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Human Genome Project
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It remains the world's largest collaborative biological project. Planning started after the idea was picked up in 1984 by the US government, the project formally launched in 1990, and was declared essentially complete on April 14, 2003, but included only about 85% of the genome. Level "complete genome" was achieved in May 2021, with a remaining only 0.3% bases covered by potential issues. The final gapless assembly was finished in January 2022. Funding came from the United States government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside the government by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles DeLisi
Charles Peter DeLisi (born December 9, 1941) is an American biomedical scientist and the Metcalf Professor of Science and Engineering at Boston University. He is noted for major contributions to the initiation of the Human Genome Project, for transformative academic leadership, and for research contributions to mathematical and computational immunology, cell biophysics, genomicsYanai, I., Derti, A., and DeLisi, C. Genes linked by fusion events are generally of the same functional category: A systematic analysis of 30 microbial genomes. PNAS, v 98, 7940-7945, 2001 and protein and nucleic acid structure and function. Recent activities include mathematical finance and climate change. Early life and education DeLisi was born in the Bronx, graduated from City College of New York (CCNY) with a Bachelor of Arts degree in history (1963), and received his Ph.D. in physics (1965 -1969) from New York University (NYU). Career and research In 1969 he joined Donald Crothers’ laboratory a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Logo HGP
A logo (abbreviation of logotype; ) is a graphic mark, emblem, or symbol used to aid and promote public identification and recognition. It may be of an abstract or figurative design or include the text of the name it represents as in a wordmark. In the days of hot metal typesetting, a logotype was one word cast as a single piece of type (e.g. "The" in ATF Garamond), as opposed to a ligature, which is two or more letters joined, but not forming a word. By extension, the term was also used for a uniquely set and arranged typeface or colophon. At the level of mass communication and in common usage, a company's logo is today often synonymous with its trademark or brand.Wheeler, Alina. ''Designing Brand Identity'' © 2006 John Wiley & Sons, Inc. (page 4) Etymology Douglas Harper's Online Etymology Dictionary states that the term 'logo' used in 1937 "probably a shortening of logogram". History Numerous inventions and techniques have contributed to the contemporary logo, in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
China
China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and borders fourteen countries by land, the most of any country in the world, tied with Russia. Covering an area of approximately , it is the world's third largest country by total land area. The country consists of 22 provinces, five autonomous regions, four municipalities, and two Special Administrative Regions (Hong Kong and Macau). The national capital is Beijing, and the most populous city and financial center is Shanghai. Modern Chinese trace their origins to a cradle of civilization in the fertile basin of the Yellow River in the North China Plain. The semi-legendary Xia dynasty in the 21st century BCE and the well-attested Shang and Zhou dynasties developed a bureaucratic political system to serve hereditary monarchies, or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Watson
James Dewey Watson (born April 6, 1928) is an American molecular biologist, geneticist, and zoologist. In 1953, he co-authored with Francis Crick the academic paper proposing the double helix structure of the DNA molecule. Watson, Crick and Maurice Wilkins were awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". In subsequent years, it has been recognized that Watson and his colleagues did not properly attribute colleague Rosalind Franklin for her contributions to the discovery of the double helix structure. Watson earned degrees at the University of Chicago ( BS, 1947) and Indiana University (PhD, 1950). Following a post-doctoral year at the University of Copenhagen with Herman Kalckar and Ole Maaløe, Watson worked at the University of Cambridge's Cavendish Laboratory in England, where he first met his future collaborator ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature'' cover the full r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Whole Genome Sequencing
Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014. In the future of personalized medicine, whole genome sequence data may be an important tool to guide therapeutic intervention. The tool of gene sequencing at SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response. Whole genome sequencing should not be confused with DNA profiling ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salk Institute For Biological Studies
The Salk Institute for Biological Studies is a scientific research institute located in the La Jolla community of San Diego, California, U.S. The independent, non-profit institute was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Construction of the research facilities began in spring of 1962. The Salk Institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences. In 2004, the '' Times Higher Education Supplement'' ranked Salk as the world's top biomedicine research institute, and in 2009 it was ranked number one globally by '' ScienceWatch'' in the neuroscience and behavior areas. The Salk Institute employs 850 researchers in 60 research groups and focuses its research in three areas: molecular biology and genetics; neurosciences; and plant biology. Research topics include aging, cancer, diabetes, birth defects, Alzheimer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renato Dulbecco
Renato Dulbecco ( , ; February 22, 1914 – February 19, 2012) was an Italian–American virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect animal cells. He studied at the University of Turin under Giuseppe Levi, along with fellow students Salvador Luria and Rita Levi-Montalcini, who also moved to the U.S. with him and won Nobel prizes. He was drafted into the Italian army in World War II, but later joined the resistance. Early life Dulbecco was born in Catanzaro (Southern Italy), but spent his childhood and grew up in Liguria, in the coastal city Imperia. He graduated from high school at 16, then moved to the University of Turin. Despite a strong interest in mathematics and physics, he decided to study medicine. At only 22, he graduated in morbid anatomy and pathology under the supervision of professor Giuseppe Levi. During these years he met Salvador Luria and Rita Levi-M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Department Of Energy
The United States Department of Energy (DOE) is an executive department of the U.S. federal government that oversees U.S. national energy policy and manages the research and development of nuclear power and nuclear weapons in the United States. The DOE oversees the U.S. nuclear weapons program, nuclear reactor production for the United States Navy, energy-related research, and domestic energy production and energy conservation. The DOE was created in 1977 in the aftermath of the 1973 oil crisis. It sponsors more physical science research than any other U.S. federal agency, the majority of which is conducted through its system of National Laboratories. The DOE also directs research in genomics, with the Human Genome Project originating from a DOE initiative. The department is headed by the Secretary of Energy, who reports directly to the president of the United States and is a member of the Cabinet. The current Secretary of Energy is Jennifer Granholm, who has served ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Santa Cruz
The University of California, Santa Cruz (UC Santa Cruz or UCSC) is a public land-grant research university in Santa Cruz, California. It is one of the ten campuses in the University of California system. Located on Monterey Bay, on the edge of the coastal community of Santa Cruz, the campus lies on of rolling, forested hills overlooking the Pacific Ocean. Founded in 1965, UC Santa Cruz began with the intention to showcase progressive, cross-disciplinary undergraduate education, innovative teaching methods and contemporary architecture. The residential college system consists of ten small colleges that were established as a variation of the Oxbridge collegiate university system. Among the Faculty is 1 Nobel Prize Laureate, 1 Breakthrough Prize in Life Sciences recipient, 12 members from the National Academy of Sciences, 28 members of the American Academy of Arts and Sciences, and 40 members of the American Association for the Advancement of Science. Eight UC Santa Cruz alumn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Euchromatic
Euchromatin (also called "open chromatin") is a lightly packed form of chromatin (DNA, RNA, and protein) that is enriched in genes, and is often (but not always) under active Transcription (genetics), transcription. Euchromatin stands in contrast to heterochromatin, which is tightly packed and less accessible for transcription. 92% of the human genome is euchromatic. In eukaryotes, euchromatin comprises the most active portion of the genome within the cell nucleus. In prokaryotes, euchromatin is the ''only'' form of chromatin present; this indicates that the heterochromatin structure evolved later along with the Cell nucleus, nucleus, possibly as a mechanism to handle increasing genome size. Structure Euchromatin is composed of repeating subunits known as nucleosomes, reminiscent of an unfolded set of beads on a string, that are approximately 11 nm in diameter. At the core of these nucleosomes are a set of four histone protein pairs: Histone H3, H3, Histone H4, H4, Histone ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
