent Design, despite Shapiro's explicit repudiation of that movement. Concept Shapiro first laid out his ideas of natural genetic engineering in 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James A
James is a common English language surname and given name: *James (name), the typically masculine first name James * James (surname), various people with the last name James James or James City may also refer to: People * King James (other), various kings named James * Saint James (other) * James (musician) * James, brother of Jesus Places Canada * James Bay, a large body of water * James, Ontario United Kingdom * James College, a college of the University of York United States * James, Georgia, an unincorporated community * James, Iowa, an unincorporated community * James City, North Carolina * James City County, Virginia ** James City (Virginia Company) ** James City Shire * James City, Pennsylvania * St. James City, Florida Arts, entertainment, and media * ''James'' (2005 film), a Bollywood film * ''James'' (2008 film), an Irish short film * ''James'' (2022 film), an Indian Kannada-language film * James the Red Engine, a character in ''Thomas the Tank En ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modern Synthesis (20th Century)
The modern synthesis was the early 20th-century synthesis of Charles Darwin's theory of evolution and Gregor Mendel's ideas on heredity into a joint mathematical framework. Julian Huxley coined the term in his 1942 book, ''Evolution: The Modern Synthesis''. The synthesis combined the ideas of natural selection, Mendelian inheritance, Mendelian genetics, and population genetics. It also related the broad-scale macroevolution seen by paleontology, palaeontologists to the small-scale microevolution of local population, populations. The synthesis was defined differently by its founders, with Ernst Mayr in 1959, G. Ledyard Stebbins in 1966, and Theodosius Dobzhansky in 1974 offering differing basic postulates, though they all include natural selection, working on heritable variation supplied by mutation. Other major figures in the synthesis included E. B. Ford, Bernhard Rensch, Ivan Schmalhausen, and George Gaylord Simpson. An early event in the modern synthesis was R. A. Fisher's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolution News And Views
The Center for Science and Culture (CSC), formerly known as the Center for the Renewal of Science and Culture (CRSC), is part of the Discovery Institute (DI), a conservative Christian think tank A think tank, or policy institute, is a research institute that performs research and advocacy concerning topics such as social policy, political strategy, economics, military, technology, and culture. Most think tanks are non-governmenta ... in the United States. The CSC lobbies for the inclusion of creationism in the form of intelligent design (ID) in state school#United States, public-school science curricula as an explanation for the origins of life and the universe while trying to cast doubt on the scientific theory, theory of evolution. These positions have been rejected by the scientific community, which identifies intelligent design as pseudoscience, pseudoscientific neo-creationism, whereas the theory of evolution is overwhelmingly accepted as a matter of scientific co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytosine Deaminase
In enzymology, a cytosine deaminase () is an enzyme that catalyzes the chemical reaction :cytosine + H2O \rightleftharpoons uracil + NH3 Thus, the two substrates of this enzyme are cytosine and H2O, whereas its two products are uracil and NH3. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytosine aminohydrolase. This enzyme is also called isocytosine deaminase. This enzyme participates in pyrimidine metabolism. Structural studies As of late 2007, 13 structures A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ... have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , and . References * * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytosine Methylation
DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including genomic imprinting, X-chromosome inactivation, repression of transposable elements, aging, and carcinogenesis. As of 2016, two nucleobases have been found on which natural, enzymatic DNA methylation takes place: adenine and cytosine. The modified bases are N6-methyladenineD. B. Dunn, J. D. Smith: ''The occurrence of 6-methylaminopurine in deoxyribonucleic acids.'' In: ''Biochem J.'' 68(4), Apr 1958, S. 627–636. PMID 13522672. ., 5-methylcytosineB. F. Vanyushin, S. G. Tkacheva, A. N. Belozersky: ''Rare bases in animal DNA.'' In: ''Nature.'' 225, 1970, S. 948–949. PMID 4391887. and N4-m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histone Modification
In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn are wrapped into 30- nanometer fibers that form tightly packed chromatin. Histones prevent DNA from becoming tangled and protect it from DNA damage. In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 90 micrometers (0.09 mm) of 30 nm diameter chromatin fibers. There are five families of histones which are designated H1/H5 (linker histones), H2, H3, and H4 (core histones). The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer. The tight wrapping of DNA around hist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marshall Nirenberg
