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Nikkomycin
Nikkomycins are a group of antifungal medications. They work by interfering with the building of the fungal cell wall which results in the fungal cell breaking open. They were discovered in 1976. The specific agent nikkomycin Z has weak activity against ''Aspergillus fumigatus'' which may be of benefit when used with other medications, such as caspofungin, ranconazole and amphotericin B, fluconazole or itraconazole. Nikkomycin Z also inhibits growth of ''Batrachochytrium dendrobatidis ''Batrachochytrium dendrobatidis'' ( ), also known as ''Bd'' or the amphibian chytrid fungus, is a fungus that causes the disease chytridiomycosis in amphibians. Since its discovery in 1998 by Lee Berger, the disease devastated amphibian popula ...'', a serious fungal pathogen linked to global amphibian declines, while lower concentrations of Nikkomycin Z enhanced natural amphibian antimicrobial skin peptide effectiveness ''in vitro''. Originally identified from '' Streptomyces tendae'', the nik ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nikkomycin Z
Nikkomycins are a group of antifungal medications. They work by interfering with the building of the fungal cell wall which results in the fungal cell breaking open. They were discovered in 1976. The specific agent nikkomycin Z has weak activity against ''Aspergillus fumigatus'' which may be of benefit when used with other medications, such as caspofungin, ranconazole and amphotericin B, fluconazole or itraconazole. Nikkomycin Z also inhibits growth of ''Batrachochytrium dendrobatidis'', a serious fungal pathogen linked to global amphibian declines, while lower concentrations of Nikkomycin Z enhanced natural amphibian antimicrobial skin peptide effectiveness ''in vitro''. Originally identified from ''Streptomyces tendae ''Streptomyces tendae'' is a bacterium species from the genus of ''Streptomyces'' which has been isolated from soil in France.Deutsche Sammlung von Mikroorganismen und Zellkulturenbr>/ref> ''Streptomyces tendae'' produces carbomycin, streptofact ...'', the nikk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces Tendae
''Streptomyces tendae'' is a bacterium species from the genus of ''Streptomyces'' which has been isolated from soil in France.Deutsche Sammlung von Mikroorganismen und Zellkulturenbr>/ref> ''Streptomyces tendae'' produces carbomycin, streptofactin, geosmin, cervimycin A-D and nikkomycins. Also said to be the source of Tendamistat (HOE 467), an alpha amylase inhibitor. Further reading * * * * * * See also * List of Streptomyces species A ''list'' is any set of items in a row. List or lists may also refer to: People * List (surname) Organizations * List College, an undergraduate division of the Jewish Theological Seminary of America * SC Germania List, German rugby union ... References External linksType strain of ''Streptomyces tendae'' at Bac''Dive'' - the Bacterial Diversity Metadatabase tendae Bacteria described in 1958 {{Streptomyces-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antifungal Medication
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually yes obtained by a doctor's prescription, but a few are available over the counter (OTC). Types of antifungal There are two types of antifungals: local and systemic. Local antifungals are usually administered topically or vaginally, depending on the condition being treated. Systemic antifungals are administered orally or intravenously. Of the clinically employed azole antifungals, only a handful are used systemically. These include ketoconazole, itraconazole, fluconazole, fosfluconazole, voriconazole, posaconazole, and isavuconazole. Examples of non-azole systemic antifungals include griseofulvin and terbinafine. Classes Polyenes A polyene is a molecule with multiple conjugated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aspergillus Fumigatus
''Aspergillus fumigatus'' is a species of fungus in the genus ''Aspergillus'', and is one of the most common ''Aspergillus'' species to cause disease in individuals with an immunodeficiency. ''Aspergillus fumigatus'', a saprotroph widespread in nature, is typically found in soil and decaying organic matter, such as compost heaps, where it plays an essential role in carbon and nitrogen recycling. Colonies of the fungus produce from conidiophores; thousands of minute grey-green conidia (2–3 μm) which readily become airborne. For many years, ''A. fumigatus'' was thought to only reproduce asexually, as neither mating nor meiosis had ever been observed. In 2008, ''A. fumigatus'' was shown to possess a fully functional sexual reproductive cycle, 145 years after its original description by Fresenius. Although ''A. fumigatus'' occurs in areas with widely different climates and environments, it displays low genetic variation and a lack of population genetic differentiation on a globa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caspofungin
