Kaurenoic Acid

	Kaurenoic Acid Kaurenoic acid (ent-kaur-16-en-19-oic acid or Kauren-19-oic acid) is a diterpene with antibacterial activity against Gram-positive bacteria. However its low solubility and blood lytic activity on erythrocytes might make it a poor pharmaceutical candidate. Kaurenoic acid also has uterine relaxant activity via calcium blockade and opening ATP-sensitive potassium channels. Kaurenoic acid is found in several plants such as Copaifera. It is a potential biomarker for the presence of sunflower in foods. Medical use Kaurenoic acid has been studied for its medicinal properties and seems to have anti-inflammatory, antiulcerogenic, antitumor, antinociceptive, antimelanoma, antitilipoperoxidation, antioxidant and antimicrobial properties. Kaurenoic acid decreases leukocyte migration. It seems to inhibit histamine and serotonin pathways, in addition to antiprotozoal activities against '' Trypanosoma cruzi'' and ''Leishmania amazonensis ''Leishmania amazonensis'' is a parasite responsibl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Diterpene Diterpenes are a class of chemical compounds composed of four isoprene units, often with the molecular formula C20H32. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being a primary intermediate. Diterpenes form the basis for biologically important compounds such as retinol, retinal, and phytol. They are known to be antimicrobial and antiinflammatory. Structures As with most terpenes a huge number of potential structures exists, which may be broadly divided according to the number of rings present. Biosynthesis Diterpenes are derived from the addition of one IPP unit to FPP to form geranylgeranyl-pyrophosphate (GGPP). From GGPP, structural diversity is achieved mainly by two classes of enzymes; the diterpene synthases and cytochromes P450. Several diterpenes are produced by plants and cyanobacteria. GGPP is also the precursor for the synthesis of the phytane by the action of the enzyme geranylger ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Gram-positive Bacteria In bacteriology, gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their type of cell wall. Gram-positive bacteria take up the crystal violet stain used in the test, and then appear to be purple-coloured when seen through an optical microscope. This is because the thick peptidoglycan layer in the bacterial cell wall retains the stain after it is washed away from the rest of the sample, in the decolorization stage of the test. Conversely, gram-negative bacteria cannot retain the violet stain after the decolorization step; alcohol used in this stage degrades the outer membrane of gram-negative cells, making the cell wall more porous and incapable of retaining the crystal violet stain. Their peptidoglycan layer is much thinner and sandwiched between an inner cell membrane and a bacterial outer membrane, causing them to take up the counterstain (sa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Copaifera ''Copaifera'' is a genus of tropical plants in the legume family Fabaceae. The scientific name means "copal-bearer" (or more accurately, ''copaiba''-bearer), since economically important resins and essential oils can be acquired from them. They are also important for production of biodiesel and wood, especially ''Copaifera langsdorffii''. Other species are threatened, mainly by deforestation. Oil extracts from the genus are of particular interest as a source of antimycobacterial agents. Notable species ''Copaifera epunctata'' '' Copaifera guyanensis'' ''Copaifera langsdorffii'' – Diesel tree, kerosene tree, kupa'y, cabismo, copaúva ''Copaifera martii'' ''Copaifera multijuga'' ''Copaifera officinalis'' ''Copaifera panamensis'' – Cabimo ''Copaifera reticulata'' ''Copaifera salikounda'' ''Copaifera trapezifolia'' ''Copaifera cearensis'' ''Copaifera jacquinii'' ''Copaifera coriacea'' See also Copaene Copaene, or more precisely, α-copaene, is the common (or tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Trypanosoma Cruzi ''Trypanosoma cruzi'' is a species of parasitic euglenoids. Among the protozoa, the trypanosomes characteristically bore tissue in another organism and feed on blood (primarily) and also lymph. This behaviour causes disease or the likelihood of disease that varies with the organism: Chagas disease in humans, dourine and surra in horses, and a brucellosis-like disease in cattle. Parasites need a host body and the haematophagous insect triatomine (descriptions "assassin bug", "cone-nose bug", and "kissing bug") is the major vector in accord with a mechanism of infection. The triatomine likes the nests of vertebrate animals for shelter, where it bites and sucks blood for food. Individual triatomines infected with protozoa from other contact with animals transmit trypanosomes when the triatomine deposits its faeces on the host's skin surface and then bites. Penetration of the infected faeces is further facilitated by the scratching of the bite area by the human or animal host. Life ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Leishmania Amazonensis ''Leishmania amazonensis'' is a parasite responsible for the disease leishmaniasis. This species has been known to spread by using sandflies Sandfly (or sand fly) is a colloquial name for any species or genus of flying, biting, blood-sucking dipteran (fly) encountered in sandy areas. In the United States, ''sandfly'' may refer to certain horse flies that are also known as "greenhe ... as its vector and a vertebrate as its primary host, just like other species of Leishmania. They have also been known to spread throughout the Brazilian Amazon region due to their ecological niches needed for survival and reproduction. However, when the host is infected, the Leishmania can cause 3 different forms of Leishmaniasis. For this species, it has been known to cause cutaneous leishmaniasis and mucocutaneous leishmaniasis. Cutaneous leishmaniasis is commonly characterized with skin lesions, which can appear localized, or throughout the body. While mucocutaneous leishmaniasis is charact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Diterpenes Diterpenes are a class of chemical compounds composed of four isoprene units, often with the molecular formula C20H32. They are biosynthesized by plants, animals and fungi via the HMG-CoA reductase pathway, with geranylgeranyl pyrophosphate being a primary intermediate. Diterpenes form the basis for biologically important compounds such as retinol, retinal, and phytol. They are known to be antimicrobial and antiinflammatory. Structures As with most terpenes a huge number of potential structures exists, which may be broadly divided according to the number of rings present. Biosynthesis Diterpenes are derived from the addition of one IPP unit to FPP to form geranylgeranyl-pyrophosphate (GGPP). From GGPP, structural diversity is achieved mainly by two classes of enzymes; the diterpene synthases and cytochromes P450. Several diterpenes are produced by plants and cyanobacteria. GGPP is also the precursor for the synthesis of the phytane by the action of the enzyme geranylger ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Tetracyclic Compounds Tetracyclics are cyclic chemical compounds that contain four interconnected rings of atoms, e.g. Tröger's base. They have various pharmaceutical uses, for instance the tetracycline antibiotics and the tetracyclic antidepressants. See also * Tricyclic * Heterocyclic A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of its ring(s). Heterocyclic chemistry is the branch of organic chemistry dealing with the synthesis, properties, and ... References {{Reflist Tetracyclic compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]