Marshall Warren Nirenberg (April 10, 1927 – January 15, 2010) was an American biochemist and geneticist. He shared a Nobel Prize in Physiology or Medicine in 1968 with Har Gobind Khorana and Robert W. Holley for "breaking the genetic code" and describing how it operates in protein synthesis. In the same year, together with Har Gobind Khorana, he was awarded the Louisa Gross Horwitz Prize from Columbia University. Biography Nirenberg was born in New York City to a Jewish family, the son of Minerva (Bykowsky) and Harry Edward Nirenberg, a shirtmaker. He developed rheumatic fever as a boy, so the family moved to Orlando, Florida to take advantage of the subtropical climate. He developed an early interest in biology. In 1948 he received his BS degree, and in 1952, a master's degree in zoology from the University of Florida at Gainesville where he was also a member of the Pi Lambda Phi Fraternity.Membership Directory, 2010, Pi Lambda Phi Inc. His dissertation for the Master's thesi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teleology
Teleology (from and )Partridge, Eric. 1977''Origins: A Short Etymological Dictionary of Modern English'' London: Routledge, p. 4187. or finalityDubray, Charles. 2020 912Teleology" In ''The Catholic Encyclopedia'' 14. New York: Robert Appleton Company. Retrieved 3 May 2020. – via ''New Advent'', transcribed by D. J. Potter is a reason or an explanation for something which serves as a function of its end, its purpose, or its goal, as opposed to something which serves as a function of its cause. A purpose that is imposed by human use, such as the purpose of a fork to hold food, is called ''extrinsic''. ''Natural teleology,'' common in classical philosophy, though controversial today, contends that natural entities also have ''intrinsic'' purposes, regardless of human use or opinion. For instance, Aristotle claimed that an acorn's intrinsic ''telos'' is to become a fully grown oak tree. Though ancient atomists rejected the notion of natural teleology, teleological accounts of non ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Dembski
William Albert Dembski (born July 18, 1960) is an American mathematician, philosopher and theologian. He was a proponent of intelligent design (ID) pseudoscience, specifically the concept of specified complexity, and was a senior fellow of the Discovery Institute's Center for Science and Culture (CSC). On September 23, 2016, he officially retired from intelligent design, resigning all his "formal associations with the ID community, including isDiscovery Institute fellowship of 20 years". A February 2021 interview in the CSC's blog '' Evolution News'' announced "his return to the intelligent design arena". In 2012, he taught as the ''Phillip E. Johnson Research Professor of Science and Culture'' at the Southern Evangelical Seminary in Matthews, North Carolina near Charlotte. Dembski has written books about intelligent design, including '' The Design Inference'' (1998), '' Intelligent Design: The Bridge Between Science & Theology'' (1999), ''The Design Revolution'' (2004), ''T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Creationism
Creationism is the religious belief that nature, and aspects such as the universe, Earth, life, and humans, originated with supernatural acts of divine creation. Gunn 2004, p. 9, "The ''Concise Oxford Dictionary'' says that creationism is 'the belief that the universe and living organisms originated from specific acts of divine creation.'" In its broadest sense, creationism includes a continuum of religious views, Haarsma 2010, p. 168, "Some Christians, often called 'Young Earth creationists,' reject evolution in order to maintain a semi-literal interpretation of certain biblical passages. Other Christians, called 'progressive creationists,' accept the scientific evidence for some evolution over a long history of the earth, but also insist that God must have performed some miracles during that history to create new life-forms. Intelligent design, as it is promoted in North America is a form of progressive creation. Still other Christians, called theistic evolutionists' or 'ev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Huffington Post
''HuffPost'' (formerly ''The Huffington Post'' until 2017 and sometimes abbreviated ''HuffPo'') is an American progressive news website, with localized and international editions. The site offers news, satire, blogs, and original content, and covers politics, business, entertainment, environment, technology, popular media, lifestyle, culture, comedy, healthy living, women's interests, and local news featuring columnists. It was created to provide a progressive alternative to the conservative news websites such as the Drudge Report. The site offers content posted directly on the site as well as user-generated content via video blogging, audio, and photo. In 2012, the website became the first commercially run United States digital media enterprise to win a Pulitzer Prize. Founded by Andrew Breitbart, Arianna Huffington, Kenneth Lerer, and Jonah Peretti, the site was launched on May 9, 2005 as a counterpart to the Drudge Report. In March 2011, it was acquired by AOL for US$315&n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Repair
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages (interstrand crosslinks or ICLs). This can eventually lead to malignant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
