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Housekeeping Genes
In molecular biology, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. Although some housekeeping genes are expressed at relatively constant rates in most non-pathological situations, the expression of other housekeeping genes may vary depending on experimental conditions. The origin of the term "housekeeping gene" remains obscure. Literature from 1976 used the term to describe specifically tRNA and rRNA. For experimental purposes, the expression of one or multiple housekeeping genes is used as a reference point for the analysis of expression levels of other genes. The key criterion for the use of a housekeeping gene in this manner is that the chosen housekeeping gene is uniformly expressed with low variance under both control and experimental conditions. Validation of housekeeping genes should be performed before th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ATF7
Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ''ATF7'' gene. Homonym In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1. This ATF-7 is actually ATF5 Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ''ATF5'' gene. Function First described by Nishizawa and Nagata, ATF5 has been classified as a member of the activating transcription factor ... and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.") R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BAT1
Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the ''BAT1'' gene. This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be in ... encodi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein SNRPB PDB 1d3b
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residues in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PUF60
Poly(U)-binding-splicing factor PUF60 is a protein that in humans is encoded by the ''PUF60'' gene. The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene. Interactions PUF60 has been shown to interact with U2AF2 Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the ''U2AF2'' gene. Function In eukaryotes, the introns in the transcribed pre-mRNA first have to be removed by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TCEB2
Elongin B is a protein that in humans is encoded by the ''ELOB'' gene. Function Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Interactions TCEB2 has been shown to interact with: * CUL2, * TCEB1, and * Von Hippel-Lindau tumor suppressor The term ''von'' () is used in German language surna ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
JUND
Under the early Caliphates, a ''jund'' ( ar, جند; plural ''ajnad'', اجناد) was a military division, which became applied to Arab military colonies in the conquered lands and, most notably, to the provinces into which Greater Syria (the Levant) was divided. ''Jund'' later acquired various meanings throughout the Muslim world. Origin The term ''jund'' derives from Parthian or Iranian word of "Gund" which was later on adopted by Islamic armies after the conquest of Iran. Today, "Gund" still refers to "town, village" as well as gathering (military) in Kurdish which was passed to Arabic with similar meaning of a group of supporters (also could refer to a group in general like in a city) ''Lisan al-Arab'' , and appears in the ''Quran'' to designate an armed troop. Under the Umayyad Caliphate it came to be applied in a more technical sense to "military settlements and districts in which were quartered Arab soldiers who could be mobilized for seasonal campaigns or for more pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IER2
The Ier or Eriu ( hu, Ér) is a right tributary of the river Barcău (''Berettyó'') in Romania and Hungary. It discharges into the Barcău in Pocsaj. The Andrid Dam is constructed on this river. The Ier flows through the villages Mihăieni, Eriu-Sâncrai, Ghirolt, Rădulești, Hotoan, Sudurău, Dindești, Andrid, Sălacea, Cherechiu, Săcueni, Diosig in Romania, and Pocsaj in Hungary. In Romania, its length is and its basin size is . Hydronymy The Hungarian name of the river means "brook". The Romanian name derives from that. Tributaries The following rivers are tributaries to the river Ier: *Left: Checheț, Santău, Sărvăzel, Pir *Right: Cubic, Sânmiclăuș, Pârâul Morii, Zimoiaș, Rât, Salcia, Ierul Îngust The Ierul Îngust is a right tributary of the river Ier in Romania. It flows into the Ier near Diosig, close to the Hungary, Hungarian border. Its length is and its basin size is . References Rivers of Romania Rivers of Bihor County { ... ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ILF2
Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ''ILF2'' gene. Function Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression. Interactions ILF2 has been shown to interact with CDC5L and DNA-PKcs DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene designated as ''PRKDC'' or ''XRCC7''. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related k ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HMGB1
High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the ''HMGB1'' gene. HMG-1 belongs to the high mobility group and contains a HMG-box domain. Function Like the histones, HMGB1 is among the most important chromatin proteins. In the nucleus HMGB1 interacts with nucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and regulates transcription. After binding, HMGB1 bends DNA, which facilitates the binding of other proteins. HMGB1 supports transcription of many genes in interactions with many transcription factors. It also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. Contact with core histones changes the structure of nucleosomes. The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ERH (gene)
In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ''ERH'' gene. The ''Drosophila'' protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis. From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms. It has been proposed that this protein plays a role in the cell cycle The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and sub .... References Further reading * * * * * * * * External links PDBe-KBprovides an overview of all the structure information available in the PDB for Human Enhancer of rudimentary homolog (ERH ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
