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Matrix Metalloproteinase Inhibitor
A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular dire ... they have antiangiogenic effects. They may be both endogenous and exogenous. The most notorious ''endogenous'' metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs). There are also cartilage-derived angiogenesis inhibitors. ''Exogenous'' matrix metalloproteinase inhibitors were developed as anticancer drugs. Examples include: * Batimastat * Cipemastat * Ilomastat * Marimastat * MMI270 * Prinomastat * Rebimastat * Ro 28-2653 * Tanomastat Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae, and bacteria. See also * Drug discovery and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matrix Metalloproteinase
Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively, these enzymes are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense. They were first described in vertebrates (1962), including humans, but have since been found in invertebrates and plants. They are distinguished from other endopeptida ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MMI270
MMI may refer to: Science and technology * Man-machine interface or user interface * Modified Mercalli intensity scale, an earthquake intensity measure * W3C MMI or Multimodal Interaction Activity * Monolithic Memories, Inc. (1969–1987), an American semiconductor manufacturer * Motorola Mobility (NYSE: MMI), a publicly traded electronics company, formerly part of Motorola * Multi Media Interface, an in-car interface system developed by Audi * Maximum mutual information criterion * Methimazole, a drug used to treat hyperthyroidism * Multi mode interferometer * Modified Mecalli Index Music * Miss May I, a metalcore band from Ohio * Madurai Mani Iyer, Indian singer Schools * Marion Military Institute, a military junior college in Marion, Alabama * Marymount International School of Rome, a private Catholic school in Rome, Italy * Miami Military Institute, a former military college that was located in Germantown, Ohio * Millersburg Military Institute, a defunct military ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angiology
Angiology (from Ancient Greek, Greek , ''angeīon'', "vessel"; and , ''wiktionary:-logia, -logia'') is the medical specialty dedicated to studying the circulatory system and of the lymphatic system, i.e., arteries, veins and lymphatic vessels. In the United Kingdom, UK, this field is more often termed ''angiology'', and in the United States the term vascular medicine is more frequent. The field of vascular medicine (angiology) is the field that deals with preventing, diagnosing and treating vascular and blood vessel related diseases. Overview Arterial diseases include the aorta (aortic aneurysm, aneurysms/aortic dissection, dissection) and arteries supplying the legs, hands, kidneys, brain, intestines. It also covers arterial thrombosis and embolism; vasculitides; and vasospasm, vasospastic disorders. Naturally, it deals with preventing cardiovascular diseases such as myocardial infarction, heart attack and stroke. Venous diseases include venous thrombosis, chronic Chronic ve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Discovery And Development Of MMP Inhibitors
Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs). MMPs belong to a family of zinc-dependent neutral endopeptidases. These enzymes have the ability to break down connective tissue. The expression of MMPs is increased in various pathological conditions like inflammatory conditions, metabolic bone disease, to cancer invasion, metastasis and angiogenesis. Examples of diseases are periodontitis, hepatitis, glomerulonephritis, atherosclerosis, emphysema, asthma, autoimmune disorders of skin and dermal photoaging, rheumatoid arthritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, chronic ulcerations, uterine involution, corneal epithelial defects, bone resorption and tumor progression and metastasis. Due to the role of MMPs in pathological conditions, inhibitors of MMPs may have therapeutic potential. Several other proteins have similar inhibitory effects, however none as effective (netrins, procollagen C-terminal proteinase en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tanomastat
Tanomastat is a matrix metalloproteinase inhibitor (MMPI). Excision of malignant tumors comprises first line treatment for cancer of solid tissues. This procedure not infrequently misses small fragments of the tumor that may have broken off before surgery from the principal site of the disease. These fragments, metastases, often proliferate at quite remote locations where they cause much of the pathology of cancer. A series of proteolytic enzymes present in tumor cells, known as matrix metalloproteinases, help establish growth of these metastases at the newly invaded sites; these proteases are also involved in the formation of new blood vessels that will nourish the invasive cell masses. Consequently, considerable research has been devoted to matrix metalloproteinases Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prinomastat
Prinomastat (code name AG-3340) is a matrix metalloproteinase (MMP) inhibitor with specific selectivity for MMPs 2, 3, 9, 13, and 14. Investigations have been carried out to determine whether the inhibition of these MMPs is able to block tumour metastasis by preventing MMP degradation of the extracellular matrix proteins and angiogenesis. Prinomastat underwent a Phase III trial to investigate its effectiveness against non-small cell lung cancer (NSCLC), in combination with gemcitabine chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemothe .... However, it was discovered that Prinomastat did not improve the outcome of chemotherapy in advanced non-small-cell lung cancer. References {{reflist Experimental cancer drugs Hydroxamic acids Matrix metalloproteinase inhibitors S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marimastat
Marimastat was a proposed antineoplastic drug developed by British Biotech. It acted as a broad-spectrum matrix metalloproteinase inhibitor A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic d .... Marimastat performed poorly in clinical trials, and development was terminated. This may be, however, a result of targeting cancer at too late of a stage. This is supported by the fact that MMP inhibitors have more recently been shown in animal models to be more effective in earlier stages of cancers. (Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 284, 808-812. Bergers, G., Javaherian, K., Lo, K.-M., Folkman, J., and Hanahan, D. (1999)). See also * Batimastat References Experimental cancer drugs Hydroxamic acids Matrix metalloproteinase inhibito ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Migration
Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations. Cells often migrate in response to specific external signals, including chemical signals and mechanical signals. Errors during this process have serious consequences, including intellectual disability, vascular disease, tumor formation and metastasis. An understanding of the mechanism by which cells migrate may lead to the development of novel therapeutic strategies for controlling, for example, invasive tumour cells. Due to the highly viscous environment (low Reynolds number), cells need to continuously produce forces in order to move. Cells achieve active movement by very different mechanisms. Many less complex prokaryotic organisms (and sperm cells) use flagella or cilia to propel themselves. Eukaryot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ilomastat
Ilomastat (INN), (codenamed GM6001, proprietary name Galardin®) is a broad-spectrum matrix metalloproteinase inhibitor. This chemotherapy agent is considered to have application in skincare products for its antiaging properties. Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc. Examples of enzymes that ilomastat inhibit include rabbit MMP9, thermolysin, peptide deformylase In enzymology, a peptide deformylase () is an enzyme that catalyzes the chemical reaction :H2O + formyl-L-methionyl peptide \rightleftharpoons methionyl peptide + formate Thus, the two substrates of this enzyme are formyl-L-methionyl peptide ..., and anthrax lethal factor endopeptidase (LF) produced by the bacterium '' Bacillus anthracis''.; References {{Reflist Hydroxamic acids Matrix metalloproteinase inhibitors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cipemastat
Cipemastat (rINN, also known as Ro 32-3555 and by the tentative trade name Trocade) is a selective inhibitor of matrix metalloproteinase-1 that has been investigated as an anti- arthritis agent. It is being developed by Roche F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX .... References Hydantoins Hydroxamic acids Matrix metalloproteinase inhibitors 1-Piperidinyl compounds {{musculoskeletal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