Caspofungin (INN) (brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc. discovered by James Balkovec, Regina Black and Frances A. Bouffard. It is a member of a new class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall. Caspofungin was the first inhibitor of fungal (1→3)-β-D-glucan synthesis to be approved by the United States Food and Drug Administration. Caspofungin is administered intravenously. It is on the World Health Organization's List of Essential Medicines. Spectrum of Activity Caspofungin has been effective in treating fungal infections caused by ''Aspergillus'' and ''Candida'' species. It is a member of the echinocandin family, a new class of antifungal agents with broad spectrum of activity against all Candida species. In comparison to treatment with either fluconazole or Amphotericin B, all three drugs in this class ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amphotericin B
Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. For certain infections it is given with flucytosine. It is typically given intravenously (injection into a vein). Common side effects include a reaction with fever, chills, and headaches soon after the medication is given, as well as kidney problems. Allergic symptoms including anaphylaxis may occur. Other serious side effects include low blood potassium and myocarditis (inflammation of the heart). It appears to be relatively safe in pregnancy. There is a lipid formulation that has a lower risk of side effects. It is in the polyene class of medications and works in part by interfering with the cell membrane of the fungus. Amphotericin B was isolated from '' Streptomyces nodosus'' in 1955 at the Squibb For Medical Research Institute from c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluconazole
Fluconazole is an antifungal medication used for a number of fungal infections. This includes candidiasis, blastomycosis, coccidiodomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and pityriasis versicolor. It is also used to prevent candidiasis in those who are at high risk such as following organ transplantation, low birth weight babies, and those with neutropenia, low blood neutrophil counts. It is given either by mouth or by intravenous, injection into a vein. Common side effects include vomiting, diarrhea, rash, and elevated transaminases, increased liver enzymes. Serious side effects may include liver problems, QT prolongation, and seizures. During pregnancy it may increase the risk of miscarriage while large doses may cause birth defects. Fluconazole is in the azole antifungal family of medication. It is believed to work by affecting the fungal cellular membrane. Fluconazole was patented in 1981 and came into commercial use in 1988. It is on the WHO Model Lis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Itraconazole
Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. It may be given by mouth or intravenously. Common side effects include nausea, diarrhea, abdominal pain, rash, and headache. Severe side effects may include liver problems, heart failure, Stevens–Johnson syndrome and allergic reactions including anaphylaxis. It is unclear if use during pregnancy or breastfeeding is safe. It is in the triazole family of medications. It stops fungal growth by affecting the cell membrane or affecting their metabolism. Itraconazole was patented in 1978 and approved for medical use in the United States in 1992. It is on the World Health Organization's List of Essential Medicines. Recent research works suggest itraconazole (ITZ) could also be used in the treatment of cancer by inhibiting the hedgehog pathway in a similar way to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Batrachochytrium Dendrobatidis
''Batrachochytrium dendrobatidis'' ( ), also known as ''Bd'' or the amphibian chytrid fungus, is a fungus that causes the disease chytridiomycosis in amphibians. Since its discovery in 1998 by Lee Berger, the disease devastated amphibian populations around the world, in a global decline towards multiple extinctions, part of the Holocene extinction. A recently described second species, '' B. salamandrivorans'', also cause chytridiomycosis and death in salamanders. The fungal pathogens that cause the disease chytridiomycosis ravage the skin of frogs, toads, and other amphibians, throwing off their balance of water and salt and eventually causing heart failure, Nature reports. Some amphibian species appear to have an innate capacity to withstand chytridiomycosis infection due to symbiosis with ''Janthinobacterium lividum''. Even within species that generally succumb, some populations survive, possibly demonstrating that these traits or alleles of species are being subjected to evo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chitin Synthase
In enzymology, a chitin synthase () is an enzyme that catalyzes the chemical reaction :UDP-N-acetyl-D-glucosamine + ,4-(N-acetyl-beta-D-glucosaminyl) \rightleftharpoons UDP + ,4-(N-acetyl-beta-D-glucosaminyl)+1 Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and ,4-(N-acetyl-beta-D-glucosaminyl), whereas its two products are UDP and ,4-(N-acetyl-beta-D-glucosaminyl)+1. This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase. Other names in common use include chitin-UDP N-acetylglucosaminyltransferase, chitin-uridine diphosphate acetylglucosaminyltransferase, chitin synthetase, and trans-N-acetylglucosaminosylase. This enzyme participates in aminosugars metabolism. Production Chitin Synthase is manufactured in the rough endoplasmic reticulum of fungi as the inactive form, zymogen. The zymog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
