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Methylecgonine
Methylecgonine is a prominent tropane alkaloid found in coca leaves. It is metabolite of cocaine, and maybe is used as precursor for it. It also occurs as minor alkaloid in roots of many ''Datura'' species such as '' Datura stramonium'' and '' Datura innoxia''. Biosynthesis It is the last step before cocaine is biosynthesized in coca plants with the help of BAHD acyltransferase. Animal study Animals study suggest that it has beneficial effect on cognition and protects against cocaine lethality. It showed inhibition of sodium channels only at very high dosages. See also * Ecgonine Ecgonine (tropane derivative) is a tropane alkaloid found naturally in coca leaves. It has a close structural relation to cocaine: it is both a metabolite and a precursor, and as such, it is a controlled substance in many jurisdictions, as are so ... References Tropane alkaloids {{Alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cocaine
Cocaine (from , from , ultimately from Quechuan languages, Quechua: ''kúka'') is a central nervous system (CNS) stimulant mainly recreational drug use, used recreationally for its euphoria, euphoric effects. It is primarily obtained from the leaves of two Coca species native to South America, ''Erythroxylum coca'' and ''Erythroxylum novogranatense''. After extraction from coca leaves and further processing into cocaine hydrochloride (powdered cocaine), the drug is often Insufflation (medicine), snorted, applied topical administration, topically to the mouth, or dissolved and injection (medicine), injected into a vein. It can also then be turned into free base form (crack cocaine), in which it can be heated until sublimated and then the vapours can be smoking, inhaled. Cocaine stimulates the mesolimbic pathway, reward pathway in the brain. Mental effects may include an euphoria, intense feeling of happiness, sexual arousal, psychosis, loss of contact with reality, or psychomo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ecgonine
Ecgonine (tropane derivative) is a tropane alkaloid found naturally in coca leaves. It has a close structural relation to cocaine: it is both a metabolite and a precursor, and as such, it is a controlled substance in many jurisdictions, as are some substances which can be used as precursors to ecgonine itself. Structurally, ecgonine is a cycloheptane derivative with a nitrogen bridge. It is obtained by hydrolysis of cocaine with acids or alkalis, and crystallizes with one molecule of water, the crystals melting at 198–199 °C. It is levorotary, and on warming with alkalis gives iso-ecgonine, which is dextrorotary. It is a tertiary base, and has the properties of an acid and an alcohol. It is the carboxylic acid corresponding to tropine, for it yields the same products on oxidation, and by treatment with phosphorus pentachloride is converted into anhydroecgonine, C9H13NO2, which, when heated to 280 °C with hydrochloric acid, eliminates carbon dioxide and yields tro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tropane Alkaloid
Tropane alkaloids are a class of bicyclic [3.2.1] alkaloids and secondary metabolites that contain a tropane ring in their chemical structure. Tropane alkaloids occur naturally in many members of the plant family Solanaceae. Certain tropane alkaloids such as cocaine and scopolamine are notorious for their psychoactive effects, related usage and cultural associations. Particular tropane alkaloids such as these have pharmacological properties and can act as anticholinergics or stimulants. Classification Anticholinergics Anticholinergic drugs and deliriants: * Atropine, racemate, racemic hyoscyamine, from the deadly nightshade (''Atropa belladonna'') * Hyoscyamine, the ''levo''-isomer of atropine, from henbane (''Hyoscyamus niger''), mandrake (''Mandragora officinarum'') and the sorcerers' tree (''Latua pubiflora''). * Hyoscine hydrobromide, Scopolamine, from henbane and ''Datura'' species (Jimson weed) All three acetylcholine-inhibiting chemicals can also be found in the leave ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythroxylum Coca
''Erythroxylum coca'' is one of two species of cultivated coca. Description The coca plant resembles a blackthorn bush, and grows to a height of . The branches are straight, and the leaves, which have a green tint, are thin, opaque, oval, and taper at the extremities. A marked characteristic of the leaf is an areolated portion bounded by two longitudinal curved lines, one line on each side of the midrib, and more conspicuous on the underside of the leaf. The flowers are small, and disposed in little clusters on short stalks; the corolla is composed of five yellowish-white petals, the anthers are heart-shaped, and the pistil consists of three carpels united to form a three-chambered ovary. The flowers mature into red berries. Unlike ''Erythroxylum novogranatense'', ''Erythroxylum coca'' requires very acidic soil conditions. Soil acidity and water acidity need to be below pH 5.5, with the optimal value being pH 3.5, similar to that of ''Rhododendron'' potting soils. At pH 6.5 and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Analytical Toxicology
''Journal of Analytical Toxicology'' (JAT) is a peer-reviewed scientific journal focusing on analytical toxicology. According to ''Journal Citation Reports'' it received an impact factor of 3.513, ranking it 23rd out of 92 journals in the category "Toxicology" and 20th out of 86 journals in the category "Analytical Chemistry". The editor is Bruce A. Goldberger (University of Florida The University of Florida (Florida or UF) is a public land-grant research university in Gainesville, Florida. It is a senior member of the State University System of Florida, traces its origins to 1853, and has operated continuously on its ..., Gainesville). JAT is the official journal of the Society of Forensic Toxicologists. accessed on January 13th, 2018 External links *References {{Reflist[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Datura
