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Khellin
Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. It is a major constituent of the plant '' Ammi visnaga'', also known as Bishop's Weed. Once purified, khellin exists as colorless, odorless, bitter-tasting needle-shaped crystals and is classified as a gamma-pyrone, a furanochromone derivative. In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy. A number of drugs were discovered through this research, such as amiodarone and cromolyn sodium, which are used in current medical practice. Efloxate is also mentioned as analog. Background Khellin is found in Egypt, the Middle East, and areas surrounding the Mediterranean. It is a major constituent of the plant ''Ammi Visnaga'', existing between 0.3 and 1.2% in the leaves and seeds. Bish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ammi Visnaga
''Visnaga daucoides'' is a species of flowering plant in the carrot family known by many common names, including toothpick-plant, toothpickweed, bisnaga, khella, or sometimes bishop's weed. It is native to Europe, Asia, and North Africa, but it can be found throughout the world as an introduced species. Description This is an erect annual plant growing from a taproot to a maximum height near . The leaves are up to long and generally oval to triangular in shape but dissected into many small linear to lance-shaped segments. The inflorescence is a compound umbel of white flowers similar to those of other Apiaceae species. The fruit is a compressed oval-shaped body less than 3 millimeters long. This species is a source of khellin, a diuretic extract. Like its close relative ''Ammi majus'', ''Visnaga daucoides'' is commonly seen in gardens where it is grown from seed annually. Some authorities regard ''Visnaga daucoides'' as a synonym of ''Ammi visnaga''; and it is still widely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amiodarone
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. Evidence in cardiac arrest, however, is poor. It can be given by mouth, intravenously, or intraosseously. When used by mouth, it can take a few weeks for effects to begin. Common side effects include feeling tired, tremor, nausea, and constipation. As amiodarone can have serious side effects, it is mainly recommended only for significant ventricular arrhythmias. Serious side effects include lung toxicity such as interstitial pneumonitis, liver problems, heart arrhythmias, vision problems, thyroid problems, and death. If taken during pregnancy or breastfeeding it can cause problems in the fetus. It is a class III antiarrhythmic medication. It works partly by increasing the time befor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Folk Medicine
Traditional medicine (also known as indigenous medicine or folk medicine) comprises medical aspects of traditional knowledge that developed over generations within the folk beliefs of various societies, including indigenous peoples, before the era of modern medicine. The World Health Organization (WHO) defines traditional medicine as "the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness". Traditional medicine is often contrasted with scientific medicine. In some Asian and African countries, up to 80% of the population relies on traditional medicine for their primary health care needs. When adopted outside its traditional culture, traditional medicine is often considered a form of alternative medicine. Practices known as traditional medicin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psoralens
Psoralen (also called psoralene) is the parent compound in a family of naturally occurring organic compounds known as the linear furanocoumarins. It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of umbelliferone. Psoralen occurs naturally in the seeds of ''Psoralea corylifolia'', as well as in the common fig, celery, parsley, West Indian satinwood, and in all citrus fruits. It is widely used in PUVA (psoralen + UVA) treatment for psoriasis, eczema, vitiligo, and cutaneous T-cell lymphoma; these applications are typically through the use of medications such as Methoxsalen. Many furanocoumarins are extremely toxic to fish, and some are deposited in streams in Indonesia to catch fish. Uses Psoralen is a mutagen, and is used for this purpose in molecular biology research. Psoralen intercalates into DNA and on exposure to ultraviolet (UVA) radiation can form monoadducts and covalent interstrand cross-links (I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Furanochromones
Furanochromone is a chemical compound which is a derivative of chromone (1,4-benzopyrone) and furan. Some chemical derivatives of furanochromone show strong interaction with DNA. Furanochromones can be produced in callus cultures of ''Ammi visnaga ''Visnaga daucoides'' is a species of flowering plant in the carrot family known by many common names, including toothpick-plant, toothpickweed, bisnaga, khella, or sometimes bishop's weed. It is native to Europe, Asia, and North Africa, but it ...'' or in '' Pimpinella monoica''. References {{heterocyclic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Visnagin
Visnagin is an organic chemical compound with the molecular formula C13 H10 O4 It is a furanochromone, a compound derivative of chromone (1,4-benzopyrone) and furan. History '' Ammi visnaga'', the main source for visnagin, has been used in traditional medicine in the Middle East to ease urinary tract pain associated with kidney stones and to promote stone passage. Occurrences Visnagin naturally occurs in ''Ammi visnaga'', a species of flowering plant in the carrot family known by many common names, including bisnaga, toothpickweed, and khella. Visnagin-containing khella seeds are usually found mainly in Middle East countries such as Egypt and Turkey and also in Northern African countries such as Morocco. Visnagin can be extracted directly from khella seeds. Synthesis Modified synthesis of the naturally occurring visnagin is reported. Starting from phloroghrcin aldehyde, and building on the 2-methyl-y-pyrone, 2-methyl-5,7-dihydroxy-dfo-yl-chromone was obtained. Construction o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amikhelline
