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Magic Bullet (medical)
The magic bullet is a scientific concept developed by a German Nobel laureate Paul Ehrlich in 1907. [Reprint of "Experimental Researches on Specific Therapy: On Immunity with special Reference to the Relationship between Distribution and Action of Antigens" from ''The Harben Lectures for 1907 of the Royal Institute of Public Health'', London: Lewis, 1908] While working at the Institute of Experimental Therapy (''Institut für experimentelle Therapie''), Ehrlich formed an idea that it could be possible to kill specific Microorganism, microbes (such as bacteria), which cause diseases in the body, without harming the body itself. He named the hypothetical agent as ''Zauberkugel,'' and used the English translation "magic bullet" in The Harben Lectures at London. The name itself is a reference to an old German myth about a bullet that cannot miss its target. Erlich had in mind Carl Maria von Weber's popular 1821 opera ''Der Freischütz'', in which a young hunter is required to hit an impos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Ehrlich
Paul Ehrlich (; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology, and antimicrobial chemotherapy. Among his foremost achievements were finding a cure for syphilis in 1909 and inventing the precursor technique to Gram staining bacteria. The methods he developed for staining tissue made it possible to distinguish between different types of blood cells, which led to the ability to diagnose numerous blood diseases. His laboratory discovered arsphenamine (Salvarsan), the first effective medicinal treatment for syphilis, thereby initiating and also naming the concept of chemotherapy. Ehrlich popularized the concept of a magic bullet. He also made a decisive contribution to the development of an antiserum to combat diphtheria and conceived a method for standardizing therapeutic serums. In 1908, he received the Nobel Prize in Physiology or Medicine for his contributions to immunology. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kiyoshi Shiga
was a Japanese physician and bacteriologist. He had a well-rounded education and career that led to many scientific discoveries. In 1897, Shiga was credited with the discovery and identification of the ''Shigella'' ''dysenteriae'' microorganism which causes dysentery, and the Shiga toxin which is produced by the bacteria. He conducted research on other diseases such as tuberculosis and trypanosomiasis, and made many advancements in bacteriology and immunology. Personal life Shiga was born in Sendai, Miyagi Prefecture. His original surname was Satō, but he changed it to his mother's maiden name, Shiga, after being brought up by his maternal family. Shiga was raised during Japan's Industrial age and restoration. The changing times put financial troubles on his family. In 1900, Kiyoshi Shiga married Ichiko Shiga and in the following years had eight children. He faced many family hardships. Shiga lost his wife in 1944 to stomach cancer, his eldest son to turbulent seas during a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
US Public Health Service
The United States Public Health Service (USPHS or PHS) is a collection of agencies of the Department of Health and Human Services concerned with public health, containing nine out of the department's twelve operating divisions. The Assistant Secretary for Health oversees the PHS. The Public Health Service Commissioned Corps (PHSCC) is the federal uniformed service of the PHS, and is one of the eight uniformed services of the United States. PHS had its origins in the system of marine hospitals that originated in 1798. In 1871 these were consolidated into the Marine Hospital Service, and shortly afterwards the position of Surgeon General and the PHSCC were established. As the system's scope grew to include quarantine authority and research, it was renamed the Public Health Service in 1912. A series of reorganizations in 1966–1973 began a shift where PHS' divisions were promoted into departmental operating agencies. PHS was established as a thin layer of hierarchy above t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edward G
Edward is an English given name. It is derived from the Anglo-Saxon name ''Ēadweard'', composed of the elements '' ēad'' "wealth, fortune; prosperous" and '' weard'' "guardian, protector”. History The name Edward was very popular in Anglo-Saxon England, but the rule of the Norman and Plantagenet dynasties had effectively ended its use amongst the upper classes. The popularity of the name was revived when Henry III named his firstborn son, the future Edward I, as part of his efforts to promote a cult around Edward the Confessor, for whom Henry had a deep admiration. Variant forms The name has been adopted in the Iberian peninsula since the 15th century, due to Edward, King of Portugal, whose mother was English. The Spanish/Portuguese forms of the name are Eduardo and Duarte. Other variant forms include French Édouard, Italian Edoardo and Odoardo, German, Dutch, Czech and Romanian Eduard and Scandinavian Edvard. Short forms include Ed, Eddy, Eddie, Ted, Teddy and Ned. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Dieterle
William Dieterle (July 15, 1893 – December 9, 1972) was a German-born actor and film director who emigrated to the United States in 1930 to leave a worsening political situation. He worked in Cinema of the United States, Hollywood primarily as a director for much of his career, becoming a United States citizen in 1937. He moved back to Germany in the late 1950s. His best-known films include ''The Story of Louis Pasteur'' (1936), ''The Hunchback of Notre Dame (1939 film), The Hunchback of Notre Dame'' (1939) and ''The Devil and Daniel Webster (film), The Devil and Daniel Webster'' (1941). His film ''The Life of Emile Zola'' (1937) won the Academy Award for Best Picture, the second biographical feature to do so. Early life and career He was born Wilhelm Dieterle in Ludwigshafen, the youngest child of nine, to factory worker Jacob and Berthe (Doerr) Dieterle. As a child, he lived in considerable poverty and earned money by various means, including carpentry and as a scrap dealer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Warner Bros
