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Naphthoate Synthase
The enzyme 1,4-dihydroxy-2-naphthoyl-CoA synthase () catalyzes the sixth step in the biosynthesis of phylloquinone and menaquinone, the two forms of vitamin K. In ''Escherichia coli, E. coli,'' 1,4-dihydroxy-2-naphthoyl-CoA synthase, formerly known as naphthoate synthase, is encoded by menB and uses O-succinylbenzoyl-CoA as a Substrate (biochemistry), substrate and converts it to 1,4-dihydroxy-2-naphthoyl-CoA. Nomenclature MenB is part of the crotonase fold super family, named after the Crotonase family, crotonase fold in their structure. The List of enzymes, systematic name for MenB is 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dehydratase (cyclizing). Other common names include: * Naphthoate synthase * 1,4-dihydroxy-2-naphthoate synthase * Dihydroxynaphthoate synthase * DHNA-CoA synthase Reaction It was originally thought that the product of this reaction had an oxygen where the SCoA currently resides, however; new research has shown that MenB only catalyzes the above reaction. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