Amikhelline is an antimitotic drug. It acts as a DNA intercalator and inhibits DNA polymerase A DNA polymerase is a member of a family of enzymes that catalyze the synthesis of DNA molecules from nucleoside triphosphates, the molecular precursors of DNA. These enzymes are essential for DNA replication and usually work in groups to create .... References Antineoplastic and immunomodulating drugs Benzofuran ethers at the benzene ring Furanochromones DNA intercalaters DNA polymerase inhibitors Diethylamino compounds {{antineoplastic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ammi (plant)
''Ammi'' is a genus of about six species of summer-flowering plants in the carrot family Apiaceae. They are native to southern Europe, northern Africa and south-western Asia. They have fern-like leaves and white or cream coloured lace-like flowers borne in branched, rounded umbels. ''Ammi spp.'' (Bishops weed) is prohibited by the Australian New Zealand Food Standards code under standard 1.4.4 due to active constituents: * furocromine * coumarin derivatives * .03% volatile oil (camphor and carvone) * Fixed oil and protein * flavonol glycosides (quercetin and kaempferol) ''Ammi majus'', ''A. visnaga'' and their cultivars are frequently seen in gardens where they are grown as annuals or biennials. Species The following species are recognised in the genus ''Ammi'': *'' Ammi huntii'' H.C.Watson *''Ammi majus'' L. *''Ammi trifoliatum ''Ammi trifoliatum'' is a species of flowering plant in the celery family Apiaceae, endemic to the Azores ) , motto =( en, "Rather die free th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angina Pectoris
Angina, also known as angina pectoris, is chest pain or pressure, usually caused by insufficient blood flow to the heart muscle (myocardium). It is most commonly a symptom of coronary artery disease. Angina is typically the result of obstruction or spasm of the arteries that supply blood to the heart muscle. The main mechanism of coronary artery obstruction is atherosclerosis as part of coronary artery disease. Other causes of angina include abnormal heart rhythms, heart failure and, less commonly, anemia. The term derives from the Latin ''angere'' ("to strangle") and ''pectus'' ("chest"), and can therefore be translated as "a strangling feeling in the chest". There is a weak relationship between severity of angina and degree of oxygen deprivation in the heart muscle, however, the severity of angina does not always match the degree of oxygen deprivation to the heart or the risk of a myocardial infarction (heart attack). Some people may experience severe pain even though ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ureter
The ureters are tubes made of smooth muscle that propel urine from the kidneys to the urinary bladder. In a human adult, the ureters are usually long and around in diameter. The ureter is lined by urothelial cells, a type of transitional epithelium, and has an additional smooth muscle layer that assists with peristalsis in its lowest third. The ureters can be affected by a number of diseases, including urinary tract infections and kidney stone. is when a ureter is narrowed, due to for example chronic inflammation. Congenital abnormalities that affect the ureters can include the development of two ureters on the same side or abnormally placed ureters. Additionally, reflux of urine from the bladder back up the ureters is a condition commonly seen in children. The ureters have been identified for at least two thousand years, with the word "ureter" stemming from the stem relating to urinating and seen in written records since at least the time of Hippocrates. It is, however, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diuretic
A diuretic () is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics increase the excretion of water from the body, through the kidneys. There exist several classes of diuretic, and each works in a distinct way. Alternatively, an antidiuretic, such as vasopressin ( antidiuretic hormone), is an agent or drug which reduces the excretion of water in urine. Medical uses In medicine, diuretics are used to treat heart failure, liver cirrhosis, hypertension, influenza, water poisoning, and certain kidney diseases. Some diuretics, such as acetazolamide, help to make the urine more alkaline, and are helpful in increasing excretion of substances such as aspirin in cases of overdose or poisoning. Diuretics are sometimes abused by people with an eating disorder, especially people with bulimia nervosa, with the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calculus (medicine)
A calculus (plural calculi), often called a stone, is a concretion of material, usually mineral salts, that forms in an organ or duct of the body. Formation of calculi is known as lithiasis (). Stones can cause a number of medical conditions. Some common principles (below) apply to stones at any location, but for specifics see the particular stone type in question. Calculi are not to be confused with gastroliths. Types * Calculi in the urinary system are called urinary calculi and include kidney stones (also called renal calculi or nephroliths) and bladder stones (also called vesical calculi or cystoliths). They can have any of several compositions, including mixed. Principal compositions include oxalate and urate. * Calculi of the gallbladder and bile ducts are called gallstones and are primarily developed from bile salts and cholesterol derivatives. * Calculi in the nasal passages (rhinoliths) are rare. * Calculi in the gastrointestinal tract (enteroliths) can be enorm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