Warner Bros. Entertainment Inc. (commonly known as Warner Bros. or abbreviated as WB) is an American film and entertainment studio headquartered at the Warner Bros. Studios complex in Burbank, California, and a subsidiary of Warner Bros. Discovery. Founded in 1923 by four brothers, Harry, Albert, Sam, and Jack Warner, the company established itself as a leader in the American film industry before diversifying into animation, television, and video games and is one of the "Big Five" major American film studios, as well as a member of the Motion Picture Association (MPA). The company is known for its film studio division the Warner Bros. Pictures Group, which includes Warner Bros. Pictures, New Line Cinema, the Warner Animation Group, Castle Rock Entertainment, and DC Studios. Among its other assets, stands the television production company Warner Bros. Television Studios. Bugs Bunny, a cartoon character created by Tex Avery, Ben Hardaway, Chuck Jones, Bob Givens and Robe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Institute Of Public Health
Royal Institute of Public Health merged in 2008 with the Royal Society for Health to form Royal Society for Public Health (RSPH). History The institute was the amalgamation of a few societies. The Metropolitan Association of Medical Officers of Health was an English society of metropolitan Medical Officer for Health established on 3 April 1856. In 1869 "Metropolitan" was dropped from the title, and in 1873 it became the Society of Medical Officers of Health, and in 1989 it became the Society of Public Health. Timeline Presidents Past presidents include: * John Simon, first presidentMichael Warren1850-1899 A Chronology of State Medicine, Public Health, Welfare and Related Services in Britain: 1066 - 1999. * Lawson Soulsby, Baron Soulsby of Swaffham Prior *Nora Wattie Publications * ''Public Health'' (journal), now owned by Royal Society for Public Health. Previous publications * ''Journal of State Medicine'' * ''Health & Hygiene Health, according to the World H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sahachiro Hata
was a prominent Japanese bacteriologist who researched the bubonic plague under Kitasato Shibasaburō and assisted in developing the Arsphenamine drug in 1909 in the laboratory of Paul Ehrlich. Hata received three unsuccessful nominations for the Nobel Prize, one from Swiss surgeon Emil Kocher for Chemistry in 1911 and two by Japanese colleagues Hayazo Ito and G Osawa for Physiology or Medicine in 1912 and 1913, respectively. Early life Hata was born in Tsumo Village, Shimane prefecture (now part of Masuda City) as the eighth son of the Yamane family. At the age of 14, he was adopted by the Hata family, whose male members were doctors from generation to generation. Hata completed his medical education in Okayama at the Third Higher School of Medicine (now Okayama University School of Medicine). In 1897, he became an assistant at Okayama Prefectural Hospital where he learned internal medicine from Zenjiro Inoue and biochemistry from Torasaburo Araki. Plague Research S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arsphenamine
Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis, relapsing fever, and African trypanosomiasis. This organoarsenic compound was the first modern antimicrobial agent. History Arsphenamine was first synthesized in 1907 in Paul Ehrlich's lab by Alfred Bertheim. The antisyphilitic activity of this compound was discovered by Sahachiro Hata in 1909, during a survey of hundreds of newly synthesized organic arsenical compounds. Ehrlich had theorized that by screening many compounds, a drug could be discovered that would have anti-microbial activity but not kill the human patient. Ehrlich's team began their search for such a " magic bullet" among chemical derivatives of the dangerously toxic drug atoxyl. This project was the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications, the basis for nearly all ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Treponema Pallidum
''Treponema pallidum'', formerly known as ''Spirochaeta pallida'', is a spirochaete bacterium with various subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. It is transmitted only among humans. It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. ''T. pallidum'''s lack of either a tricarboxylic acid cycle or oxidative phosphorylation results in minimal metabolic activity. The treponemes have a cytoplasmic and an outer membrane. Using light microscopy, treponemes are visible only by using dark field illumination. ''Treponema pallidum'' consists of three subspecies, ''T. p. pallidum, T. p. endemicum,'' and ''T. p. pertenue,'' each of which has a distinct associated disease. Subspecies Three subspecies of ''T. pallidum'' are known: * ''Treponema pallidum pallidum'', which causes syphilis * ''T. p. endemicum'', which causes bejel or endemic syphilis * ''T. p. pertenue'', which causes yaws T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erich Hoffmann
Erich Hoffmann (25 April 1868 – 8 May 1959) was a German dermatologist who was a native of Witzmitz, Pomerania. He studied medicine at the Berlin Military Academy, and was later a professor at the Universities of Halle and Bonn. Hoffmann is remembered for his research performed with zoologist Fritz Schaudinn (1871-1906) at the Charité Clinic in Berlin. In 1905 Schaudinn and Hoffmann discovered the bacterium that was responsible for syphilis, a spiral-shaped spirochete called ''Treponema pallidum''. The organism was removed from a papula in the vulva of a patient with secondary syphilis. The two doctors documented their findings in a treatise called ''Vorläufiger Bericht über das Vorkommen von Spirochaeten in syphilitischen Krankheitsprodukten und bei Papillome''.Fritz Richard Schaudinn, Erich Hoffmann: Vorläufiger Bericht über das Vorkommen von Spirochaeten in syphilitischen Krankheitsprodukten und bei Papillomen. Arbeiten aus dem kaiserlichen Gesundheitsamtes (Berlin) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fritz Schaudinn
Fritz Richard Schaudinn (19 September 1871 – 22 June 1906) was a German zoologist. Born in Röseningken, East Prussia, he co-discovered, with Erich Hoffmann in 1905, the causative agent of syphilis, ''Spirochaeta pallida'' (also known as ''Treponema pallidum''). The work was carried out at the Berlin Charité. Among Schaudinn's other contributions to medicine include his work in the field of amoebic dysentery and sleeping sickness, his confirmation of the work of Sir Ronald Ross and Giovanni Battista Grassi (1854–1925) in the field of malaria research. He also demonstrated that human hookworm infection is contracted through the skin of the feet. He made noted contributions to zoology and was one of the developers of protozoology as an experimental science. Schaudinn was a graduate in zoology of the Friedrich Wilhelm University in Berlin. Since 2002 an annual medical prize has been awarded in his name. In 1898 with zoologist Fritz Römer (1866–1909), he participated on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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