High-performance Computer
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High-performance Computer
A supercomputer is a computer with a high level of performance as compared to a general-purpose computer. The performance of a supercomputer is commonly measured in floating-point operations per second (FLOPS) instead of million instructions per second (MIPS). Since 2017, there have existed supercomputers which can perform over 1017 FLOPS (a hundred Orders of magnitude (numbers)#1015, quadrillion FLOPS, 100 petaFLOPS or 100 PFLOPS). For comparison, a desktop computer has performance in the range of hundreds of gigaFLOPS (1011) to tens of teraFLOPS (1013). Since November 2017, all of the TOP500, world's fastest 500 supercomputers run on Linux-based operating systems. Additional research is being conducted in the United States, the European Union, Taiwan, Japan, and China to build faster, more powerful and technologically superior Exascale computing, exascale supercomputers. Supercomputers play an important role in the field of computational science, and are used ...
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Macromolecules
A macromolecule is a very large molecule important to biophysical processes, such as a protein or nucleic acid. It is composed of thousands of covalently bonded atoms. Many macromolecules are polymers of smaller molecules called monomers. The most common macromolecules in biochemistry are biopolymers (nucleic acids, proteins, and carbohydrates) and large non-polymeric molecules such as lipids, nanogels and macrocycles. Synthetic fibers and experimental materials such as carbon nanotubes are also examples of macromolecules. Definition The term ''macromolecule'' (''macro-'' + ''molecule'') was coined by Nobel laureate Hermann Staudinger in the 1920s, although his first relevant publication on this field only mentions ''high molecular compounds'' (in excess of 1,000 atoms). At that time the term ''polymer'', as introduced by Berzelius in 1832, had a different meaning from that of today: it simply was another form of isomerism for example with benzene and acetylene and had little ...
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Frontier (supercomputer)
Hewlett Packard Enterprise Frontier, or OLCF-5, is the world's first exascale supercomputer, hosted at the Oak Ridge Leadership Computing Facility (OLCF) in Tennessee, United States and first operational in 2022. It is based on the Cray EX and is the successor to Summit (OLCF-4). , Frontier was the world's fastest supercomputer using AMD CPUs and GPUs. Frontier achieved an Rmax of 1.102 exaFLOPS, which is 1.102 quintillion operations per second. Measured at 62.68 gigaflops/watt, Frontier topped the Green500 list for most efficient supercomputer, until it was dethroned by Flatiron Institute's Henri supercomputer in November 2022. Design Frontier uses 9,472 AMD Epyc 7A53s "Trento" 64 core 2 GHz CPUs (606,208 cores) and 37,888 Radeon Instinct MI250X GPUs (8,335,360 cores). They can perform double precision operations at the same speed as single precision. "Trento" is an optimized 3rd Gen EPYC CPU ("Milan"), which itself is based on Zen 3. It occupies 74 rack cabinets. E ...
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Massively Parallel (computing)
Massively parallel is the term for using a large number of computer processors (or separate computers) to simultaneously perform a set of coordinated computations in parallel. GPUs are massively parallel architecture with tens of thousands of threads. One approach is grid computing, where the processing power of many computers in distributed, diverse administrative domains is opportunistically used whenever a computer is available.''Grid computing: experiment management, tool integration, and scientific workflows'' by Radu Prodan, Thomas Fahringer 2007 pages 1–4 An example is BOINC, a volunteer-based, opportunistic grid system, whereby the grid provides power only on a best effort basis.''Parallel and Distributed Computational Intelligence'' by Francisco Fernández de Vega 2010 pages 65–68 Another approach is grouping many processors in close proximity to each other, as in a computer cluster. In such a centralized system the speed and flexibility of the interconnect beco ...
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Cray-1
The Cray-1 was a supercomputer designed, manufactured and marketed by Cray Research. Announced in 1975, the first Cray-1 system was installed at Los Alamos National Laboratory in 1976. Eventually, over 100 Cray-1s were sold, making it one of the most successful supercomputers in history. It is perhaps best known for its unique shape, a relatively small C-shaped cabinet with a ring of benches around the outside covering the power supplies and the cooling system. The Cray-1 was the first supercomputer to successfully implement the vector processor design. These systems improve the performance of math operations by arranging memory and registers to quickly perform a single operation on a large set of data. Previous systems like the CDC STAR-100 and ASC had implemented these concepts but did so in a way that seriously limited their performance. The Cray-1 addressed these problems and produced a machine that ran several times faster than any similar design. The Cray-1's architect w ...