''Datura'' is a genus of nine species of highly poisonous, vespertine-flowering plants belonging to the nightshade family Solanaceae. They are commonly known as thornapples or jimsonweeds, but are also known as devil's trumpets (not to be confused with angel's trumpets, which are placed in the closely related genus ''Brugmansia''). Other English common names include moonflower, devil's weed, and hell's bells. All species of ''Datura'' are extremely poisonous and potentially psychoactive, especially their seeds and flowers, which can cause respiratory depression, arrhythmias, fever, delirium, hallucinations, anticholinergic syndrome, psychosis, and even death if taken internally. Due to their effects and symptoms, they have occasionally been used not only as poisons, but also as hallucinogens by various groups throughout history. Traditionally, psychoactive administration of ''Datura'' species has often been associated with witchcraft and sorcery or similar practices in man ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Datura Stramonium
''Datura stramonium'', known by the common names thorn apple, jimsonweed (jimson weed), devil's snare, or devil's trumpet, is a poisonous flowering plant of the nightshade family Solanaceae. It is a species belonging to the ''Datura'' genus and '' Daturae'' tribe. Its likely origin was in Central America, and it has been introduced in many world regions. It is an aggressive invasive weed in temperate climates across the world. ''D. stramonium'' has frequently been employed in traditional medicine to treat a variety of ailments. It has also been used as a hallucinogen (of the anticholinergic/antimuscarinic, deliriant type), taken entheogenically to cause intense, sacred or occult visions.Schultes, Richard Evans; Albert Hofmann (1979). ''Plants of the Gods: Origins of Hallucinogenic Use'' New York: McGraw-Hill. . It is unlikely ever to become a major drug of abuse owing to effects upon both mind and body frequently perceived as being highly unpleasant, giving rise to a state of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fitoterapia
''Fitoterapia'' is a peer-reviewed medical journal covering research on the use of medicinal plants and bioactive natural products of plant origin in pharmacotherapy. According to the ''Journal Citation Reports'', ''Fitoterapia'' has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 3.204.. Since 2023 the Editor in Chief is prof. Orazio Taglialatela-Scafati. References External links * English-language journals Elsevier academic journals Publications established in 1930 Pharmacology journals {{pharma-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Datura Innoxia
''Datura innoxia'' (often spelled ''inoxia''), known as pricklyburr, recurved thorn-apple, downy thorn-apple, Indian-apple, lovache, moonflower, nacazcul, toloatzin, toloaxihuitl, tolguache or toloache, is a species of flowering plant in the family Solanaceae. It is more rarely called sacred datura, a common name which is applied more often to the closely related ''Datura wrightii''. It is native to the Southwestern United States, Central and South America, and introduced in Africa, Asia, Australia and Europe. The scientific name is often cited as ''D. innoxia''. When English botanist Philip Miller first described the species in 1768, he misspelled the Latin word ''innoxia'' (inoffensive) when naming it ''D. inoxia''. The name ''Datura meteloides'' was for some time erroneously applied to some members of the species, but that name has now been abandoned. Description ''Datura innoxia'' is a tuberous-rooted subshrub that typically reaches a height of 0.6 to 1.5 metres. Its stems a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BAHD Acyltransferase
{{technical, date=September 2015 General Information The BAHD acyltransferases are a super family of enzymes found primarily in plants, algae and bacteria. They are CoA-dependent enzymes that transfer acylated moieties (RC(O)R’) of an acyl-activated CoA thioester donor to an acceptor molecule (D’Auria, 2006). Members of this enzyme family typically share two conserved amino acid motifs. The first motif, or string of consecutive amino acids, is HXXXD (Histidine, Any, Any, Any, Aspartic acid) and it is typically found in the central region of the protein. The Histidine in this motif has also been shown to act as a catalytic residue in many BAHD enzymes. The second conserved motif is DFGWG (Aspartic acid, Phenylalanine, Glycine, Tryptophan, Glycine) and it is typically found near the carboxyl terminus of the protein and is thought to participate in CoA binding (D'Auria, 2006). Additionally, further information such as currently discovered structures, sequences and gene architectur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plant Physiology
Plant physiology is a subdiscipline of botany concerned with the functioning, or physiology, of plants. Closely related fields include plant morphology (structure of plants), plant ecology (interactions with the environment), phytochemistry (biochemistry of plants), cell biology, genetics, biophysics and molecular biology. Fundamental processes such as photosynthesis, respiration, plant nutrition, plant hormone functions, tropisms, nastic movements, photoperiodism, photomorphogenesis, circadian rhythms, environmental stress physiology, seed germination, dormancy and stomata function and transpiration, both parts of plant water relations, are studied by plant physiologists. Aims The field of plant physiology includes the study of all the internal activities of plants—those chemical and physical processes associated with life as they occur in plants. This includes study at many levels of scale of size and time. At the smallest scale are molecular interactions of photosynthesi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cocaine Intoxication
Cocaine intoxication refers to the subjective, desired and adverse effects of cocaine on the mind and behavior of users. Both self-induced and involuntary cocaine intoxication have medical and legal implications (even in absence of relevant adverse effects). Adverse effects can develop over time due to repeated use and so become chronic conditions. However, even a one-time intake of the substance can result in severe acute intoxication. Recurrent cocaine use and dependence to the drug inevitably leads to the reduction of the desired effects perceived by the users, while the occurrence of adverse effects of intoxication increase. The last can sometimes be completely reversed without bearing consequences but they can also potentially kill the users (e.g., in cases of untreated or non-manageable overdoses). Signs and symptoms Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
