A matrix metalloproteinase inhibitor (MMPI) inhibits
matrix metalloproteinase
Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs be ...
s. As they inhibit
cell migration
Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular dire ...
they have
antiangiogenic effects. They may be both endogenous and exogenous.
The most notorious ''endogenous'' metalloproteinases are
tissue inhibitors of metalloproteinases (TIMPs). There are also
cartilage-derived angiogenesis inhibitors.
''Exogenous'' matrix metalloproteinase inhibitors were developed as anticancer drugs.
Examples include:
*
Batimastat
*
Cipemastat
*
Ilomastat
*
Marimastat
*
MMI270
*
Prinomastat
*
Rebimastat
*
Ro 28-2653
*
Tanomastat
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae, and bacteria.
See also
*
Drug discovery and development of MMP inhibitors
References
Angiology
Biochemistry
{{biochemistry-stub