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Honokiol
Honokiol is a lignan isolated from the bark, seed cones, and leaves of trees belonging to the genus ''Magnolia''. It has been identified as one of the chemical compounds in some traditional eastern herbal medicines along with magnolol, 4-O-methylhonokiol, and obovatol. Biology Honokiol has been extracted from a number of species of ''Magnolia'' native to many regions of the globe. ''Magnolia grandiflora'', which is native to the American South, as well as Mexican species like '' Magnolia dealbata'' have been found to be sources of honokiol. Traditionally in Asian medicine, the ''Magnolia biondii'', ''Magnolia obovata'', and ''Magnolia officinalis'' are commonly used. The compound itself has a spicy odor. Because of its physical properties, honokiol can readily cross the blood brain barrier and the blood-cerebrospinal fluid barrier. As a result, honokiol is a potentially potent therapy with high bioavailability. Chemistry Structure Honokiol belongs to a class of neolignan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnolia
''Magnolia'' is a large genus of about 210 to 340The number of species in the genus ''Magnolia'' depends on the taxonomic view that one takes up. Recent molecular and morphological research shows that former genera ''Talauma'', ''Dugandiodendron'', ''Manglietia'', ''Michelia'', ''Elmerrillia'', ''Kmeria'', ''Parakmeria'', ''Pachylarnax'' (and a small number of monospecific genera) all belong within the same genus, ''Magnolia'' s.l. (s.l. = ''sensu lato'': 'in a broad sense', as opposed to s.s. = ''sensu stricto'': 'in a narrow sense'). The genus ''Magnolia'' s.s. contains about 120 species. See the section Nomenclature and classification in this article. flowering plant species in the subfamily Magnolioideae of the family Magnoliaceae. It is named after French botanist Pierre Magnol. ''Magnolia'' is an ancient genus. Appearing before bees evolved, the flowers are theorized to have evolved to encourage pollination by beetles. To avoid damage from pollinating beetles, the carpe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnolol
Magnolol is an organic compound that is classified as lignan. It is a bioactive compound found in the bark of the Houpu magnolia (''Magnolia officinalis'') or in '' M. grandiflora''. The compound exists at the level of a few percent in the bark of species of magnolia, the extracts of which have been used in traditional Chinese and Japanese medicine. In addition to magnolol, related lignans occur in the extracts including honokiol, which is an isomer of magnolol. Bioactivity It is known to act on the GABAA receptors in rat cells in vitro as well as having antifungal properties. Magnolol has a number of osteoblast-stimulating and osteoclast-inhibiting activities in cell culture and has been suggested as a candidate for screening for anti-osteoporosis activity. It has anti-periodontal disease activity in a rat model. Structural analogues have been studied and found to be strong allosteric modulators of GABAA. Magnolol is also binding in dimeric mode to PPARγ Peroxisome prol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bark Isolate
Bark isolates are chemicals which have been extracted from bark. Prominent medical examples are salicylic acid (active metabolite of aspirin) and paclitaxel (Taxol). The pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ... of bark isolates is an ongoing topic of medical research. See also Notes {{Reflist Trees Pharmaceutical isolates ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetone
Acetone (2-propanone or dimethyl ketone), is an organic compound with the formula . It is the simplest and smallest ketone (). It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscible with water and serves as an important organic solvent in its own right, in industry, home, and laboratory. About 6.7 million tonnes were produced worldwide in 2010, mainly for use as a solvent and production of methyl methacrylate (and from that PMMA) as well as bisphenol A.Acetone World Petrochemicals report, January 2010Stylianos Sifniades, Alan B. Levy, "Acetone" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005. It is a common building block in |
Lignan
The lignans are a large group of low molecular weight polyphenols found in plants, particularly seeds, whole grains, and vegetables. The name derives from the Latin word for "wood". Lignans are precursors to phytoestrogens. They may play a role as antifeedants in the defense of seeds and plants against herbivores. Biosynthesis and metabolism Lignans and lignin differ in their molecular weight, the former being small and soluble in water, the latter being high polymers that are undigestable. Both are polyphenolic substances derived by oxidative coupling of monolignols. Thus, most lignans feature a C18 cores, resulting from the dimerization of C9 precursors. The coupling of the lignols occurs at C8. Eight classes of lignans are: "furofuran, furan, dibenzylbutane, dibenzylbutyrolactone, aryltetralin, arylnaphthalene, dibenzocyclooctadiene, and dibenzylbutyrolactol." Many lignans are metabolized by mammalian gut microflora, producing so-called enterolignans. Food sources Flax s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrogen Bonding
In chemistry, a hydrogen bond (or H-bond) is a primarily electrostatic force of attraction between a hydrogen (H) atom which is covalently bound to a more electronegative "donor" atom or group (Dn), and another electronegative atom bearing a lone pair of electrons—the hydrogen bond acceptor (Ac). Such an interacting system is generally denoted , where the solid line denotes a polar covalent bond, and the dotted or dashed line indicates the hydrogen bond. The most frequent donor and acceptor atoms are the second-row elements nitrogen (N), oxygen (O), and fluorine (F). Hydrogen bonds can be intermolecular (occurring between separate molecules) or intramolecular (occurring among parts of the same molecule). The energy of a hydrogen bond depends on the geometry, the environment, and the nature of the specific donor and acceptor atoms and can vary between 1 and 40 kcal/mol. This makes them somewhat stronger than a van der Waals interaction, and weaker than fully covalent or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioavailability
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation. By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via routes other than intravenous, its bioavailability is generally lower than that of intravenous due to intestinal endothelium absorption and first-pass metabolism. Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. AUC is used because AUC is proportional to the dose that has entered the systemic circulation. Bioavailability of a drug is an average value; to take population variability into account, deviation range is shown as ±. To ensure that the drug taker who has poor absorption is dosed appropriately, the bottom value o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Brain Barrier
Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the Cell (biology), cells, and transports Metabolic waste, metabolic waste products away from those same cells. Blood in the circulatory system is also known as ''peripheral blood'', and the blood cells it carries, ''peripheral blood cells''. Blood is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloidal osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). The most abund ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnolia Officinalis
''Magnolia officinalis'' (commonly called houpu magnolia or magnolia-bark) is a species of ''Magnolia'' native to the mountains and valleys of China at altitudes of 300–1500 m. Identification It is a deciduous tree growing to 20 m in height. The Bark (botany), bark is thick and brown, but does not fissure. The Leaf, leaves are broad, ovate, 20–40 cm long, and 11–20 cm broad. The flowers are fragrant and 10–15 cm wide, with 9–12 (rarely to 17) white tepals, and appear from May to June. The two variety (biology), varieties are: *''Magnolia officinalis'' var. ''officinalis'' has leaves with an acute apex. *''Magnolia officinalis'' var. ''biloba'' has leaves with a notch at the apex. This variety does not appear in the wild, and is only known in cultivation. It is possibly not a true variety at all, but actually a cultigen instead, though this has yet to be determined. ''M. officinalis'' differs very little from ''Magnolia obovata''; the only difference c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnolia Obovata
''Magnolia obovata'', the Japanese cucumber tree,Kayano, S. (2014). ''Ainu Tools''. Biratori: Yuideku Co., Ltd. Japanese bigleaf magnolia, or Japanese whitebark magnolia, is a species of ''Magnolia'', native to Japan and the adjacent Kurile Islands. It grows at altitudes near sea level up to 1,800 m in mixed broadleaf forests. Description It is a medium-sized deciduous tree 15–30 m tall, with slate grey bark. The leaves are large, 16–38 cm (rarely to 50 cm) long and 9–20 cm (rarely 25 cm) broad, leathery, green above, silvery or greyish pubescent below, and with an acute apex. They are held in whorls of five to eight at the end of each shoot. The flowers are also large, cup-shaped, 15–20 cm diameter, with 9-12 creamy, fleshy tepals, red stamens; they have a strong scent, and are produced in early summer after the leaves expand. The fruit is an oblong-cylindric aggregate of follicles 12–20 cm long and 6 cm broad, bright pinkish red, e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnolia Biondii
''Magnolia biondii'', or Biondi's magnolia, is a deciduous tree that flowers in late winter to early spring before leaf growth. Its early flowering nature gives it the name of the ''Hope for Spring Flower''. ''Magnolia biondii''is a member of the family Magnoliaceae, which consists of more than 210 species. It is widely found in Northern China. It produces small white flowers every few years. Leave buds and petals of the plant are used to alleviate nasal obstruction and coughing in some parts of China. Distribution ''Magnolia biondii'' is widely distributed in China. It is commonly found in Gansu, Henan, Hubei, Shaanxi, Sichuan provinces. It is usually found in forests in the mountains. The plant was discovered and introduced to the Western hemisphere more than 70 years ago. Habitat and ecology ''Magnolia biondii'' is a deciduous tree that grows mainly in temperate forests in the mountains. It has a broadly conical to spreading habit. Morphology of leaf ''Magnolia biondii'' can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnolia Dealbata
''Magnolia dealbata'' is a species of flowering plant in the family Magnoliaceae, native to Mexico. It is known commonly as the cloudforest magnolia and ''eloxochitl''. It is sometimes considered to be a subspecies of '' Magnolia macrophylla,'' which is otherwise native to the southeastern United States. Description ''Magnolia dealbata'' is a deciduous tree, growing to average heights of 25 meters tall. Larger individuals can reach 40 to 50 meters in height. The flowers are large and white up to 20 cm long. Leaves are broad, reaching 50 cm in length. Distribution and habitat This species is endemic to cloud forests in the Sierra Madre de Oaxaca of northern Oaxaca in eastern Mexico, where it ranges from 600 and 1,900 meters elevation. More than ten subpopulations have been observed, and the species' estimated extent of occurrence is 2,750 to 3,000 km2. The largest population includes over a thousand trees. It grows in humid montane cloud forests, alongside '' Magnolia oaxacensi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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