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Vector Processor
In computing, a vector processor or array processor is a central processing unit (CPU) that implements an instruction set where its instructions are designed to operate efficiently and effectively on large one-dimensional arrays of data called ''vectors''. This is in contrast to scalar processors, whose instructions operate on single data items only, and in contrast to some of those same scalar processors having additional single instruction, multiple data (SIMD) or SWAR Arithmetic Units. Vector processors can greatly improve performance on certain workloads, notably numerical simulation and similar tasks. Vector processing techniques also operate in video-game console hardware and in graphics accelerators. Vector machines appeared in the early 1970s and dominated supercomputer design through the 1970s into the 1990s, notably the various Cray platforms. The rapid fall in the price-to-performance ratio of conventional microprocessor designs led to a decline in vector supercom ...
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Central Processing Unit
A central processing unit (CPU), also called a central processor, main processor or just processor, is the electronic circuitry that executes instructions comprising a computer program. The CPU performs basic arithmetic, logic, controlling, and input/output (I/O) operations specified by the instructions in the program. This contrasts with external components such as main memory and I/O circuitry, and specialized processors such as graphics processing units (GPUs). The form, design, and implementation of CPUs have changed over time, but their fundamental operation remains almost unchanged. Principal components of a CPU include the arithmetic–logic unit (ALU) that performs arithmetic and logic operations, processor registers that supply operands to the ALU and store the results of ALU operations, and a control unit that orchestrates the fetching (from memory), decoding and execution (of instructions) by directing the coordinated operations of the ALU, registers and other co ...
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Parallel Computing
Parallel computing is a type of computation in which many calculations or processes are carried out simultaneously. Large problems can often be divided into smaller ones, which can then be solved at the same time. There are several different forms of parallel computing: bit-level, instruction-level, data, and task parallelism. Parallelism has long been employed in high-performance computing, but has gained broader interest due to the physical constraints preventing frequency scaling.S.V. Adve ''et al.'' (November 2008)"Parallel Computing Research at Illinois: The UPCRC Agenda" (PDF). Parallel@Illinois, University of Illinois at Urbana-Champaign. "The main techniques for these performance benefits—increased clock frequency and smarter but increasingly complex architectures—are now hitting the so-called power wall. The computer industry has accepted that future performance increases must largely come from increasing the number of processors (or cores) on a die, rather than m ...
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Cray Research
Cray Inc., a subsidiary of Hewlett Packard Enterprise, is an American supercomputer manufacturer headquartered in Seattle, Washington. It also manufactures systems for data storage and analytics. Several Cray supercomputer systems are listed in the TOP500, which ranks the most powerful supercomputers in the world. Cray manufactures its products in part in Chippewa Falls, Wisconsin, where its founder, Seymour Cray, was born and raised. The company also has offices in Bloomington, Minnesota (which have been converted to Hewlett Packard Enterprise offices), and numerous other sales, service, engineering, and R&D locations around the world. The company's predecessor, Cray Research, Inc. (CRI), was founded in 1972 by computer designer Seymour Cray. Seymour Cray later formed Cray Computer Corporation (CCC) in 1989, which went bankrupt in 1995. Cray Research was acquired by Silicon Graphics (SGI) in 1996. Cray Inc. was formed in 2000 when Tera Computer Company purchased the Cray Res ...
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Control Data Corporation
Control Data Corporation (CDC) was a mainframe and supercomputer firm. CDC was one of the nine major United States computer companies through most of the 1960s; the others were IBM, Burroughs Corporation, DEC, NCR, General Electric, Honeywell, RCA, and UNIVAC. CDC was well-known and highly regarded throughout the industry at the time. For most of the 1960s, Seymour Cray worked at CDC and developed a series of machines that were the fastest computers in the world by far, until Cray left the company to found Cray Research (CRI) in the 1970s. After several years of losses in the early 1980s, in 1988 CDC started to leave the computer manufacturing business and sell the related parts of the company, a process that was completed in 1992 with the creation of Control Data Systems, Inc. The remaining businesses of CDC currently operate as Ceridian. Background and origins: World War II–1957 During World War II the U.S. Navy had built up a classified team of engineers to build codeb ...
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Seymour Cray
Seymour Roger Cray (September 28, 1925 – October 5, 1996
) was an American and architect who designed a series of computers that were the fastest in the world for decades, and founded which built many of these machines. Called "the father of supercomputing", Cray has been credited with creating the supercomputer industry.

Cryptanalysis
Cryptanalysis (from the Greek ''kryptós'', "hidden", and ''analýein'', "to analyze") refers to the process of analyzing information systems in order to understand hidden aspects of the systems. Cryptanalysis is used to breach cryptographic security systems and gain access to the contents of encrypted messages, even if the cryptographic key is unknown. In addition to mathematical analysis of cryptographic algorithms, cryptanalysis includes the study of side-channel attacks that do not target weaknesses in the cryptographic algorithms themselves, but instead exploit weaknesses in their implementation. Even though the goal has been the same, the methods and techniques of cryptanalysis have changed drastically through the history of cryptography, adapting to increasing cryptographic complexity, ranging from the pen-and-paper methods of the past, through machines like the British Bombes and Colossus computers at Bletchley Park in World War II, to the mathematically advanced comput ...
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